Tributyltin distribution in the coastal environment of Peninsular Malaysia

Tong, S. L.; Pang, F.Y.; Phang, Siew‐Moi; Lai, H. C.

doi:10.1016/0269-7491(95)00048-8

Cited by 51 publications

(22 citation statements)

References 32 publications

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“…Although the toxicology of organotin compounds in humans is not fully resolved (WHO, 1990), a related toxicity test can be extrapolated from animals to humans. Based on the observed effects of TBT on the immune function in rats with a safety factor of 100, Penninks (1993) derived a tolerable daily intake (TDI) of TBT Tong et al (1996) Thailand 1994-19953-680 Kan-atireklap et al (1998) India 1994-1995<1-150 Kan-atireklap et al (1998) Philippines 1994<1-640 Prudente (1999 a By multiplying factors 2.44 to normalize the concentrations expressed as ''Sn'' to ''TBT ion'' and 0.2 to normalize the concentrations based on ''dry weight'' to ''wet weight'' (these factors are calculated from molecular weights of Sn and TBT ion and representative moisture percentage of 80% in mollusc tissue, respectively). 0 100 200 300 400 S1 S2 S3 S4 S5 S6 S7 S8 S9 S10 S11 S12 S13 Species Mean Σ BTs (ng/g) Fig.…”

Section: Risk Assessment For the Seafoodmentioning

confidence: 99%

Butyltins compounds in molluscs from Chinese Bohai coastal waters

et al. 2006

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Concentrations of butyltin compounds including tributyltin (TBT), dibutyltin (DBT) and monobutyltin (MBT) were determined in mollusc samples from Chinese Bohai coastal sites to evaluate the extent of contamination and potential adverse effects on health. Wide existence of butyltins was found in these samples with a detection rate of up to 90%, and the concentrations of the total butyltin ( P BTs: TBT + DBT + MBT) ranged from <2.5 to 397.6 ng Sn/g wet weight (mean 63 ng Sn/g). Among BTs, TBT was the predominant compound in most of the samples, indicating ongoing usage of TBT-based antifouling agents in China. The different accumulation capabilities of BTs among various species were studied. The wide occurrence and serious pollution of BTs in seafood indicated a potential danger for the health of the local people who cared for these foods.

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Section: Risk Assessment For the Seafoodmentioning

confidence: 99%

Butyltins compounds in molluscs from Chinese Bohai coastal waters

et al. 2006

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“…A specific accumulation of organotin compounds in different tissues, particularly heart, was measured in Thais clavigera (Horiguchi et al 2012). Results from the laboratory and studies in the marine environment showed that values of bioconcentration factors ranged from a few thousands to 220 000 in molluscs (Tong et al 1996). In oysters, Waldock and Tain (1983) reported TBTbioaccumulation factors of 2 300−11 400 after 56 days of exposure.…”

Section: Discussionmentioning

confidence: 99%

Cultured heart cells from oyster : an experimental approach for evaluation of the toxicity of the marine pollutant tributyltin

Droguet

Devauchelle

Pennec

et al. 2012

Aquat. Living Resour.

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-European Community regulations on chemicals promote alternative methods to test substances presenting potential risks for the environment. In the present work, cultured atrial cells isolated from oyster (Crassostrea gigas) were used as an experimental model to investigate the toxicity of tributyltin (TBT) after short-time exposure at concentrations representative of those that can be measured in seawater, marine sediments and/or bivalves bioaccumulating this pollutant. In vitro and in vivo assays produce values of the same order of magnitude for both animal/cell survival and heart/cardiomyocyte beating rate. The survival rate of whole animals decreased from 10 −6 M TBT after 3 days. For cultured cells, the viability, evaluated using 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay, significantly decreased after two days of treatment with 10 −6 M TBT, and after six days with 10 −10 M TBT. The percentage of apoptotic cells, quantified by flow cytometry and YO-PRO r -1 iodide, a nucleic acid stain that only permeates cells that are beginning to undergo apoptosis, increased significantly in these cases. Moreover, intracellular concentration of Ca ++ had increased after 10 min of exposition to 10 −6 M, and could be associated with apoptotic processes. As patch clamp experiments showed that Ca ++ conductance was decreased, intracellular calcium increase could mainly be due to a release from internal stores. The decreases in beating rhythm could be explained by the decrease in adenosine triphosphate (ATP) production revealed by 31 P nuclear magnetic resonance (NMR) spectroscopy and confirmed by the increase of the K ATP channel conductance. The related hyperpolarization and the disturbances of the energetic metabolism were clearly related to the loss of the atrial cell contractility and viability.

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“…multi-alkylated species, is to use a non-polar solvent such as hexane (Hungerford et al, 1990;Uhler et al, 1993), benzene (Harino et al, 1992), toluene (Martínez et al, 2003), pentane (Tong et al, 1996) or dichloromethane (Cullen et al, 1990), whereas highly polar mono-and dibutyltin (MBT, DBT) or mono-and dimethyltin (MMT, DMT) compounds require complexation or acidification. Tropolone is a commonly used complexing agent, which improves the solubility of mono-and disubstituted organotins in low-polarity extracting solvents and makes for the efficient extraction of the species (Hong et al, 2002;Takeuchi et al, 2004;Yang et al, 2008).…”

Section: Extraction Of the Speciesmentioning

confidence: 99%

Speciation of trace element compounds in samples of biota from marine ecosystems

Bajger¹,

Konieczka²,

Namieśnik³

2011

Chemical Speciation & Bioavailability

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The toxicity, mobility, bioavailability and bioaccumulation of metals are dependent on the particular physico-chemical form in which the element occurs in the environment. Special attention has been paid to metals which are essential for the proper functioning of organisms if present in appropriate amounts but are toxic if in excess (i.e. Se, Cr), and also to non-essential elements (i.e. Hg, Pb, Cd, Sn and As). To assess the potential hazard to the health of marine organisms, qualitative and quantitative analyses of metal species accumulating along the food chain needs to be carried out. This paper reviews the available information on the speciation of trace elements in the food chain in marine ecosystems and the analytical tools used for acquiring reliable information in this field. Advantages and limitations of commonly used techniques indicate that all metal species in different samples need diverse extraction, separation and detection conditions. Although not recommending which procedure is the most suitable to determine a given compound, speciation analysis has the potential to be a powerful tool for the identification of trace element species in biological samples.

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Tributyltin distribution in the coastal environment of Peninsular Malaysia

Cited by 51 publications

References 32 publications

Butyltins compounds in molluscs from Chinese Bohai coastal waters

Butyltins compounds in molluscs from Chinese Bohai coastal waters

Cultured heart cells from oyster : an experimental approach for evaluation of the toxicity of the marine pollutant tributyltin

Speciation of trace element compounds in samples of biota from marine ecosystems

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