The aim of the research was to develop E-glass/jute fiber reinforced epoxy composites with an addition of Al 2 O 3 and bone powder by using hand layup technique and to compare tribological properties of these composites under similar test conditions. The wear experiments were designed according to Taguchi's (L 27) orthogonal array with three control variables such as sliding velocity, filler content and normal load. The results indicated that the normal load for Al 2 O 3 and filler content for bone powder emerged as the significant factors affecting specific wear rate of hybrid composites. An addition of 10 wt% of bone powder or Al 2 O 3 into E-glass/jute fiber reinforced epoxy composites increased the wear resistance considerably, and natural waste bone powder can be used instead of ceramic filler Al 2 O 3 in hybrid composites. After the analysis of control factors, an optimal factor setting has been suggested for specific wear rate and coefficient of friction. Further, the scanning electron microscopy (SEM) images for worn surfaces of hybrid composites were studied. Finally, a confirmation test was carried out to validate the results.