Trichophyton mentagrophytes tinea faciei in acromegaly patient: Case report

Merad, Yassine; Derrar, Hichem; Habib, M. Hadj; Belkacemi, Malika; Talha, Kheira; Sekouhi, Mounia; Belmokhtar, Zoubir; Adjmi-Hamoudi, Haiet

doi:10.1016/j.jecr.2021.100079

Cited by 4 publications

(4 citation statements)

References 11 publications

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“…They have greater toxic side effects encountered with traditional systemic therapy (Kumar et al., 2014 ). Tinea corporis, also known as ringworm, is a dermatophytosis (superficial fungal infection especially on the skin) (Merad et al., 2021 ). The therapeutic efficacy of medication applied topically is mainly determined by its capability to enter and penetrate the skin.…”

Section: Introductionmentioning

confidence: 99%

Fenticonazole nitrate loaded trans-novasomes for effective management of tinea corporis: design characterization, in silico study, and exploratory clinical appraisal

Albash

Ragaie

Hassab³

et al. 2022

Drug Delivery

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The current investigation aimed for loading fenticonazole nitrate (FTN), an antifungal agent with low aqueous solubility, into trans-novasomes (TNs) for management of tinea corporis topically. TNs contain Brij ® as an edge activator besides the components of novasomes (cholesterol, Span 60, and oleic acid) owing to augment the topical delivery of FTN. TNs were fabricated applying ethanol injection method based on D-optimal experiment. TNs were evaluated with regard to entrapment efficiency percent (EE%), particle size (PS), polydispersity index (PDI), and zeta potential (ZP). Further explorations were conducted on the optimum formulation (F7). F7 showed spherical appearance with EE%, PS, PDI, and ZP of 100.00 ± 1.10%, 358.60 ± 10.76 nm, 0.51 ± 0.004, and −30.00 ± 0.80 mV, respectively. The in silico study revealed the ability of the FTN–cholesterol complex to maintain favorable interactions throughout the molecular dynamics simulation (MDS) study. Moreover, Trichophyton mentagrophytes growth was inhibited effectively by F7 than by FTN suspension applying 2,3-bis(2-methyloxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) reduction assay. Furthermore, a clinical appraisal on patients with tinea corporis fungal lesions confirmed the superiority of F7 compared to Miconaz ® cream in the magnitude of clinical cure of tinea corporis. Thereby, TNs could be considered as promising vesicles for enhancing the antifungal potential of FTN for the topical management of tinea corporis.

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Section: Introductionmentioning

confidence: 99%

Fenticonazole nitrate loaded trans-novasomes for effective management of tinea corporis: design characterization, in silico study, and exploratory clinical appraisal

Albash

Ragaie

Hassab³

et al. 2022

Drug Delivery

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“…Tinea faciei due to Trichophyton mentagrophytes has been reported in an acromegaly patient under corticosteroids treatment (Figure 7) [171].…”

Section: Atypical Tinea Facieimentioning

confidence: 99%

Atypical and Unpredictable Superficial Mycosis Presentations: A Narrative Review

Belmokhtar,

Djaroud,

Matmour

et al. 2024

JoF

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While typically exhibiting characteristic features, fungal infections can sometimes present in an unusual context, having improbable localization (eyelid, face, or joint); mimicking other skin diseases such as eczema, psoriasis, or mycosis fungoides; and appearing with unexpected color, shape, or distribution. The emergence of such a challenging clinical picture is attributed to the complex interplay of host characteristics (hygiene and aging population), environment (climate change), advances in medical procedures, and agent factors (fungal resistance and species emergence). We aim to provide a better understanding of unusual epidemiological contexts and atypical manifestations of fungal superficial diseases, knowing that there is no pre-established clinical guide for these conditions. Thus, a literature examination was performed to provide a comprehensive analysis on rare and atypical superficial mycosis as well as an update on certain fungal clinical manifestations and their significance. The research and standard data extraction were performed using PubMed, Medline, Scopus, and EMBASE databases, and a total of 222 articles were identified. This review covers published research findings for the past six months.

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“…Tinea faciei due to Trichophyton mentagrophytes has been reported in Acromegaly patient under corticosteroids treatment [158]. (Figure 6) Tinea auricularis was used to design ear infection which is current by the species Microsporum canis, Trichophyton rubrum [87,94], tinea labialis is also rarely used.…”

Section: Atypical Tinea Facieimentioning

confidence: 99%

Atypical and Unpredictable Superficial Mycosis Presentations: A Narrative Review

Belmokhtar,

Djaroud,

Matmour

et al. 2024

Preprint

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While typically exhibiting characteristic features, fungal infections can sometimes present in an unusual context, having improbable localization (eyelid, face, joint), mimicking other skin diseases such as eczema, psoriasis, or mycosis fungoides, and appearing with unexpected color, shape, or distribution. The emergence of such a challenging clinical pictures is attributed to complex interplay of host characteristics (hygiene, aging population), environment (climate change), advances in medical procedures, and agent factors (fungal resistance, species emergence). We aim to provide a better understanding of unusual epidemiological contexts and atypical manifestations of fungal superficial diseases, knowing that there is no pre-established clinical guide for these conditions.

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Trichophyton mentagrophytes tinea faciei in acromegaly patient: Case report

Cited by 4 publications

References 11 publications

Fenticonazole nitrate loaded trans-novasomes for effective management of tinea corporis: design characterization, in silico study, and exploratory clinical appraisal

Fenticonazole nitrate loaded trans-novasomes for effective management of tinea corporis: design characterization, in silico study, and exploratory clinical appraisal

Atypical and Unpredictable Superficial Mycosis Presentations: A Narrative Review

Atypical and Unpredictable Superficial Mycosis Presentations: A Narrative Review

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