Characterization of anin vivomodel for the study of eyelash biology and trichomegaly: mouse eyelash morphology, development, growth cycle, and anagen prolongation by bimatoprost

Abstract

This study shows that mouse eyelashes offer an excellent in vivo model for the quantitative and qualitative analysis of eyelash morphology, development, growth cycle, exogen and pharmacological modulation. This model will help to elucidate the unknown molecular controls of eyelash growth, and to develop novel drugs to treat eyelash disorders.

International Union of Basic and Clinical Pharmacology. LXXXIII: Classification of Prostanoid Receptors, Updating 15 Years of Progress

“…This pharmacology was entirely consistent with that observed for the prostamide receptor in ocular cells and isolated tissue preparations Woodward et al, 2003Matias et al, 2004;Spada et al, 2005;Wan et al, 2007;Stamer et al, 2010). Therapeutic uses for the prostamide F 2␣ mimetic bimatoprost have extended beyond glaucoma to include trichomegaly (Tauchi et al, 2010). No potential medical uses for prostamide antagonists ) have been reported.…”

Recent Progress in Prostaglandin F2αEthanolamide (Prostamide F2α) Research and Therapeutics

“…It increases eyelash number in follicles without follicle neogenesis in rodents (Tauchi et al, 2010). In a detailed morphometric analysis of bimatoprost-treated mouse eyelashes, eyelash thickening occurred but only in eyelashes of short and medium length (Tauchi et al, 2010). A significant increase in the percentages of follicles in anagen phase was apparent, with a significant decrease in follicles in the telogen and late catagen phases (Tauchi et al, 2010).…”

“…In a detailed morphometric analysis of bimatoprost-treated mouse eyelashes, eyelash thickening occurred but only in eyelashes of short and medium length (Tauchi et al, 2010). A significant increase in the percentages of follicles in anagen phase was apparent, with a significant decrease in follicles in the telogen and late catagen phases (Tauchi et al, 2010). In recent studies, bimatoprost dose dependently prolonged anagen in human scalp follicles in vitro and stimulated the initiation of anagen of rodent pelage follicles in vivo Khidhir et al, 2013).…”

“…It stimulates melanogenesis but with no change in melanocyte proliferation or prostaglandin-related inflammation and increases the size of the dermal papilla and hair bulb in humans (Kapur et al, 2005;Cohen, 2010). It increases eyelash number in follicles without follicle neogenesis in rodents (Tauchi et al, 2010). In a detailed morphometric analysis of bimatoprost-treated mouse eyelashes, eyelash thickening occurred but only in eyelashes of short and medium length (Tauchi et al, 2010).…”

Eyelashes: Anatomical and Physiological Features, Eyelash Loss and Trichomegaly: Review

“…24 Fare modellerinde prostaglandin F 2α ve latanoprostun kıl foliküllerini ve foliküler melanositleri stimüle ettiği, kıl folikül-lerini telojen fazdan anajen faza soktuğu ve anajen fazı uzattığı gösterilmiştir. 7,34 Çeşitli çalışmalarda, bimatoprostun latanoprosta kıyasla daha sık ve daha erken trikomegaliye neden olduğu gösteril-miştir. 24 Tablo 2'de yer alan diğer ilaçların da trikomegali ile ilişkisine dair literatür verisi mevcuttur, ancak daha önceki derlemelerde asetolazolamid, benoksaprofen, kortikosteroidler, diazoksid, minoksidil, penisilamin, psoralen, streptomisin ve sül-fat gibi ilaçların trikomegali ile ilişkili olabileceği belirtilse de bu ilişkiye dair çalışma ya da olguraporu şeklinde yeterli kanıt yoktur.…”