Fungous Diseases of Britain

Riddell, R. W.

doi:10.1136/bmj.2.4996.783

Cited by 21 publications

(4 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nystatin is essentially for local use and has been of value in infections involving the pleural cavity (Manning and Robertson, 1959). Its use, however, may be extended to pulmonary infection by means of aerosol inhalations (Riddell, 1956), or intrabronchial instillations (Ragaini and Tosi, 1959). The newer polyene antibiotic, natamycin, is similarly confined to topical use and has also been of value as an aerosol in non-invasive forms of bronchopulmonary aspergillosis (Edwards and La Touche, 1964).…”

Section: Discussionmentioning

confidence: 99%

Fatal acute pulmonary aspergillosis in two children of one family.

Strelling¹,

Rhaney²,

Simmons³

et al. 1966

Archives of Disease in Childhood

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Fatal acute pulmonary aspergillosis in two children of one family.

Strelling¹,

Rhaney²,

Simmons³

et al. 1966

Archives of Disease in Childhood

View full text Add to dashboard Cite

“…The patient showed progressive radiological improvement over the space of nine months. Riddell (1956) mentions the efficacy of inhalations of nystatin, brilliant green, or hydroxystilbamidine in A. fumigatus infections, but his paper was not published until after the death of our patient.…”

Section: Discussionmentioning

confidence: 99%

Broncho-pulmonary Aspergillosis

Stevenson¹,

Reid²

1957

BMJ

View full text Add to dashboard Cite

“…The first published report regarding the administration of antifungals by aerosol dates back to 1956 when nystatin aerosol was suggested to be effective in the elimination of Aspergillus fumigatus from bronchial secretions [16]. Data from eight dogs and one human patient following AmBd inhalations were first reported in 1959 [17], followed by a report of aerosolised nystatin and amphotericin B use in 1975 [18].…”

Section: Aerosolsmentioning

confidence: 98%

Novel modes of antifungal drug administration

Arthur¹,

Drew²,

Perfect³

2004

Expert Opinion on Investigational Drugs

View full text Add to dashboard Cite

Administration of antifungals by routes other than that for which the agent was designed or approved have been utilised in attempts to provide directed therapy, reduce adverse effects and improve drug penetration into selected infection sites, such as the central nervous system, lungs and peritoneum. The most widely investigated agent utilising a novel method of drug delivery is amphotericin B. Dose forms for this agent include topicals (aerosol, nasal spray, irrigations, pastes, absorbable sponges, impregnated bone cement and gelatin), oral dosage forms (solutions, suspensions, tablets and so on) and ophthalmic preparations (drops, ointments and injections). Amphotericin B has been administered by routes such as oral, endobronchial, intrathecal, intracisternal, intra-articular, intraperitoneal, ophthalmic and as an antibiotic 'line lock'. Nystatin has been administered as an aerosol, percutaneous paste and bladder washes. Azoles, such as miconazole, fluconazole, ketoconazole and posaconazole, have been administered by novel methods but to a lesser degree. Most of these reports involve miconazole. The dose forms and routes of administration for azoles have included irrigants (bladder, joint), ophthalmic preparations (eye drops, intraocular injections, ointments), impregnated bone cement, endobronchial and intrathecal administration. Finally, both methylene blue (bladder washes) and flucytosine (peritoneal lavage, ophthalmic eye drops) have also been employed. Adequate evaluations of both the safety and efficacy of these therapies are most often hindered by prior or concomitant antifungal therapies, comorbidities and the lack of controlled clinical trials. In addition, the availability of newer treatment options, which demonstrate significant improvement in drug distribution and treatment-related adverse effects make many such novel modes of administration less practical or necessary. In contrast, the inhalation of antifungal aerosols, such as amphotericin B, is rapidly becoming a viable prophylactic option.

show abstract

Fungous Diseases of Britain

Cited by 21 publications

References 28 publications

Fatal acute pulmonary aspergillosis in two children of one family.

Fatal acute pulmonary aspergillosis in two children of one family.

Broncho-pulmonary Aspergillosis

Novel modes of antifungal drug administration

Contact Info

Product

Resources

About