“…Infants with CF will benefit greatly from early identification of pancreatic insufficiency [45,63] and with new, simplified, validated methods for classification available [64,65], aggressive nutritional management, including PERT (as needed), vitamin, and salt supplementation, is essential. Although the choice of formula or breast milk is probably inconsequential [66][67][68], breast-fed babies may require additional supplements. Well-nourished infants will likely benefit most from new therapies, as the association between early nutritional and lung growth and function, and therefore mortality, are well established [69].…”