Trichophyton Asthma

Platts-Mills, Thomas A.E.; Woodfolk, Judith A.

doi:10.1378/chest.09-0114

Cited by 13 publications

(9 citation statements)

References 11 publications

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“…That study demonstrated clinical improvement, decreased steroid use, and decreased sensitivity of the lungs to Trichophyton . There have been many other reports of the association between Trichophyton sensitivity and asthma, including a striking report from Japan, which also showed a connection between higher titre IgE antibodies to Trichophyton and severity of asthma . Further progress in this area would require a multicenter controlled trial of the use of itraconazole to treat dermatophyte infection in cases of severe asthma .…”

Section: The Relevance Of Fungal Allergens To Severe Asthmamentioning

confidence: 83%

The role of allergy in severe asthma

Kennedy

Heymann

Platts-Mills

2012

Clin Experimental Allergy

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Summary The classification of asthma to identify forms which have different contributing causes is useful for all cases in which the disease requires regular treatment, but it is essential for the management of severe asthma. Many forms of the disease can occur, and complex mixtures are not uncommon; here we artificially separated the cases into four groups: i) inhalant allergy, ii) fungal sensitization with or without colonization (including ABPA); iii) severe sinusitis with or without aspirin-exacerbated respiratory disease (AERD), and iv) non-inflammatory cases, including those associated with severe obesity and vocal cord dysfunction (VCD). The reason for focusing on these groups is because they illustrate how much the specific management depends upon correct classification. Inhalant allergy can present as chronically severe asthma. However, severe attacks of asthma requiring hospital admission can occur in cases which are generally only mild or moderate. The best recognized and probably the most common cause of these acute episodes is acute infection with a rhinovirus. Recent evidence suggests that high titer IgE, particularly to dust mite, correlates to exacerbations of asthma related to rhinovirus infection. While it is well recognized that the fungus Aspergillus can colonize the lungs and cause severe disease, it is less well recognized that those cases may not have full criteria for diagnosis of ABPA or may involve other fungi. Identifying fungal cases is important, because treatment with imidazole antifungals can provide significant benefit. Taken together, specific treatment using allergen avoidance, immunotherapy, anti-IgE, or antifungal treatment is an important part of the successful management of severe asthma, and each of these requires correctly identifying specific sensitization.

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Section: The Relevance Of Fungal Allergens To Severe Asthmamentioning

confidence: 83%

The role of allergy in severe asthma

Kennedy

Heymann

Platts-Mills

2012

Clin Experimental Allergy

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“…We have already reported successful therapy using amphotericin B aerosol with fewer side effects in atopic cough [8]. In spite of the availability of antifungal drugs [9], our case reports suggested that disease recurrence in both AFC [10] and ABPM [7] was influenced by the existence of related fungi in the patients' environment. Successful strategies including environmental management may be established by resolving further problems -Does the detected fungus obtained from the bronchial specimen really sensitize the patient via colonization by this fungus?…”

mentioning

confidence: 83%

Role of fungal colonization for sensitization in asthma

Ogawa

Fujimura

Takeuchi

et al. 2012

Clin Experimental Allergy

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“…Therefore, testing in adults with asthma that does not respond to first-line treatment should include not only such routine investigation as lung function, sinus CT scanning, sensitization to common inhalant allergens or evaluation of evidence for allergic bronchopulmonary aspergillosis (ABPA) [4], but should also include an evaluation for evidence of colonization with a range of fungi including Alternaria, Candida, and Trichophyton as well as Aspergillus species [5].…”

Section: Introductionmentioning

confidence: 99%

Two cases of Schizophyllum asthma: Is this a new clinical entity or a precursor of ABPM?

Ogawa

Fujimura

Takeuchi

et al. 2011

Pulmonary Pharmacology & Therapeutics

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Abstract(Background) There is a close link between fungal sensitization and asthma severity.Though Schizophillum commune (S. commune, called"suehirotake"in Japanese), one of the basidiomycetous (BM) fungi, is a fungus that can cause allergic bronchopulmonary mycosis (ABPM) and allergic fungal sinusitis (AFS), whether the fungus causes or sensitizes the asthma is unclear. (Methods) The bronchial provocation test using S. commune may be a causative fungal antigen of bronchial asthma.

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Trichophyton Asthma

Cited by 13 publications

References 11 publications

The role of allergy in severe asthma

The role of allergy in severe asthma

Role of fungal colonization for sensitization in asthma

Two cases of Schizophyllum asthma: Is this a new clinical entity or a precursor of ABPM?

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