Trends in the epidemiology of inflammatory bowel disease in Colombia by demographics and region using a nationally representative claims database and characterization of inflammatory bowel disease phenotype in a case series of Colombian patients

Baños, Fabián Juliao; Kock, Joshua; Arrubla, Mateo; Calixto, Omar-Javier; Camargo, Joselyn; Cruz, Lina; Hurtado, Juan J Delgado; Clavijo, Absalón; Donado, Jorge; Schwartz, Seth J.; Abreu, María T.; Damas, Oriana M.

doi:10.1097/md.0000000000024729

Cited by 26 publications

(15 citation statements)

References 35 publications

(13 reference statements)

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“…[11] Subsequently, the frequency of CD increased from 47.1% to 52.9% for UC. [12,13,24,25] In the Dominican Republic, CD predominated at 61.0%; in Peru, CD had a frequency of 53.1%, which increased from a previously published study that showed a frequency of 23% for CD and 77% for UC. [26] UC was predominant in Venezuela (78.2%), Cuba (69.9%), and Mexico (78.6%).…”

Section: Discussionmentioning

confidence: 93%

“…[ 11 ] In Colombia, from 2001 to 2009, 80.7% had UC, and 15.8% had CD. [ 12 ] The incidence of UC reported in Panama was 1.2/100,000 per year, with no reported cases of CD, and in Argentina 2.2/100,000 per year, with only one case identified with CD. [ 13 ] In Chile, the estimated prevalence has not been determined, but a descriptive study reported that approximately 71% of IBD cases have UC and 27% have CD.…”

Section: Introductionmentioning

confidence: 99%

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Clinical differentiation of inflammatory bowel disease (IBD) in Latin America and the Caribbean

Yamamoto‐Furusho¹,

Parra-Holguín²,

Baños

et al. 2022

Medicine

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The aim of the present study was to describe the epidemiological and clinical characteristics of inflammatory bowel disease (IBD), including medical and surgical treatments, in several countries in Latin America and the Caribbean. IBD is recognized as a global health problem because its incidence and prevalence have increased significantly over the last few years. This multicenter retrospective cohort study included 4714 patients with IBD diagnosed from 9 countries in Latin America and the Caribbean: Colombia, Cuba, Dominican Republic, Ecuador, Mexico, Peru, Puerto Rico, Uruguay, and Venezuela. Crohn disease (CD) was more frequent in Puerto Rico (71.9%), the Dominican Republic (61.0%), and Peru (53.1%). Ulcerative colitis was more frequent in Colombia (78.6%), Venezuela (78.2%), Mexico (75.5%), Cuba (69.9%), Ecuador (64.1%), and Uruguay (60.9%). The following clinical characteristics were more frequent in the Caribbean: penetrating behavior in CD, steroid dependence, steroid resistance, intolerance to thiopurines, extraintestinal manifestations, surgeries, hospitalizations due to IBD, and family history of IBD. The factors associated with the use of biological therapy were pancolitis in ulcerative colitis, penetrating behavior in CD, steroid resistance and dependence, presence of extraintestinal manifestations, and the need for surgery. This study from Latin America and the Caribbean demonstrated the different epidemiological and clinical characteristics of IBD.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Clinical differentiation of inflammatory bowel disease (IBD) in Latin America and the Caribbean

Yamamoto‐Furusho¹,

Parra-Holguín²,

Baños

et al. 2022

Medicine

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“…UC is a global disease that threatens the lives of people worldwide. 28 To slow the progression of the disease, doctors recommend a variety of treatments, including antibiotics, immunosuppressive drugs, and corticosteroids. However, there are concerns about their potential side effects.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effects ofAralia elataExtract Against Dextran Sodium Sulfate-Induced Colitis in Mice and Raw 264.7 Macrophage Cells Exposed to Lipopolysaccharide: First Report

Lee

Adam

et al. 2022

Natural Product Communications

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Aralia elata (AE) is an anti-inflammatory, polyphenolic containing medicinal plant. However, little is known about AE and its application to ulcerative colitis (UC). This study aimed to confirm AE extract's antioxidant and anti-inflammatory effects in vivo and in vitro. The in vitro antioxidant activity was evaluated by measuring total polyphenol and flavonoid content in AE extract. AE extract (10 000 mg/L) contained 186.8 mg GAE/g polyphenol and 81.9 mg QE/g flavonoid. Mice were divided into 6 groups, including control, which received normal saline, and treatment groups, which received dextran sodium sulfate (DSS) with or without AE extract (250, 500, and 1000 mg/kg). RAW 264.7 macrophage cells were divided into 2 groups: control and treatment. RAW 264.7 macrophage cells treated with sterile double distilled water, 1 mg/L lipopolysaccharide (LPS), and AE extracts (25, 50, 75, 100 µg/mL) were used to assess the cytotoxicity and anti-inflammatory activity. High-performance liquid chromatography, enzyme-linked immunosorbent assay (ELISA) kits, and histology were employed to analyze the AE extract contents, nitric oxide (NO), tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6, as oxidative stress markers. In addition, the disease activity index (DAI) and cytotoxicity were determined in mice and cells, respectively. High-performance liquid chromatography analysis revealed that AE extract is rich in chlorogenic acid (96 ± 0.01 mg/g). DSS increased the DAI and levels of TNF-α, IL-1β, and immune cell infiltration compared with those of the control animals. Furthermore, LPS eventually reduced cell viability and increased the levels of NO, TNF-α, IL-1β, and IL-6 in contrast to control cells. After treatment, a noticeable reduction was observed in the levels of DAI, NO, TNF-α, IL-1β, and IL-6 compared to those without AE treatments. Overall, AE extract is safe and had anti-inflammatory properties. Therefore, AE extract can be considered a potential pre-treatment supplement for UC.

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“…Thus, the incidence rate of CD with age increases sharply and reaches its maximum values. Trends in the incidence of CD in various studied groups of the population make it possible to assess and characterize the general trend of growth or decline in indicators in different regions of the world [10]. Therefore, in Kazakhstan, the incidence rate for the research years in the studied groups had a pronounced tendency to decrease.…”

Section: Health Organization Original Investigationsmentioning

confidence: 99%

Crohn's disease in Kazakhstan: epidemiological aspects of incidence

et al. 2021

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Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract with an increasing incidence worldwide and widespread in industrialized countries, while the incidence is also increasing in Asia and the Middle East. Purpose of the study. To study the epidemiological aspects of the incidence of CD in Kazakhstan. Material and methods. The study for 2013-2018, analyzed the registration and reporting forms of the Ministry of Health of the Republic of Kazakhstan on new cases of CD (ICD: K50) using descriptive and analytical methods of biomedical statistics. Results. During the study period, 4,671 new cases of CD were registered in Kazakhstan, of which 341 (7.9%) in children under 15 years old, 84 (2.0%) in adolescents (15-17 years old) and adults (18 years old and older) – 4,226 cases (90.9%). The incidence of CD in Kazakhstan was 4.5 per 100,000 of the total population, while in children – 1.210/0000 (95% CI=1.09-1.32), in adolescents – 2.120/0000 (95% CI=1.47-2.77) and the adult population – 5.860/0000 (95% CI=3.20-8.53). The trends in the CD incidence as a whole in the entire population had a pronounced tendency to decrease (Тde=−30.3%), a slight increase was observed only in the child population (Тin=+1.1%), and in other studied groups they decreased: in adolescents – Тde=−11.9% and in the adult population – Тde=−33.8%. Conclusion. The study has revealed some aspects of incidence in different age groups and the established trends require further study of this pathology. Keywords: Crohn's disease, incidence, trends, Kazakhstan.

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Trends in the epidemiology of inflammatory bowel disease in Colombia by demographics and region using a nationally representative claims database and characterization of inflammatory bowel disease phenotype in a case series of Colombian patients

Cited by 26 publications

References 35 publications

Clinical differentiation of inflammatory bowel disease (IBD) in Latin America and the Caribbean

Clinical differentiation of inflammatory bowel disease (IBD) in Latin America and the Caribbean

Anti-Inflammatory Effects ofAralia elataExtract Against Dextran Sodium Sulfate-Induced Colitis in Mice and Raw 264.7 Macrophage Cells Exposed to Lipopolysaccharide: First Report

Crohn's disease in Kazakhstan: epidemiological aspects of incidence

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