Trichomegaly in a 3‐Year‐Old Girl with Alopecia Areata

Abstract

We report here a case of bilateral trichomegaly associated with alopecia areata in a 3-year-old girl, healthy except for mild atopic dermatitis. Trichomegaly is a rare condition and, in many cases, is a side effect of medication such as ophthalmic solution prostaglandin analogs and epidermal growth factor receptor inhibitors. Trichomegaly has also been associated with acquired medical conditions such as HIV, systemic lupus erythematosus, anorexia nervosa, porphyria cutanea tarda, hypothyroidism, and dermatomyositis. In very rare circumstances, trichomegaly has been described as part of congenital conditions such as Oliver-McFarlane syndrome. We believe that the development of bilateral trichomegaly in conjunction with alopecia areata in this patient represents a novel finding as it occurred in the absence of any significant health problems, congenital abnormalities, or medications.

Characterization of anin vivomodel for the study of eyelash biology and trichomegaly: mouse eyelash morphology, development, growth cycle, and anagen prolongation by bimatoprost

“…While the PGF 2α analogue latanoprost failed to recover human eyebrows in alopecia areata, 49 it stimulated the regrowth of eyelashes in alopecia areata 15,50 . Trichomegaly may occur with other hairy regions remaining unaffected, 9,51 or even concurrently with alopecia areata 52 . Taken together, studies on mouse back pelage hairs could potentially provide misleading information on eyelash follicles.…”

Essential trichomegaly: case report

“…AIDS is among the well-studied systemic causes of trichomegaly (1) , although primarily described during later disease stages. Nazareth et al (11) documented 23 medications associated with tri chomegaly. The most common were prostaglandin analogs, cyclosporine, interferon, topiramate and cetuximab.…”

“…Two cases of symptomatic trichomegaly without any associated systemic disorder are presented in this paper. Nazareth et al (11) documented 23 medications associated with tri chomegaly. The most common were prostaglandin analogs, cyclosporine, interferon, topiramate and cetuximab.…”

Eyelashes: Anatomical and Physiological Features, Eyelash Loss and Trichomegaly: Review

“…24 Trikomegali ile ilişkisi tam netlik kazanmayan, literatürde birlikteliği nadir olgular şeklinde rapor edilen durumlar arasında malnütrisyon, alopesi areata, sistemik lupus eritematozus, dermatomiyozit ve metastatik renal adenokarsinom yer almaktadır. [35][36][37][38][39] Bu durumlardaki trikomegalinin koinsidental olup olmadığı netlik kazanmamış-tır. 24 Ayrıca, bazı kaynaklarda porfiri, akrodini, hipotiroidi, POEMS sendromu, anoreksi nevroza, linear skleroderma, hepatopati, Kala-azar ve gebelik gibi durumların trikomegali ile ilişkili olabileceği belirtilse de bunlarla ilgili çalışma ya da olgu raporu şeklinde yeterli literatür kanıtı yoktur.…”