Triazoles as complexing agents: synthesis, characterization and pharmacological activities of copper complexes of 4-amino-3-mercapto-5-substituted aryl-1,2,4-triazoles

Copper(II), nickel(II), and ruthenium(III) complexes of an oxopyrrolidine-based heterocyclic ligand as anticancer agents

“…Copper is an essential cofactor in a number of enzymes and, therefore, may be less toxic than non-essential metals (platinum) [10]. A large number of copper(II) complexes have been synthesized and screened for their DNA binding efficiencies and anticancer activities [11][12][13][14][15][16]. Zhang and co-workers reported a copper-pyrrolidine dithiocarbamate complex [Cu(PDTC) 2 ], which was 10-fold more potent than cisplatin in suppressing the proliferation of BE(2)-C (human neuroblastoma) cell line.…”

Synthesis and biological activity of 1,3,4-oxa(thia)diazole, 1,2,4-triazole-5-(thio)one and S-substituted derivatives of 3-((2-carboxyethyl)phenylamino)propanoic acid

“…Activity of S-substituted derivatives of bistriazolethione 13 depends on the nature of the substituent. The free radical scavenging activity of compounds containing alkyl groups (15)(16)(17)(18)(19)(20) was approx. 50 %, whereas that of 22 containing benzyl group was only 3.61 %.…”

“…1,2,4-Triazole scaffold is yet another important pharmacophore since compounds bearing this moiety have been shown to display anti-inflammatory and analgesic [17], antitumor [18], antioxidative [19], antibacterial [13,14,20], and antifungal [21] properties. 1,2,4-Triazole derivatives, e.g., flucarbazone and amicarbazone, are used as herbicides [22].…”

“…Graphical Abstract Synthesis of compounds 2-27. R: 2,5,7,10,13,[15][16][17][18][19][20][21][22][23][24][25][26][27]3,8,4,9,12 …”

Antimicrobial Studies of novel metal complexes of 3,5-dimethyl-1H-pyrazol-1-yl phenyl methanone and 1-benzoyl-3-methyl-1H-pyrazol-5(4H)-one

“…Some workers interested in synthesizing and studying the structural aspects of metal complexes containing sulfur and nitrogen donor ligands because of their increasing physiological importance and the active role played by certain metal ions coordinated to them [1,2,3]. Various derivatives of 1, 3, 4-triazoles, thiadiazoles, and substituted pyrazoles have shown antitubercular [4], bacteriostatic [5], antibacterial [6] antifungal [7], anti-inflammatory [8] activities. Most of the transition metal complexes are colored and their colors are different from the transition metal salts and the ligands, then this is an important indication to the occurrence of coordination [9].…”