Trial of artificial diet in treatment of cystic fibrosis of pancreas.

Barclay, R P; Shannon, R S

doi:10.1136/adc.50.6.490

Cited by 6 publications

(3 citation statements)

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“…According to previous observations concern ing the effect of protein hydrolysates in CF (7), nitrogen absorption, to a greater extent than fat absorpt ion, tends to normalize with the semielemental diet. There is a close correlation between improvement of fat and nitrogen absorption.…”

Section: Discussionmentioning

confidence: 93%

“…In selected cases, an artificial diet may improve absorptio n (6,7) . The diets previously proposed consisted of beef seru m hydrolysate, glucose polymers, and medium-chain triglyceri de (MCT) (6)(7)(8) .…”

mentioning

confidence: 99%

“…Some commercially available formulas made of casein hydrolysate and MCT have been widely used . Casein hydrolysates are well absorbed in CF and can reduce the feca l nitrogen content to within nor mal range (7) . Substitution of MCT for long-chain fats was shown to be benefici al to CF patient s in redu cing the bulk and frequ ency of stoo ls, althoug h no signif-and nitrogen absorption, leading to a significant gain in weight when fed on semielemental diet compared with standard diet.…”

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confidence: 99%

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Absorption of a New Semielemental Diet in Infants with Cystic Fibrosis

Canciani,

Mastella

1985

J. pediatr. gastroenterol. nutr.

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Summary:A new semielemental formula made up of whey protein hydrolysate, medium‐chain triglyceride as 50% of fat, and glucose polymer was studied in 21 cystic fibrosis infants to determine whether its intestinal absorption was better than that of standard milk‐based formula. Each experiment lasted 10 days, during which the patient was fed for 5 days on one formula and immediately afterwards for 5 days on the alternative formula, without any pancreatic enzyme replacement. Fat and nitrogen absorption were assessed by 3‐day balance studies, stool fat was assayed by a modified Van de Kamer method, and stool nitrogen by an automatic method. Ten infants with very severely impaired digestive function (coefficient of fat absorption on normal diet ≤75%) showed a highly significant improvement in fat and nitrogen absorption, leading to a significant gain in weight when fed on semielemental diet compared with standard diet. No significant improvement was observed in fat and nitrogen absorption or in weight gain in the 11 infants with less severe malabsorption (coefficient of fat absorption on normal diet >75%). These results were obtained over a short period and have to be confirmed over a prolonged period of study with pancreatic enzyme supplementation. However, they suggest that such a semielemental diet should be effective for short‐term treatment in selected CF infants who have difficulty in starting to thrive adequately.

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Section: Discussionmentioning

confidence: 93%

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confidence: 99%

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