Trends in the design of nerve guidance channels in peripheral nerve tissue engineering

Chiono, Valeria; Tonda‐Turo, Chiara

doi:10.1016/j.pneurobio.2015.06.001

Cited by 249 publications

(253 citation statements)

References 121 publications

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“…Scaffolds for nerve tissue engineering are typically either hollow or filled tubes designed to be biocompatible, degradable, and mechanically matched to nerves to support cells, growth factor release, or a combination of both [48]. In addition, variations in topography, conduit design, and functionalization have become increasingly popular modes of optimizing scaffold design [49]. Because of these design criteria, PLA and its composites have been utilized in the development of degradable nerve guidance conduits.…”

Section: Pla Scaffolds For Nervous Tissue Engineeringmentioning

confidence: 99%

Poly(lactic acid) nanofibrous scaffolds for tissue engineering

Santoro

Shah

Walker

et al. 2016

Advanced Drug Delivery Reviews

379

182

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Poly(lactic acid) (PLA) is a synthetic polyester that has shown extensive utility in tissue engineering. Synthesized either by ring opening polymerization or polycondensation, PLA hydrolytically degrades into lactic acid, a metabolic byproduct, making it suitable for medical applications. Specifically, PLA nanofibers have widened the possible uses of PLA scaffolds for regenerative medicine and drug delivery applications. The use of nanofibrous scaffolds imparts a host of desirable properties, including high surface area, biomimicry of native extracellular matrix architecture, and tuning of mechanical properties, all of which are important facets of designing scaffolds for a particular organ system. Additionally, nanofibrous PLA scaffolds hold great promise as drug delivery carriers, where fabrication parameters and drug-PLA compatibility greatly affect the drug release kinetics. In this review, we present the latest advances in the use of PLA nanofibrous scaffolds for musculoskeletal, nervous, cardiovascular, and cutaneous tissue engineering and offer perspectives on their future use.

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Section: Pla Scaffolds For Nervous Tissue Engineeringmentioning

confidence: 99%

Poly(lactic acid) nanofibrous scaffolds for tissue engineering

Santoro

Shah

Walker

et al. 2016

Advanced Drug Delivery Reviews

379

182

View full text Add to dashboard Cite

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“…The nerve guide can be represented by an autologous nerve segment (traditional autograft), e.g., from the sural nerve or by a non-nervous conduit [5,30]. Along the last years, an increasing number of papers describing innovative bio-artificial nerve guides has been published [7]. In general, nerve guides are composed of two main components: a tubular scaffold which can be sutured (or glued) to the nerve stumps and a luminal filler which provides the substrate for cell migration and axon regeneration inside the conduit.…”

Section: Discussionmentioning

confidence: 99%

“…To prevent this occurrence, a luminal filler must be used for providing a substrate for early nerve fiber regeneration [5][6][7]. A number of different materials have been investigated as luminal fillers for nerve guides, including biological or artificial substrates [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Peripheral Nerve Reconstruction Using Enriched Chitosan Conduits

Rochkind¹,

Mandelbaum-Livnat²,

StefaniaRaimondo³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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The repair of peripheral nerve traumatic lesions still represents a major cause of permanent motor and sensory impairment. In case of substance loss, a nerve guide should be used to bridge the proximal with the distal stump of the severed nerve. The effectiveness of hollow nerve guides is limited by the delay of axonal growth due to the absence of a regeneration substrate inside the conduit. To fasten up nerve regeneration, nerve guides should thus be enriched by a luminal filler. In this study, we investigated, in a 12-mm rat sciatic nerve defect experimental model, the effectiveness of chitosan-based conduits of different acetylation filled either with a hyaluronic acid gel (NVR gel) or with a magnetic fibrin hydrogel, in comparison with traditional autografts. Results showed that all types of artificial nerve conduits led to functional recovery not significantly different from autografts. By contrast, morphological and morphometrical analyses showed that the best results among nerve guides were found in medium degree of acetylation (DAII: ∼5%) chitosan conduits enriched with the NVR gel.

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“…Nowadays, the standard clinical procedures for treating PNIs, that are based on autogenic or allogenic grafting, are being replaced by biofunctionalized polymeric implants called nerve guidance conduits (NGCs) (Faroni et al, 2015). peripheral nerves (Gu et al, 2014;Chiono and Tonda-Turo, 2015). The recent findings show that an ideal implant for peripheral nerve tissue regeneration (PNTR) should both physically and biochemically resemble properties of a peripheral nerve extracellular matrix.…”

Section: Introductionmentioning

confidence: 99%

“…Despite a wide variety of off-the-shelf available NGCs, their use is still problematic. The main obstacles are the structural properties of implants that should be strictly tailored to mechanical requirements (i.e., ability to withstand the compression stress from the surrounding tissues and to bend without kinking), target degradation rate (i.e., degradation rate adjusted to the nerve regeneration rate), and permeability characteristics (i.e., appropriate pore sizes and porosity) (Chiono and Tonda-Turo, 2015). The length of the conduit should be sufficient to connect the nerve gap without generating tension.…”

Section: Introductionmentioning

confidence: 99%