Trends of temporal bone cancer: SEER database

Acharya, Pankti P.; Sarma, Deeksha; McKinnon, Brian J.

doi:10.1016/j.amjoto.2019.102297

Cited by 12 publications

(20 citation statements)

References 15 publications

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“… 4 , 5 , 6 As a result, there is few uniform cancer staging standard for MESCC, and clinical practitioners usually have to solely rely on the tumor status (T‐classification) to guide the selection of management strategies and predict patients’ outcomes. Since a reliable cancer staging system is able to distinguish patients with different prognoses and guide the selection of management strategies before treatment starts, 7 , 8 , 9 researchers focusing on the staging system of MESCC have never ceased their steps.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the prognostic contributions of TNM classifications and building novel staging schemes for middle ear squamous cell carcinoma

et al. 2021

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Background A universally acknowledged cancer staging system considering all aspects of the T‐, N‐, and M‐classifications for middle ear squamous cell carcinoma (MESCC) remains absent, limiting the clinical management of MESCC patients. Materials and Methods A total of 214 MESCC patients were extracted from the SEER (the Surveillance, Epidemiology, and End Results) database between 1973 and 2016. The relationships between patient’s characteristics and prognoses were analyzed by Kaplan–Meier and Cox proportional hazards regression models. Novel staging schemes for MESCC were designed by adjusted hazard ratio (AHR) modeling method according to the combinations of Stell’s T‐classification and the eighth AJCC N‐ and M‐classifications, of which performances were evaluated based on five criteria: hazard consistency, hazard discrimination, explained variation, likelihood difference, and balance. Results T‐classification was the most significant prognostic factor for MESCC patients in multivariable analysis (p = 0.021). The N‐ and M‐classifications also had obvious prognostic effect but were not statistically significant by multivariate analysis due to the limited metastasis events. Three novel staging schemes (AHR‐Ⅰ–Ⅲ models, different combination of T‐ and N‐classifications) and ST (solely derived from Stell’s T‐classification) were developed, among which the AHR‐Ⅰ staging scheme performed best. Conclusions Tumor extension, quantified by Stell’s T‐classification, is the most significant prognostic factor for MESCC patients. However, our AHR‐Ⅰ staging scheme, a comprehensive staging scheme that integrating T‐, N‐, and M‐classifications, might be an optimal option for clinical practitioners to predict MESCC patients’ prognosis and make proper clinical decisions.

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Section: Introductionmentioning

confidence: 99%

Evaluating the prognostic contributions of TNM classifications and building novel staging schemes for middle ear squamous cell carcinoma

et al. 2021

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“…Primary carcinoma of the external auditory canal (EAC) is a rare disease with an estimated incidence of 1 to 5 cases per million people per year 1‐3 . Among these tumors, squamous cell carcinoma (SCC) is the most common histologic type 1,2,4 . EAC SCC can be extensively invasive to the temporal bone, where critical anatomical structures are located.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the modified Pittsburgh classification for predicting the disease‐free survival outcome of squamous cell carcinoma of the external auditory canal

et al. 2020

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“…[2][3][4][5][6] Surgical resection with or without adjuvant radiotherapy is the main strategy for EACSCC. [1][2][3][4][5] Although the prognosis for patients has been improved by advances in surgery and multidrug chemoradiotherapy, it is still poor in the advanced stages. 2,[5][6][7][8] The epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine kinases and is activated following its binding with peptide growth factors of the EGF family.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the epidermal growth factor receptor/phosphoinositide‐dependent protein kinase‐1 axis in tumor of the external auditory canal in response to epidermal growth factor stimulation

Akiyama

Yamamoto‐Fukuda

Yoshikawa

et al. 2022

Laryngoscope Investig Oto

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Objectives The epidermal growth factor receptor (EGFR) is related to the invasion and metastasis of external auditory canal (EAC) squamous cell carcinoma (SCC). The phosphoinositide‐dependent protein kinase‐1 (PDPK1) accelerates tumor cell growth through anti‐apoptotic signaling under the influence of downstream EGFR‐mediated signaling pathways. In this study, we investigated the EGFR/PDPK1 axis in the EAC under EGF stimulation. Methods We confirmed EGFR and PDPK1 expression in human EACSCC specimens immunohistochemically. We next transfected the EGF expression vector in the mouse EAC and then conducted a PDPK1 inhibitory experiment. Immunohistochemical analysis was performed in the mouse EAC, using anti‐EGF, anti‐EGFR, anti‐PDPK1, and anti‐Ki67 antibodies. Immunohistochemical analysis of cleaved caspase‐3 and terminal deoxy(d)‐UTP nick end labeling (TUNEL) detection assays were also performed for the assessment of apoptosis in the inhibitory experiment. Results Immunohistochemical analysis revealed overexpression and colocalization of EGFR and PDPK1 in human EACSCC specimens. The growth of a protuberant tumor was observed in the mouse EAC in which EGF expression vector was transfected, and EGF, EGFR, PDPK1, and Ki67 labeling indexes (LIs) were significantly increased. PDPK1 inhibition then induced normal epithelial appearance in the EAC. Moreover, EGF, EGFR, PDPK1, and Ki67 LIs were decreased, and cleaved caspase‐3 and TUNEL LIs were increased in the EAC. Conclusion We demonstrated the possibility that PDPK1 plays an important role in EACSCC. Level of Evidence: NA.

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Trends of temporal bone cancer: SEER database

Cited by 12 publications

References 15 publications

Evaluating the prognostic contributions of TNM classifications and building novel staging schemes for middle ear squamous cell carcinoma

Evaluating the prognostic contributions of TNM classifications and building novel staging schemes for middle ear squamous cell carcinoma

Evaluation of the modified Pittsburgh classification for predicting the disease‐free survival outcome of squamous cell carcinoma of the external auditory canal

Analysis of the epidermal growth factor receptor/phosphoinositide‐dependent protein kinase‐1 axis in tumor of the external auditory canal in response to epidermal growth factor stimulation

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