Trials of a computer-controlled colour vision test that preserves the advantages of pseudoisochromatic plates

Reffin, Jeremy; Astell, Susan; Mollon, J. D.

doi:10.1007/978-94-011-3774-4_9

Cited by 45 publications

(26 citation statements)

References 8 publications

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“…The transduced-and wild-type cones were randomly intermixed in a relatively smooth mosaic. Before treatment, monkeys were trained to perform a computer-based color vision test, the Cambridge Colour Test (Reffin et al 1991;Regan et al 1994), which had been modified for use with animals ( Fig. 2) (Mancuso et al 2006).…”

Section: Gene Therapy With L Opsin In Dichromatic Squirrel Monkeysmentioning

confidence: 99%

Curing Color Blindness--Mice and Nonhuman Primates

Neitz

2014

Cold Spring Harbor Perspectives in Medicine

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Section: Gene Therapy With L Opsin In Dichromatic Squirrel Monkeysmentioning

confidence: 99%

Curing Color Blindness--Mice and Nonhuman Primates

Neitz

2014

Cold Spring Harbor Perspectives in Medicine

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“…For this study, the Cambridge Colour Test was used to present Landolt C patterns (2-16 cd/m 2 ) on a calibrated computer monitor by using a video board with 15-bit resolution. The subject's task was to detect the location of the gap in a Landolt C with the use of a 4-alternative forced choice based on the principles of pseudo-isochromatic plates (34). Discrimination thresholds were defined by the minimum chromatic contrast required for detection of stimuli varied in terms of the stimulation of short-wave (tritan), middle-wave (deutan), and long-wave (protan) sensitive cones.…”

Section: Color Discriminationmentioning

confidence: 99%

Lutein, zeaxanthin, macular pigment, and visual function in adult cystic fibrosis patients

C¹,

Olano-Martín²,

Gerth³

et al. 2004

American Journal of Ophthalmology

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Background: Pancreatic insufficiency in cystic fibrosis (CF), even with replacement pancreatic enzyme therapy, is often associated with decreased carotenoid absorption. Because the macular pigment of the retina is largely derived from 2 carotenoids, lutein and zeaxanthin, the decreased serum concentrations seen in CF may have consequences for ocular and retinal health Objectives: Our aims were to determine plasma carotenoid concentrations, determine absorption and distribution of macular pigment, and assess retinal health and visual function in CF patients. Design: In 10 adult CF patients (ages 21-47 y) and 10 age-and sex-matched healthy control subjects, we measured macular pigment density in vivo, measured serum lutein and zeaxanthin concentrations, and comprehensively assessed visual performance (including contrast sensitivity, color discrimination, and retinal function) under conditions of daylight illumination. Results: Serum lutein and zeaxanthin were significantly reduced (P 0.005) in CF patients (x Ȁ SD: 87 Ȁ 36.1 and 27 Ȁ 15.8 nmol/L, respectively) compared with control subjects (190 Ȁ 72.1 and 75 Ȁ 23.6 nmol/L, respectively). Although macular pigment optical density was significantly lower (P 0.0001) in the CF group (0.24 Ȁ 0.11) than in the control group (0.53 Ȁ 0.12), no significant differences in visual function were observed. Conclusions: Adults with CF have dramatically low serum and macular concentrations of carotenoids (lutein and zeaxanthin), but their ocular status and visual function are surprisingly good. The clinical implications of low plasma concentrations of carotenoids in CF are yet to be clarified.

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“…Cut-off filters do seem to increase low contrasts when compared with grey filters (20% increments for 0.1 contrast whereas no differences are found for contrasts greater than 0.6) 4 . On the other hand, slight contrast sensitivity increments have been found in mesopic and, more perceptibly, photopic levels Colour vision of the observers was assessed with and without the tinted lenses using CRS's Colour Vision Test [26][27][28] . The discrimination threshold from white , ensured that the test was detected only if a colour difference between test and background was perceived.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Contrast Sensitivity and Losses of Chromatic Discrimination with Tinted Lenses

Sáiz

Luque

Viqueira

2002

Optometry and Vision Science

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iii) Results. The results show that the green, brown and blue filters, do not cause significant changes in contrast sensitivity when compared with a grey filter of equal luminance, although chromatic discrimination is disturbed. Yellow and orange filters improve achromatic contrast at certain spatial frequencies, but impair chromatic discrimination. iv) Conclusions. Compared to grey filters of the same luminance, yellow filters may be useful when enhancement of low achromatic contrasts is desirable, although overall brightness decrements may occur. Nevertheless, these lenses cause tritanlike defects with discrimination losses increasing with the cut-off wavelength.

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Trials of a computer-controlled colour vision test that preserves the advantages of pseudoisochromatic plates

Cited by 45 publications

References 8 publications

Curing Color Blindness--Mice and Nonhuman Primates

Curing Color Blindness--Mice and Nonhuman Primates

Lutein, zeaxanthin, macular pigment, and visual function in adult cystic fibrosis patients

Enhancement of Contrast Sensitivity and Losses of Chromatic Discrimination with Tinted Lenses

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