Immunotherapy improves disease prognosis by affecting the tumor microenvironment: A bibliometric study

Abstract

BackgroundImmunotherapy has shown great potential for the treatment of multiple cancer and has been proven to be closely related to the tumor microenvironment. This article reveals collaborations and interactions among authors, nations, organizations, and periodicals assesses the knowledge base, and discovers hot tendencies and new topics associated with immunotherapy-tumor microenvironment (TME) research.MethodsThis article utilized bibliometrics and visual methods to provide a comprehensive overview of immunotherapy-TME research. Our team retrieved the WoSCC for research and reviews associated with immunotherapy and the tumor microenvironment. VOSviewer and Citespace were primarily used for literature measurement and knowledge graph analysis.ResultAll English articles and reviews on cancer immunotherapy effectiveness were collected, and 1,419 academic journals with 53,773 authors from 7,008 institutions in 92 countries/regions were found. Publications associated with immunotherapy-TME research were stably increasing. Frontiers of Immunology (n = 722) published the most papers on immunotherapy-TME, and Cancer Research (n = 6761) was the top co-cited journal. The published journals and co-cited journals focused on cancer and immunology fields. The League of European Research Universities (n = 978), Harvard University (n = 528), and the University of Texas system (n = 520) were the most productive institutions. Yang Liu (n = 34) and Topalian (n = 1978) ranked first among the top 10 scholars and co-cited scholars. Simultaneously, immunotherapy-TME researchers were involved in active collaborations. Elements of TME, the foundation of immunotherapy, and the application of immunotherapy in cancers represented the three principal aspects of immunotherapy-TME research. The latest hot spots are drug resistance, prognosis prediction, efficacy prediction, and m6A. Nanomedicine and m6A may be future hot topics. Future research in immunotherapy-TME may be directed at discovering how m6A modification affects tumor development by altering the tumor microenvironment and exploring how to enhance response or reduce drug resistance to immunotherapy by reversing or mediating the physicochemical properties of the TME.ConclusionsM6A and nanomedicine are also emerging hotspots in time zone diagrams with high centrality, and prognosis prediction using bioinformatics based on the development of prediction technology may be another future research hotspot.

Bi-level Graph Learning Unveils Prognosis-Relevant Tumor Microenvironment Patterns from Breast Multiplexed Digital Pathology

“…The TME represents a fundamental piece in the study of cancer biology, and several recent studies indicate its promise for discovering biomarkers for prognosis and even treatment resistance [3,4,19,20,[53][54][55]. However, the number of broadly applicable biomarkers from pathology that provide strong prognosis information, while generalizing to different studies, remains limited.…”

“…The tumor microenvironment (TME) is a complex ecosystem, comprising proliferating tumor cells, tumor stroma, immune cells, blood and lymphatic vessels [1]. There is accumulating evidence underscoring the pivotal role of the TME in driving tumor progression [2], contributing to treatment resistance 1 [3], and influencing patient prognosis [4]. Recent technological advancements in spatial multiplex proteomics, such as multiplexed immunohistochemistry (mIHC) [5], co-detection by indexing (CODEX) [6], multiplexed ion beam imaging (MIBI) [7], and imaging mass cytometry (IMC) [8], have enabled the simultaneous assessment of a wide spectrum of proteins in tissue specimens.…”

Frontiers and hotspots in hand, foot, and mouth disease research during 2006 to 2023: A bibliometric and visual analysis

“…The parameters in VOSviewer were set as follows: select “association strength” as the standardization method, and set the thresholds as at least 5 publications in countries/regions, at least 30 publications in institutions, at least 20 publications by author, publications, or co-citations by journal, at least 50 co-occurring keywords, and at least 100 citations in each publication. [ 9 , 10 ] The data exported from the VOSviewer analysis were imported into Charticulator ( https://donghaoren.org/charticulator/index.html ) and SCImago Graphica to optimize the visual outputs while maintaining their original contextual meanings. Charticulator was used to enhance author co-occurrence networks and journal co-occurrence networks, while SCImago Graphica perfected countries’ analysis and keyword co-occurrence analysis.…”

Knowledge mapping of therapeutic cancer vaccine from 2013 to 2022: A bibliometric and visual analysis

“…Bibliometric data were obtained from the Web of Science Core Collection (WOSCC) database, which is widely used for bibliometric analyses and offers comprehensive bibliometric information. 19 , 20 A search was conducted in the WOSCC database on March 30, 2023, covering the period from 2013 to 2022. The search strategy outlined in Figure 1 was used.…”