Trichophyton Rubrum Infections: A Clinical, Mycologic and Experimental Study*

MELANOID PIGMENT PRODUCTION IN A STRAIN OF TRICHOPHYTON RUBRUM

“…Data obtained in this study have confirmed the findings of Lewis and Hopper (1941) and of Silva et al (1955) that glucose or other suitable carbohydrates, such as sorbose, in low concentrations (Zussman, 1959), must be added to a culture medium for the formation of pigment by T. rubrum. However, the specific role of carbohydrate metabolism in pigment formation is unknown.…”

“…Pigment production. The pigment was obtained from T. rubrum grown in shake cultures as described by Silva, Kesten, and Benham (1955), and Jensen, Altschuller, and Bard (1957). The growth medium (Nickerson and Chadwick, 1946) was dispensed into 250-ml Erlenmeyer flasks in volumes of 135 ml and each flask was then inoculated with 1 ml of fungal homogenate (Vicher, Lyon, and White, 1959).…”

Immunology of Surface Fungi Dermatophytes

“…In general, the anthropophilic species tested were relatively nonpathogenic for animals. Silva et al (1955) were able to produce lesions in guinea pigs with some strains of T. rubrum; the infections were short lived.…”

“…Desai et al (1963) could not demonstrate acquired immunity to experimental infections of the smooth skin by T. rubrum. Silva et al (1955) infected patients who already had lesions due to T. rubrum at sites not previously infected. The first experimental infections lasted 2-4 months.…”

Fungous Diseases of Britain

“…In the United States, hyperkeratotic flexion crease infections of the palms have been recorded less frequently than in this country (Silva et al, 1955). Disease may present as patches of acute vesicular and crusted eczema, and fungous infection is thought of only belatedly.…”