Trends in the prescribing pattern of spironolactone for acne and hidradenitis suppurativa in adolescents

Horissian, Mikael; Maczuga, Steve; Barbieri, John S.; Zaenglein, Andrea L.

doi:10.1016/j.jaad.2021.12.005

Cited by 5 publications

(2 citation statements)

References 8 publications

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Section: Resultsmentioning

confidence: 99%

“…In recent years, use of spironolactone in young female patients has increased significantly [ 32 ]. In the age group of 13 to 19 years, its usage has increased three times compared to previous years [ 32 , 33 ]. Spironolactone is a competitive aldosterone receptor antagonist and has weak antiandrogenic, estrogenic, and glucocorticoid effects.…”

Section: Resultsmentioning

confidence: 99%

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The Role of Hormones in Hidradenitis Suppurativa: A Systematic Review

Rached

Gambichler

Dietrich

et al. 2022

IJMS

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Hidradenitis suppurativa (HS) is a chronic inflammatory disease manifesting in inverse body regions. In a systematic review, the role of hormones in HS will be presented to better understand the pathomechanisms of HS. The review is based on the PRISMA criteria. Systematic research was carried out using keywords. Subsequently, the data were analyzed based on the clinical response and other relevant information. The main focus of our systematic review was on HS manifestation, exacerbation, sex hormones, antiandrogen therapy, thyroid function, polycystic ovary syndrome, insulin resistance, and adipokines. In HS, there appears to be a dysregulated adipokine release that is shifted towards pro-inflammatory adipokines. Insulin resistance is significantly more common in HS than in healthy patients regardless of BMI, age, and gender. Insulin resistance in HS patients leads to further cardiovascular disease. The mechanism of insulin resistance and role of adipokines should be investigated in future studies to better provide the pathomechanisms of HS. The role of androgens seems to be important in a certain subgroup of female patients. Anti-androgenic therapy can be useful and helpful in some patients. However, further studies are needed to better understand the hormonal relationship in HS.

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Section: Resultsmentioning

confidence: 99%