Tubular electrodeposition of chitosan–carbon nanotube implants enriched with calcium ions

Nawrotek, Katarzyna; Tylman, Michał; Rudnicka, Karolina; Gatkowska, Justyna; Balcerzak, Jacek

doi:10.1016/j.jmbbm.2016.02.012

Cited by 33 publications

(23 citation statements)

References 26 publications

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“…These favorable changes induced by obtained implants support cellular homeostasis, their ability to adhere, and the maintenance of cellular communication. In addition, in our previous works, we showed that both chitosan and chitosan–carbon nanotube hydrogel implants give good tolerance when subjected to in vitro contact with L929 fibroblasts. Moreover, culturing fibroblasts in the milieu of those materials results in their higher proliferation than in nontreated cultures.…”

Section: Discussionmentioning

confidence: 79%

“…The manufacturing method of chitosan and chitosan–carbon nanotube hydrogel tubular implants, which was developed in our laboratory, is based on the electrodeposition phenomenon and was described earlier …”

Section: Methodsmentioning

confidence: 99%

“…Moreover, the inner diameter of the tubes can be easily regulated. In order to improve chemical as well as mechanical properties of conduits, carbon nanotubes were incorporated in their structure …”

Section: Introductionmentioning

confidence: 99%

“…In order to improve chemical as well as mechanical properties of conduits, carbon nanotubes were incorporated in their structure. 17 Taking into account the outcome of the abovementioned studies, the goal of the presented research was to assess in vitro biocompatibility on mHippoE-18 hippocampal cells, in vitro degradation, and in vivo tolerance of chitosan and chitosan-carbon nanotube hydrogel tubular implants. The MTT assay and confocal imaging report biological characterization of the developed structures.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of degradation and biocompatibility of electrodeposited chitosan and chitosan–carbon nanotube tubular implants

Nawrotek

Tylman

Decherchi

et al. 2016

J Biomedical Materials Res

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Designing three-dimensional tubular materials made of chitosan is still a challenging task. Availability of such forms is highly desired by tissue engineering, especially peripheral nerve tissue engineering. Aiming at this problem, we use an electrodeposition phenomenon in order to obtain chitosan and chitosan-carbon nanotube hydrogel tubular implants. The in vitro biocompatibility of the fabricated structures is assessed using a mouse hippocampal cell line (mHippoE-18). As both implants do not induce significant cytotoxicity, they are next subjected to in vitro degradation studies in the environment simulating in vivo conditions for specified periods of time: 7, 14, and 28 days. The mass loss of implants indicates their stability at the tested time period; therefore, the materials are subcutaneously implanted in Sprague Dawley rats. The explants are collected after 7, 14, and 28 days. The assessment of composition and changes in tissues surrounding the implanted materials is made in respect to surrounding tissue thickness as well as the number of blood vessels, macrophages, lymphocytes, and neutrophils. No symptoms of acute inflammation are noticed at any point in time. The observed regular healing process allows concluding that both chitosan and chitosan-carbon hydrogel tubular implants are biocompatible with high application potential in tissue engineering. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2701-2711, 2016.

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Section: Discussionmentioning

confidence: 79%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Assessment of degradation and biocompatibility of electrodeposited chitosan and chitosan–carbon nanotube tubular implants

Nawrotek

Tylman

Decherchi

et al. 2016

J Biomedical Materials Res

Self Cite

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show abstract

“…Also the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method has been frequently used to determine the cytotoxicity of chitosan composite materials. Several studies underline that CS/HAp do not induce cytotoxicity [21,22] and carry a low risk of biomaterial-induced inflammatory response [23]. In other case visible inflammatory reactions were reported for CS/HAP biomaterial, but blending the chitosan coating with poly-D,L-lactide-co-glycolide an increase in the quality of the newly formed bone tissue in the reconstructed defect area can be achieved [24].…”

Section: Introductionmentioning

confidence: 99%

Albumin adsorption study onto hydroxyapatite-multiwall carbon nanotube based composites

Czikó

Bogya

Paizs

et al. 2016

Materials Chemistry and Physics

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π‐Plasmon absorbance films of carboxylic functionalized CNTs coupled with renewable PGP platforms

Fares

2018

Polymers for Advanced Techs

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π‐Plasmon absorbance films of carboxylic functionalized multiwall carbon nanotubes (CNTs) coupled with renewable and recycled polycaprolactone grafted pectin (PGP) platforms as successful alternative for ordinary nondegradable platforms were investigated. Characterization of the synthesized carboxylic functionalized CNTs was performed using 1H NMR and attenuated total reflectance Fourier transform infrared for structural identification, thermogravimetric analysis and derivative thermogravimetric analysis for thermal stability, and X‐ray powder diffraction for crystal structure, whereas the characterization of prepared PGP was done by means of attenuated total reflectance Fourier transform infrared for chemical structure, differential scanning calorimetry for melting endotherms of polycaprolactone and high crystalline structure of PGP, and thermogravimetric analysis and derivative thermogravimetric analysis for thermal stability of PGP. Fabrication of water‐dispersed carboxylic functionalized CNTs coupled with PGP films was performed by casting technique in the presence of Ca2+ as cross‐linker. The thin films were tested for π‐plasmon absorbance using UV‐Vis spectrometry. Different fractions of carboxylic functionalized CNTs and PGP films demonstrated π‐plasmon absorbance broad peaks at λmax = 232 nm, which corresponded to 5.36 eV. The fabrication of novel films from renewable recycled PGP platform and advanced carboxylic functionalized CNTs properties will be the key features for many of next forthcoming technologies. The PGP considered as environment‐friendly and easily degradable platforms will be a successful alternative for conventional nondegradable electronic platforms, and water‐dispersed carboxylic functionalized CNTs with advanced properties will be finding accelerating executive applications.

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Tubular electrodeposition of chitosan–carbon nanotube implants enriched with calcium ions

Cited by 33 publications

References 26 publications

Assessment of degradation and biocompatibility of electrodeposited chitosan and chitosan–carbon nanotube tubular implants

Assessment of degradation and biocompatibility of electrodeposited chitosan and chitosan–carbon nanotube tubular implants

Albumin adsorption study onto hydroxyapatite-multiwall carbon nanotube based composites

π‐Plasmon absorbance films of carboxylic functionalized CNTs coupled with renewable PGP platforms

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