Trends of Gynecological Cancers in Turkey: Toward Europe or Asia?

Gültekin, Murat; Küçükyıldız, İrem; Karaca, Mujdegul Zayifoglu; Dundar, Selin; Boztaş, Güledal; Turan, Semra Hatice; Hacıkamiloglu, Ezgi; Keskinkılıç, Bekir

doi:10.1136/ijgc-00009577-201710001-00001

Cited by 7 publications

(4 citation statements)

References 9 publications

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“…The peak frequency of age at diagnosis in this study was significantly associated with age showing higher diagnoses among patients over 60 years of age representing 50.2% study population. Similar results were yielded from different studies showing the peak frequency among post-menopausal women which can be explained by the change of hormones in post-menopausal age [ 5 , 6 ]. Family planning was introduced in 1961 with contraceptive pills and condoms initially being used in 1970 and obtained full coverage in 1985 impacting the parity rate and increase of hormonal replacement therapy [ 6 ].…”

Section: Discussionsupporting

confidence: 87%

“…It is important to note that the exponential increase in the frequency reported could also be due to the limited data resources available in the earlier years. Likewise, a study that analysed the frequency of uterine cancer in Thailand projected the incidence to rise from 1.5 to 5.3 per 100,000 women years in 2016 to 8 per 100,000 women years in 2030 [ 5 ]. The study attributed the rise in uterine malignancy to increased body mass index (BMI) ≥25 kg/m 2 , diabetes mellitus, and hypertension.…”

Section: Discussionmentioning

confidence: 99%

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Uterine Malignancy: Pathological Pattern and Changing Incidence in a Teaching Hospital in Jeddah, Saudi Arabia

Turkistani¹,

Abdullah²

2023

Cureus

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Introduction: Uterine carcinoma is one of the most common malignancies affecting women globally. It is the second most common gynecologic malignancy in impoverished countries and the most common in industrialized countries. Objective: To describe the histopathological patterns of uterine malignancies and their changing incidence at King Abdulaziz University Hospital from 2011 to 2020. Methodology: A retrospective study was conducted to analyze female patient record files from 2011 to 2020 who underwent uterine resection surgery at the King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Results: A total of 263 patients were included. The age ranged from 30 to 95 years old; median age of 61 years. The majority (71%) presented with the complaint of abnormal uterine bleeding. The most common histopathological diagnosis was endometrioid carcinoma (70%), followed by serous carcinoma (13.7%). The lowest reported uterine cancer diagnoses were in the year of 2011 with (<5%) of the cases while the highest were in the year of 2020. These findings demonstrate a variable incidence of endometrial carcinomas in the study population over the study period. With trends of an increasing incidence till 2018 followed by a marginal reduction in 2019 and 2020. Conclusion: The most frequent histopathological diagnosis of uterine cancer was endometrioid carcinoma followed by serous carcinoma, (70%) and (13.7%) respectively. Type 1 endometrial carcinoma was prevalent throughout the decade surpassing the type-2 endometrial carcinoma. The trend also shows a steady increase in the frequency of uterine cancer which is alarming and prompts further research to determine factors associated with and molecular classification of reported uterine cancer cases.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Uterine Malignancy: Pathological Pattern and Changing Incidence in a Teaching Hospital in Jeddah, Saudi Arabia

Turkistani¹,

Abdullah²

2023

Cureus

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“…Histopatolojik analiz yapıldığı zaman serviks kökenli yapılan egzenterasyonların %33'ünün adenokanser nedenli yapıldığı anlaşılmaktadır. Türkiye de primer serviks kanseri tanılarının %19 unu servikal adenokanserler oluşturmak ile beraber bizim çalışmamızda adenokanser insidansı (%33) yaklaşık 1.5 kat fazla gelmiştir (10). Bunun sebebi servikal adenokanser'in prognozunun servikal skuamöz hücreli kansere göre daha kötü seyretmesi olabilir.…”

Section: Discussionunclassified

Ji̇nekoloji̇k Kanserler Ve Pelvi̇k Egzenterasyon Kisa Dönem Sonuçlari Tek Merkez Deneyi̇mleri̇

Sözen

Tosun

Engin

et al. 2018

Zeynep Kamil Tıp Bülteni

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Pelvik egzenterasyon rekürren jinekolojik kanserlerde kür veya daha uzun sağkalım amacıyla uygulanan ultraradikal bir cerrahidir. Bu çalışmanın birincil amacı kliniğimizce pelvik egzenterasyon operasyonu uygulanan hastaların klinik özelliklerini, operatif ve postoperatif komplikasyon türlerini ve sıklığını tanımlamaktır. Kısa dönem ortalama sağkalım ve hastalıksız sağkalım rakamlarını belirlemek çalışmanın ikincil amacıdır.

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“…Endometrial cancer (EC) is the second most frequently encountered gynecological cancer worldwide, and endometrioid endometrial carcinoma (EEC) represents approximately 75-80% of patients with EC [1][2][3]. EC is categorized as low, intermediate, and high risk according to the stage, tumor grade, and histological subtype [4].…”

Section: Introductionmentioning

confidence: 99%

The impact of Ki-67 index, squamous differentiation and several clinicopathologic parameters on the recurrence of low and intermediate-risk endometrial cancer

Ocak

Atalay

Şahin

et al. 2021

Bosn J of Basic Med Sci

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Endometrial endometrioid carcinoma (EEC) represents approximately 75–80% of endometrial carcinoma cases. Three hundred thirty-six patients with EEC followed-up in the authors’ medical center between and 2010–2018 were included in our study. Two hundred seventy-two low- and intermediate- EEC patients were identified using the European Society for Medical Oncology criteria and confirmed by histopathological examination. Recurrence was reported in 17 of these patients. The study group consisted of patients with relapse. A control group of 51 patients was formed at a ratio of 3:1 according to age, stage, and grade, similar to that in the study group. Of the 17 patients with recurrent disease, 13 patients (76.5%) were stage 1A, and 4 patients (23.5%) were stage 1B. No significant difference was found in age, stage, and grade between the case and control groups (p>0.05). Body mass index, parity, tumor size, lower uterine segment involvement, SqD, and Ki-67 index with p<0.25 in the univariate logistic regression analysis were included in the multivariate analysis. Ki-67 was statistically significant in multivariate analysis (p=0.018); however, there was no statistical significance in SqD and other parameters. Our data suggest that the Ki-67 index rather than SqD needs to be assessed for recurrence in patients with low- and intermediate-risk EEC.

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Trends of Gynecological Cancers in Turkey: Toward Europe or Asia?

Cited by 7 publications

References 9 publications

Uterine Malignancy: Pathological Pattern and Changing Incidence in a Teaching Hospital in Jeddah, Saudi Arabia

Uterine Malignancy: Pathological Pattern and Changing Incidence in a Teaching Hospital in Jeddah, Saudi Arabia

Ji̇nekoloji̇k Kanserler Ve Pelvi̇k Egzenterasyon Kisa Dönem Sonuçlari Tek Merkez Deneyi̇mleri̇

The impact of Ki-67 index, squamous differentiation and several clinicopathologic parameters on the recurrence of low and intermediate-risk endometrial cancer

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