Trends in the Research Into Immune Checkpoint Blockade by Anti-PD1/PDL1 Antibodies in Cancer Immunotherapy: A Bibliometric Study

Sun, Yiting; Jiang, Liqing; Wen, Ti; Guo, Xiaoyu; Shao, Xinye; Qü, Hui; Chen, Xi; Song, Yujia; Wang, Fang; Qu, Xiujuan; Li, Zhi

doi:10.3389/fphar.2021.670900

Cited by 9 publications

(8 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the last decade, immune checkpoint inhibitors (ICIs) had shown considerable anti-tumor efficacy and drastically changed treatment paradigms for patients with advanced-stage, unresectable, or mUC (9)(10)(11)(12). The programmed death receptor 1 (PD-1) and its ligand programmed death receptor ligand 1 (PD-L1) are the most w i d e l y s t u d i e d i m m u n e c h e c k p o i n t s f o r c a n c e r immunotherapy (13,14). In recent years, the US Food and Drug Administration (FDA) has approved five PD-1/PD-L1 inhibitors for treating patients with advanced UC: atezolizumab, pembrolizumab, nivolumab, durvalumab, and avelumab (15).…”

Section: Introductionmentioning

confidence: 99%

The global research of bladder cancer immunotherapy from 2012 to 2021: A bibliometric analysis

Qiu

Deng²,

Li³

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

Intravesical instillation of Bacillus Calmette-Guérin has been used as an immunotherapy to treat superficial bladder cancer for almost half a century. In recent years, the approval of several monoclonal antibody treatments has transformed the treatment landscape for patients with muscle-invasive or metastatic uroepithelial carcinoma. The purpose of this study was to conduct a thorough review of immunotherapy in bladder cancer through a bibliometric approach. Publications related to bladder cancer immunotherapy were obtained from the Web of Science Core Collection on July 1st, 2022. We conducted a bibliometric analysis of literature information using CiteSpace IV, VOSviewer, and Scimago Graphica, including co-authorship or co-citation of authors, countries/regions, journals, references, and keyword co-occurrence. There was a total of 2,352 papers included, with the most contributions coming from the United States, China, and Italy. The United States had the highest H-index value and was the leading country in this field. Meanwhile, the number of publications in China was steadily growing. The top three productive researchers were Kamat AM, Necchi A, and Shariat SF, with Powles T as the top co-cited author. Most papers were published by the University of Texas System. The majority of papers in this field were published in Urologic Oncology Seminars and Original Investigations and European Urology was the most influential journal with the highest H-index. The tumor microenvironment and complete molecular characterization may still be the frontier in this research area, allowing us to obtain a better understanding of the pathogenesis and clinical prognosis of bladder cancer. More research are conducted to identify clinically meaningful biomarkers that may provide opportunities for the personalization of bladder cancer therapy. This study provides clinicians and researchers with an overview and helpful guidance on how to choose the research direction and management of bladder cancer immunotherapy.

show abstract

Section: Introductionmentioning

confidence: 99%

The global research of bladder cancer immunotherapy from 2012 to 2021: A bibliometric analysis

Qiu

Deng²,

Li³

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…Furthermore, they described the high outbreak article and its research content. The difference is that the authors divided the retrieved articles into three parts: article, mata analysis, and RCT to perform a study ( 74 ). Nevertheless, our research is more comprehensive (over 10,000 articles with articles and reviews included).…”

Section: Discussionmentioning

confidence: 99%

Immunotherapy improves disease prognosis by affecting the tumor microenvironment: A bibliometric study

Deng

Zhao

2022

Front. Immunol.

View full text Add to dashboard Cite

BackgroundImmunotherapy has shown great potential for the treatment of multiple cancer and has been proven to be closely related to the tumor microenvironment. This article reveals collaborations and interactions among authors, nations, organizations, and periodicals assesses the knowledge base, and discovers hot tendencies and new topics associated with immunotherapy-tumor microenvironment (TME) research.MethodsThis article utilized bibliometrics and visual methods to provide a comprehensive overview of immunotherapy-TME research. Our team retrieved the WoSCC for research and reviews associated with immunotherapy and the tumor microenvironment. VOSviewer and Citespace were primarily used for literature measurement and knowledge graph analysis.ResultAll English articles and reviews on cancer immunotherapy effectiveness were collected, and 1,419 academic journals with 53,773 authors from 7,008 institutions in 92 countries/regions were found. Publications associated with immunotherapy-TME research were stably increasing. Frontiers of Immunology (n = 722) published the most papers on immunotherapy-TME, and Cancer Research (n = 6761) was the top co-cited journal. The published journals and co-cited journals focused on cancer and immunology fields. The League of European Research Universities (n = 978), Harvard University (n = 528), and the University of Texas system (n = 520) were the most productive institutions. Yang Liu (n = 34) and Topalian (n = 1978) ranked first among the top 10 scholars and co-cited scholars. Simultaneously, immunotherapy-TME researchers were involved in active collaborations. Elements of TME, the foundation of immunotherapy, and the application of immunotherapy in cancers represented the three principal aspects of immunotherapy-TME research. The latest hot spots are drug resistance, prognosis prediction, efficacy prediction, and m6A. Nanomedicine and m6A may be future hot topics. Future research in immunotherapy-TME may be directed at discovering how m6A modification affects tumor development by altering the tumor microenvironment and exploring how to enhance response or reduce drug resistance to immunotherapy by reversing or mediating the physicochemical properties of the TME.ConclusionsM6A and nanomedicine are also emerging hotspots in time zone diagrams with high centrality, and prognosis prediction using bioinformatics based on the development of prediction technology may be another future research hotspot.

show abstract

“…Take the field of oncology as an example, numerous previous studies have analyzed the publication trend and research hotspots of various types of tumors though bibliometric approaches ( Ahn and Hwang, 2020 ; Gu et al, 2021 ; Shi et al, 2021 ). In recent years, along with the development of various interventional techniques for malignant tumors such as chimeric antigen receptor (CAR)-based immunotherapy ( Pouliliou et al, 2020 ; Ou et al, 2022 ), programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) inhibitors treatment ( Sun et al, 2021 ; Liu et al, 2021 ); molecular targeted therapy ( Sheahan et al, 2018 ), monoclonal antibodies ( Kho and Brouwers, 2012 ), etc . many scholars have also conducted bibliometric studies to make a comprehensive analysis of these novel therapeutic strategies.…”

Section: Introductionmentioning

confidence: 99%

Bibliometric Analysis of Global Research on Cancer Photodynamic Therapy: Focus on Nano-Related Research

et al. 2022

View full text Add to dashboard Cite

A growing body of research has illuminated that photodynamic therapy (PDT) serves as an important therapeutic strategy in oncology and has become a hot topic in recent years. Although numerous papers related to cancer PDT (CPDT) have been published, no bibliometric studies have been conducted to summarize the research landscape, and highlight the research trends and hotspots in this field. This study collected 5,804 records on CPDT published between 2000 and 2021 from Web of Science Core Collection. Bibliometric analysis and visualization were conducted using VOSviewer, CiteSpace, and one online platform. The annual publication and citation results revealed significant increasing trends over the past 22 years. China and the United States, contributing 56.24% of the total publications, were the main driving force in this field. Chinese Academy of Sciences was the most prolific institution. Photodiagnosis and Photodynamic Therapy and Photochemistry and Photobiology were the most productive and most co-cited journals, respectively. All keywords were categorized into four clusters including studies on nanomaterial technology, clinical applications, mechanism, and photosensitizers. “nanotech-based PDT” and “enhanced PDT” were current research hotspots. In addition to several nano-related topics such as “nanosphere,” “nanoparticle,” “nanomaterial,” “nanoplatform,” “nanomedicine” and “gold nanoparticle,” the following topics including “photothermal therapy,” “metal organic framework,” “checkpoint blockade,” “tumor microenvironment,” “prodrug” also deserve further attention in the near future.

show abstract

Trends in the Research Into Immune Checkpoint Blockade by Anti-PD1/PDL1 Antibodies in Cancer Immunotherapy: A Bibliometric Study

Cited by 9 publications

References 97 publications

The global research of bladder cancer immunotherapy from 2012 to 2021: A bibliometric analysis

The global research of bladder cancer immunotherapy from 2012 to 2021: A bibliometric analysis

Immunotherapy improves disease prognosis by affecting the tumor microenvironment: A bibliometric study

Bibliometric Analysis of Global Research on Cancer Photodynamic Therapy: Focus on Nano-Related Research

Contact Info

Product

Resources

About