Triamcinolone Acetonide in the Treatment of Perennial Allergic Rhinitis: A post hoc Analysis of Quality of Life during a Phase III Study

Abstract

<b><i>Introduction:</i></b> Allergic rhinitis (AR) is a disease that affects ≤24% of people in Russia, significantly impairing quality of life (QoL). Intranasal corticosteroids, such as triamcinolone acetonide (TAA), are considered effective drugs for treatment. A post hoc analysis of data (phase III NASANIF trial) examined weekly QoL changes in patients receiving TAA for the treatment of perennial AR (PAR). <b><i>Methods:</i></b> NASANIF (NCT03317015) was a double-blind, parallel group, multicenter, prospective, noninferiority, phase III clinical trial. Patients with PAR were randomized (1:1) to receive TAA or fluticasone propionate (FP) for 4 weeks. Here, a post hoc analysis measures QoL using a shortened Rhinoconjunctivitis Quality of Life Questionnaire (miniRQLQ). Differences in miniRQLQ score were evaluated using a mixed linear model and descriptive statistics. A subgroup analysis was performed in patients with a previous diagnosis of allergic conjunctivitis. <b><i>Results:</i></b> Of 260 patients eligible for randomization, 128 each completed treatment with TAA or FP. Overall and individual domain scores progressively improved and were significantly different versus baseline at week 4 in both treatment groups: LS mean difference TAA: −30.92 (95% CI [−33.01 to −28.83]), <i>p</i> < 0.001, and FP: −31.13 (−33.23 to −29.04), <i>p</i> < 0.001. In both arms of the subgroup, there was a significant reduction in eye symptoms. There was no significant difference between the TAA and FP treatment groups in any analyses. <b><i>Conclusions:</i></b> TAA is effective in improving overall and individual domains of QoL in patients with PAR, over 4 weeks. Patients with a previous diagnosis of allergic conjunctivitis experienced significant improvements in QoL related to the resolution of these symptoms.

Triamcinolone Acetonide in the Treatment of Perennial Allergic Rhinitis: A post hoc Efficacy Analysis of a Phase III Study Performed in Russia

“…As well as having a rapid onset of action, effective pharmacotherapies for AR must provide symptom improvement that is sustained for the duration of treatment. Furthermore, we have shown that TAA treatment significantly improves the quality of life of PAR patients (Karaulov et al [16], submitted). This post hoc analysis assessed the improvement of PAR symptom scores in patients treated with TAA or FP over 4 weeks, although further studies will be needed to determine if this effect can be sustained over a longer period despite positive early indications.…”

Интраназальный Триамцинолона Ацетонид Эффективно Облегчает Назальные Симптомы И Улучшает Качество Жизни Пациентов С Круглогодичным Аллергическим Ринитом

“…Было показано, что оба варианта лечения эффективно снижали балльную оценку rTNSS [2]. В двух недавних публикациях были представлены результаты ретроспективного анализа эффективности [3] и качества жизни (КЖ) [4] в течение 28-дневного курса обоих вариантов лечения.…”