Trends over time in congenital malformations in live‐born children conceived after assisted reproductive technology

Henningsen, Anna-Karina Aaris; Bergh, Christina; Skjærven, Rolv; Tiitinen, Aila; Wennerholm, Ulla-Britt; Romundstad, Liv Bente; Gissler, Mika; Opdahl, Signe; Andersen, Anders Nyboe; Lidegaard, Øjvind; Forman, Julie Lyng; Pinborg, Anja

doi:10.1111/aogs.13347

Cited by 33 publications

(42 citation statements)

References 30 publications

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“…In our retrospective study, the rates of stillbirths and neonatal deaths were not significantly different between the two groups and within the range reported in the literatures. Notably, birth defects were a problem, and the major congenital malformations in newborns conceived by ART were not significantly different from those of newborns who were spontaneously conceived (Henningsen et al, 2018). However, there were significant differences in some birth defects, especially congenital heart defects, among newborns conceived by ART compared with those spontaneously conceived (Giorgione et al, 2018; Hoorsan et al, 2017; Iwashima, Ishikawa, & Itoh, 2017; Patil et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Effects of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional IVF cycles

Chen

Liu

et al. 2020

Andrologia

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The present study assessed the influences of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional in vitro fertilisation cycles. This retrospective study analysed 427 and 2,728 cycles from the normal sperm morphology rate <4% and ≥4% group respectively. The clinical (total fertilisation failure, clinical pregnancy, implantation and abortion) and neonatal (sex, gestational age, preterm birth, birthweight, low birth weight, live births and birth defects of newborns) outcomes were compared. The rate of total fertilisation failure in the normal sperm morphology rate <4% group was significantly higher compared with that in the normal sperm morphology rate ≥4% group (2.8% versus 1.2%, p = .012). Total fertilisation failure was completely resolved by early rescue intracytoplasmic sperm injection. The clinical pregnancy, implantation and abortion rates were not significantly different between the two groups. Additionally, the sex, preterm birth, low birth weight, live births and birth defect rates, gestational age and birthweight of newborns were not significantly different between the two groups. Thus, normal sperm morphology rate <4% significantly increased the total fertilisation failure rate but did not affect the clinical or neonatal outcomes.

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Section: Discussionmentioning

confidence: 99%

Effects of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional IVF cycles

Chen

Liu

et al. 2020

Andrologia

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“…No difference was reported between ART twins and SC twins. During the time period 1988-2007, the RR of a major birth defect between ARTchildren and SC-children remained unchanged with the most common birth defect being cardiovascular defects (Henningsen et al 2018).…”

Section: Birth Defectsmentioning

confidence: 99%

The health of children conceived by ART: ‘the chicken or the egg?’

Berntsen

Söderström‐Anttila

Wennerholm

et al. 2019

Human Reproduction Update

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307

226

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Long-term health Neurodevelopmental health Cardiovascular function and metabolism Growth Respiratory and allergic disorders Malignancies Reproductive health Controlled ovarian stimulation Laboratory factors Culture media Culture time Number of embryos transferred Oocyte donation and gestational surrogacy Oocyte vitrification Epigenetics Imprinting disorders The chicken or the egg? Subfertility and sibling studies Future research Conclusion The conclusion we can reach from the well designed studies aimed at disentangling the influence on child health of parental and ART factors is that both the chicken and the egg matter.

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“…A Nordic cohort study from the CoNARTaS comparing ART singletons (n ¼ 62,379) with singletons born after spontaneous conception (n ¼ 362,215) observed an increased risk for major birth defects (3.4% versus 2.9%; aOR 1.14, 95% CI 1.08-1.20) (53). Increased rates of birth defects occurred in different organ systems: central nervous system; eye; ear, face, and neck; heart; gastrointestinal system; urinary system; and the musculo-skeletal system, with congenital heart defects being the most common defects.…”

Section: Art Versus General Populationmentioning

confidence: 99%

“…Another study from the CoNARTaS group assessed the risk of major birth defects and the risk over time between 1988 and 2007 in ART singletons compared with spontaneously conceived singletons (53). The rate of children born with a major birth defect increased in both groups over time, but the difference in risk of a major birth defect between ART children and spontaneously conceived children remained unchanged.…”

Section: Trends Over Timementioning

confidence: 99%

Perinatal outcome in children born after assisted reproductive technologies

Wennerholm

Bergh

2020

Upsala Journal of Medical Sciences

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Over the past 40 years access and effectiveness of assisted reproductive technologies (ART) have increased, and to date more than 8 million children have been conceived after ART globally. Most pregnancies resulting from ART are uncomplicated and result in the birth of healthy children. Yet, it is well known that pregnancies following ART are more likely to be affected by obstetric complications such as hypertensive disorders in pregnancy, preterm birth, and low birth weight compared with spontaneously conceived pregnancies. ART children are also at increased risk of birth defects. The majority of the problems arise as a result of multiple pregnancies and can be reduced by transferring a single embryo, thereby avoiding multiple pregnancies. New ART technologies are constantly introduced, and monitoring of the health of ART children is crucial.

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Trends over time in congenital malformations in live‐born children conceived after assisted reproductive technology

Abstract: When comparing children conceived after assisted reproductive technology and spontaneously conceived, the relative risk of being born with a major congenital malformation did not change during the study period.

Cited by 33 publications

References 30 publications

Effects of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional IVF cycles

Effects of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional IVF cycles

The health of children conceived by ART: ‘the chicken or the egg?’

Perinatal outcome in children born after assisted reproductive technologies

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