Malignant tumor of outer root sheath epithelium, trichilemmal carcinoma: Clinical presentations, treatments and outcomes

Abstract

Objectives:To emphasize different clinical features of tumor that can be misdiagnosed clinically.Methods:A total of 8 cases operated between September 2009 and 2016 at the Celal Bayar University, Faculty of Medicine were included in the study. Patients’ clinicopathological features, type of surgery and follow up information were evaluated.Results:Six patients were male. The average age was 75.50. The lesions were located on the head and neck, and chest wall. Six patients had a history of the rapid growth of lesion. There was no metastasis at the time of diagnosis. None of the patients needed adjuvant therapy. Mean follow up time was 19.37 months. None of the patients developed recurrence or metastasis.Conclusion:This tumor resembles basal or squamous cell carcinoma. The histopathological evaluation may lead to misdiagnosis. Regional or distant metastasis is very rare. There is no consensus about adjuvant therapy. Screening for metastasis and close follow up are mandatory.

Huge Trichilemmal Carcinoma With Metastasis Presenting With Two Distinct Histological Morphologies: A Case Report

“…This malignant tumor is rare; to date, a total of 136 cases of TC have been reported (4)(5)(6)(7)(8)(9)(10). It usually has an indolent course and benign clinical evolution, and only four cases with regional and distant metastasis have been reported (11)(12)(13)(14). The most frequent metastatic organ was regional lymph nodes.…”

“…Our patient presented with ipsilateral neck metastasis. Unfortunately, the optimal treatment for this neoplasm occurring with metastasis has not yet been determined, and there is no established chemotherapy regimen to reference in the literature ( 11 ). Thus, it is very important to make an accurate diagnosis at an early stage.…”

Proliferating trichilemmal tumour of the eyelid in a 7-year-old girl

“…Since the lesion was on the eyelid, we elected to proceed with 0.5 mm of additional tissue circumferentially along the tumour edge in order to achieve both clear margins and a desired cosmetic result. Clinical follow-up has been recommended to monitor for recurrence,15 but there is no specific timeline for surveillance found in the literature. We are following our patient every 6 months for signs of recurrence.…”

Trichilemmal carcinoma in a patient with squamous cell skin cancer

“…ТЛК может иметь различную структуру -дольковую, солидную, трабекулярную. Дольки опухоли образованы крупными клетками со светлой или резко эозинофильной цитоплазмой, положительно окрашивающейся реактивом Шиффа и не окрашивающейся красителями, выявляющими муцин, границы долек часто четко очерчены ШИКпозитивной гиалиновой мембраной [15]. По периферии некоторых опухолевых структур клетки могут быть расположены палисадообразно, что требует проведения дифференциальной диагностики с базально-клеточной карциномой [16].…”

“…ТЛК чаще локализуется внутриэпидермально, однако может выявляться и инвазивный компонент, распространяющийся, порой, до подкожной жировой клетчатки. В крупных опухолях встречаются обширные поля кровоизлияний и/или участки некроза [15].…”