Trichloroacetic acid peels

Trichloroacetic Acid Versus Salicylic Acid in the Treatment of Acne Vulgaris in Dark-Skinned Patients

“…In low concentrations, TCA is a safe and reliable preparation for superficial peels. 8 It has been used for treating acne, either alone or in combination with other therapeutic agents, 9 by diminishing corneocyte cohesion and keratinocyte plugging. 10 Salicylic acid (ortho-hydroxybenzoic acid) is a betahydroxy acid used for chemical peeling.…”

Treatment of Recalcitrant Diabetic Ulcers With Trichloroacetic Acid and Fibroblasts

“…Using TCA to treat recalcitrant DFUs is a new application of this chemical compound. In this regard, it has been reported that applying TCA might accelerate the process of cell regeneration after two weeks (9,10). Stem cells, endothelial cells, and fibroblasts, either on scaffolds or as suspension, have been used to treat the ischemic DFUs.…”

Chemical burn following 50% trichloroacetic acid for acne: Presentation of a case and a focused review

“…This is followed by sloughing off of the necrotic layers and reepithelialization via germinative centers of neighboring hair follicles over the next several days. TCA peeling also promotes dermal collagen remodeling, which can continue for months (Nguyen and Rooney, 2000). TCA has a protein dissociation constant (pKa) of 0.52, making it an inherently stronger acid than AHAs (pKa of glycolic acid -3.83).…”

“…TCA in strengths of 35% or less is used for superficial peeling whereas in strengths of 35-50% it is used for medium-depth peeling. When used alone at the higher concentrations, TCA is less predictable and is associated with an increased risk of adverse events, including hypertrophic scarring (Nguyen and Rooney, 2000). For this reason, TCA at lower concentrations is often combined with other peeling agents to achieve the desired depth while minimizing the side-effect profile.…”