Trichilemmal carcinoma: an unusual presentation of a rare cutaneous lesion

Wilkie, Mark D.; Munir, Nazia; Roland, N J; Lancaster, Jeffrey

doi:10.1136/bcr-2012-008369

Cited by 10 publications

(13 citation statements)

References 18 publications

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“…7 Wide local excision has been suggested for TC but clear margins were mostly not described. 9 , 11 - 12 Mohs micrographic surgery has been reported to be a successful technique for treating malign trichilemmal tumor. 15 We treated all our patients with wide local excision with 1 cm.…”

Section: Discussionmentioning

confidence: 99%

“…Local cervical lymph node and distant metastases of TC have been rarely reported in the literature. 9 - 11 There is no optimal treatment for this neoplasm with metastases and there is no established chemotherapy regimen in the literature. We scanned our patients with cranial, cervical and thoracoabdominal CT except one because he had refused further investigations.…”

Section: Discussionmentioning

confidence: 99%

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Malignant tumor of outer root sheath epithelium, trichilemmal carcinoma: Clinical presentations, treatments and outcomes

Evrenos

Kerem²,

Temız

et al. 2018

SMJ

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Objectives:To emphasize different clinical features of tumor that can be misdiagnosed clinically.Methods:A total of 8 cases operated between September 2009 and 2016 at the Celal Bayar University, Faculty of Medicine were included in the study. Patients’ clinicopathological features, type of surgery and follow up information were evaluated.Results:Six patients were male. The average age was 75.50. The lesions were located on the head and neck, and chest wall. Six patients had a history of the rapid growth of lesion. There was no metastasis at the time of diagnosis. None of the patients needed adjuvant therapy. Mean follow up time was 19.37 months. None of the patients developed recurrence or metastasis.Conclusion:This tumor resembles basal or squamous cell carcinoma. The histopathological evaluation may lead to misdiagnosis. Regional or distant metastasis is very rare. There is no consensus about adjuvant therapy. Screening for metastasis and close follow up are mandatory.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Malignant tumor of outer root sheath epithelium, trichilemmal carcinoma: Clinical presentations, treatments and outcomes

Evrenos

Kerem²,

Temız

et al. 2018

SMJ

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“…There is no current consensus on surgical margins or follow-up for patients with TC. Wilkie et al 2 suggested using margins for cutaneous squamous cell carcinoma, specifically those that are 4–6 mm in size. Zhuang et al 16 showed improved overall survival in their study when a surgical margin of 1 cm was taken.…”

Section: Discussionmentioning

confidence: 99%

“…It has an indolent nature and typically occurs in elderly patients on areas of the body exposed to the sun 1 2. Ninety per cent of the lesions present on the scalp 3.…”

Section: Introductionmentioning

confidence: 99%

Metastatic trichilemmal carcinoma in a patient with breast cancer

2016

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Trichilemmal carcinoma (TC) is described as a very rare cancer of the skin adnexa. Ninety per cent of the lesions present on the scalp. Prognostic factors in TC are limited to lymph node status and surgical margins, with no statistical significance observed for age or gender of the patient, size of tumour or locoregional recurrence. We present a 46-year-old black patient who developed TC during treatment for breast cancer. Postoperative histology of the scalp lesion excision confirmed no involved margins. At the three monthly appointment, the patient was reviewed and multiple, new scalp lesions were noted. A CT scan of the head, neck found multiple lesions on the scalp, limited to the soft tissue, not involving the outer table of the skull. There was bilateral invasion of the parotid glands. To the best of our knowledge, no syndromes or associations between breast cancer and adnexal skin tumours exist.

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“…The distinction between trichilemmal carcinoma and SCC with clear cell features has a practical significance since the risk of metastasis for trichilemmal carcinoma is very low, unlike SCC which has higher rates of local recurrence and metastatic potential 44 45. However, histologically, the differential diagnosis may be often challenging.…”

Section: Cutaneous Adnexal Tumours With Follicular Lineagementioning

confidence: 99%

Challenges in the diagnosis of cutaneous adnexal tumours

et al. 2015

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The diagnosis of cutaneous adnexal neoplasms, a heterogeneous group of entities, is often perceived by practising pathologists as challenging. A systematic approach to diagnosis is necessary for classification of these lesions, which establishes the tumour differentiation (follicular, sebaceous, sweat gland or apocrine) and evaluates histological features differentiating between benign and malignant entities. Consideration of clinical history is a necessary adjunct in evaluation of the adnexal neoplasm, as characteristic anatomical sites are described for many adnexal lesions. In some instances, immunohistochemical studies may also be employed to aid the diagnosis. The differential diagnosis between primary cutaneous adnexal neoplasms and cutaneous metastases from visceral tumours may also be difficult. Clinical, radiological, histological and immunohistochemical characteristics will be further discussed, considering that the correct diagnosis has a significant impact on the patient's management and prognosis.

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Trichilemmal carcinoma: an unusual presentation of a rare cutaneous lesion

Cited by 10 publications

References 18 publications

Malignant tumor of outer root sheath epithelium, trichilemmal carcinoma: Clinical presentations, treatments and outcomes

Malignant tumor of outer root sheath epithelium, trichilemmal carcinoma: Clinical presentations, treatments and outcomes

Metastatic trichilemmal carcinoma in a patient with breast cancer

Challenges in the diagnosis of cutaneous adnexal tumours

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