Treatment of Recalcitrant Diabetic Ulcers With Trichloroacetic Acid and Fibroblasts

Nilforoushzadeh, Mohammad Ali; Jaffary, Fariba; Siavash, Mansour; Heidari, Alireza; Ansari, Nazli; Siadat, Amir Hossein

doi:10.17795/jssc23312

Cited by 4 publications

(9 citation statements)

References 11 publications

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“…Nevertheless, it also needs training. Patients with diabetes need to keep between their toes dry using talcum powder and avoid the application of lotion since it is important as a hygienic measure for feet in preventing fungal infection [28]. Patients should also use skin moisturizers daily to keep the skin of their feet soft and should trim their toenails straight across (not rounded) to prevent damage to their toes [29].…”

Section: Discussionmentioning

confidence: 99%

Diabetic foot care: knowledge and practice

et al. 2020

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Background: Diabetic foot ulcers (DFUs) are common problems in diabetes. One of the most important factors affecting the quality of diabetes care is knowledge and practice. The current study aimed at determining the knowledge and practice of patients with diabetes regarding the prevention and care of DFUs. Methods: The current analytical, cross sectional study was conducted in Guilan Province (north of Iran) on 375 patients registered in the medical records as type 2 diabetes mellitus. Demographic characteristics, knowledge, and practice of participants were recorded in a questionnaire during face-to-face interviews conducted by the researcher. Descriptive and inferential statistics were performed using SPSS version18. Results: The mean score of knowledge was 8.63 ± 2.5 out of 15, indicating that the majority of participants had a poor knowledge (84.8%). The mean practice score was 7.6 ± 2.5 out of 15, indicating that a half of them had poor performance (49.6%). There was a significant and direct correlation between knowledge and practice. Knowledge level, place of residence, marital status, and history of admission due to diabetic foot were predictors of practice score. Conclusions: According to the low level of knowledge and practice in patients with diabetes regarding the prevention and care of DFUs, and considering the significant relationship of some demographics of patients with knowledge and practice scores, a targeted educational program is needed to promote knowledge of patients with diabetes.

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Section: Discussionmentioning

confidence: 99%

Diabetic foot care: knowledge and practice

et al. 2020

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“…This is a suggested protocol for wound treatment in most studies. 14,21,22 Sterile transparent cover was used for contact laser irradiation. Output laser power after passing through the cover was calculated using dosimeter.…”

Section: Laser Irradiationmentioning

confidence: 99%

Evaluation of the Effects of Low Level Laser Therapy on the Healing Process After Skin Graft Surgery in Burned Patients (A Randomized Clinical Trial)

et al. 2018

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Skin graft is the standard therapeutic technique in patients with deep ulcers, but like every surgical procedure, it may present some complications. Although several modern dressings are available to enhance comfort of donor site, the use of techniques that accelerate wound healing may enhance patient's satisfaction. Low level laser therapy (LLLT) has been used in several medical fields, especially for wound healing, but it may take several months for large ulcers treated with laser to heal completely. Nine patients with bilateral similar grade 3 burn ulcers in both hands or both feet were selected as candidates for split-thickness skin graft (STSG). One side was selected for laser irradiation and the other side as control, randomly. Laser was irradiated every day for 7 days with red 655 nm light, 150 mW, 2 J/cm at the bed of the ulcer and with infra-red 808 nm light, 200 mW for the margins. The rate of wound dehiscence after skin graft surgery was significantly lower in laser treated group in comparison to control group which received only classic dressing (P=0.019). The results showed LLLT to be a safe effective method which improves graft survival and wound healing process and decreases the rate of wound dehiscence in patients with deep burn ulcers.

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“…All wounds significantly improved in six treated patients after 7.5 -0.83 weeks, and the wound areas and infection scores reduced. In that study, 68.6-100% improvements were reported for the efficacy of treatment for patients, without any complications after 3 months of follow up 3 .…”

Section: Discussionmentioning

confidence: 86%

“…TCA is a chemical agent, which has recently been used to treat recalcitrant DFU. TCA might accelerate the process of cell regeneration after 2 weeks 7 . Evidence shows that higher TCA concentrations penetrate into the mid-reticular dermis.…”

Section: Discussionmentioning

confidence: 99%

Combination therapy of trichloroacetic acid, human autologous fibroblast injection and fibroblast seeded microfibrous collagen scaffold as a novel treatment for osteomyelitis diabetic foot ulcer

Nilforoushzadeh

Heidari‐Kharaji

Zare

et al. 2020

J of Diabetes Invest

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A severe complication associated with diabetes is diabetic foot ulcer (DFU). Most patients with DFU require amputation. Although treatment of non‐healing diabetic ulcers is challenging, the use of novel therapies can be effective. In this report, we present the case of a woman with type 2 diabetes with DFU‐related osteomyelitis, who was treated with a combination therapy of trichloroacetic acid, calcium alginate and foam dressings, human autologous fibroblast injection, and a fibroblast cell‐seeded collagen scaffold. The results showed the positive effects of combination therapy on DFU. In the initial treatment, the wound area was measured to be 14 × 7 cm2, with a depth of 4 cm. After 6 months, the wound was measured to be 1.5 cm2, showing a 90% reduction of the wound area. Overall, this combination therapy was highly effective in the treatment of DFU‐related osteomyelitis, and could markedly prevent amputation among DFU patients.

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Treatment of Recalcitrant Diabetic Ulcers With Trichloroacetic Acid and Fibroblasts

Cited by 4 publications

References 11 publications

Diabetic foot care: knowledge and practice

Diabetic foot care: knowledge and practice

Evaluation of the Effects of Low Level Laser Therapy on the Healing Process After Skin Graft Surgery in Burned Patients (A Randomized Clinical Trial)

Combination therapy of trichloroacetic acid, human autologous fibroblast injection and fibroblast seeded microfibrous collagen scaffold as a novel treatment for osteomyelitis diabetic foot ulcer

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