Triaryl methane derivatives as antiproliferative agents

Inclusion complexes of hydroxypropyl-β-cyclodextrin with novel cytotoxic compounds: Solubility and thermodynamic properties

“…In the last few years scientists' attention has been attracted by compounds containing a triphenylmethane fragment [1][2][3][4][5]. Among such compounds they found substances with antiproliferative activity.…”

Clotrimazole as a Cancer Drug:A Short Review

“…Small molecules containing the triphenylmethyl motif has demonstrated potent anticancer properties [24,35-38]. All of these triphenylmethyl analogues induce cell cycle arrest in melanoma and other cancer cell lines by inhibiting cellular growth in G 1 - or M-phases [39]. Like S-trityl-L-cysteine, clotrimazole has no effect on tubulin polymerization which reduces the side effects observed compared with other classes of chemotherapeutic drugs [35].…”

Solvent-free and One-pot Synthesis of Trisubstituted Methanes Containing Coumarin Catalysed by Yttrium(III) Nitrate

“…Therefore, the catalyst loading was gradually increased from 5 to 10 mol%. It was found that 10 mol% of Y(NO 3 ) 3 . 6H 2 O is the optimal amount to carry out the reactions in the shortest duration.…”

“…A mixture of aryl glyoxal (1 mmol), benzamide (1.1 mmol), and Y(NO 3 ) 3 . 6H 2 O (10 mol%) was stirred and heated at 80 °C for 30 min.…”

“…3 Substituted methanes containing coumarin such as warfarin, phenprocoumon, coumatetralyl, carbochromen, bromadialone and dicoumarol are anticoagulant drugs. 4 They also exhibit a wide range of biological activities such as antibacterial, anti-HIV, antiviral, anticoagulant, and antioxidant.…”