Trends in surgical and ablative treatment of localised renal cell carcinoma: A review of publication trends over 16 years (2000–2015)

Abstract

Objective: To investigate the bibliometric (publication) trends in surgical and ablative treatment of localised renal cell carcinoma (RCC) over a period of 16-years, from 2000 to 2015, as publication trends reflect clinical practice and new innovations. Material and methods: We performed a systematic review using PubMed over a 16-year period from 2000 to 2015 for all published papers on surgical and ablative management of renal tumours. Data were further analysed in two time periods, period-1 (2000-2007) and period-2 (2008-2015). Results: During the last 16 years a total of 2415 papers were published on surgical (n = 1662, 69%) and ablative (n = 753, 31%) management of RCC. This included partial nephrectomy (PN; n = 1662, 69%), cryoablation (CA; n = 405, 17%), and radiofrequency ablation (RFA; n = 348, 14%). When comparing the two time periods for PN, during period-2, the change was +189% (P < 0.001), +69% (P = 0.004) and +4600% (P < 0.001) for open PN, laparoscopic PN and robotic PN, respectively. Regarding ablative techniques, a change of +109% (P = 0.002) and +78% (P = 0.036) was seen for CA and RFA, respectively. There was also a significant rise in percutaneous CA when compared to laparoscopic CA (P < 0.002). Conclusions: There has been a rise in all forms of PN and ablative techniques over the last 16 years. This rise has been particularly steep for robotic PN potentially reflecting a change in surgical practice.

NVP-BEZ235 Inhibits Renal Cell Carcinoma by Targeting TAK1 and PI3K/Akt/mTOR Pathways

“…Renal cell carcinomas (RCC) is the most frequent type of cancer originating from the kidney parenchyma ( Inamura, 2017 ; Pietropaolo et al, 2019 ). Every year, approximately more than 200,000 individuals are newly diagnosed with RCC worldwide ( Bray et al, 2018 ).…”

Parallel comparison of R.E.N.A.L., PADUA, and C‐index scoring systems in predicting outcomes after partial nephrectomy: A systematic review and meta‐analysis

“…Thanks to the widespread application of radiological imaging (e.g., ultrasonography and computerized tomography), the cases of RCC could be more frequently detected. 2 Although there are various types of therapies for RCC of different stages, surgery is the only effective treatment for localized RCC. 3 Thus, radical nephrectomy (RN) and partial nephrectomy (PN) were established successively.…”

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“…popularity due to its favorable oncologic efficacy and complication profile. When comparing papers on PubMed from 2000 to 2007 versus 2008 to 2015 using systematic review per Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, Pietropaolo et al reported a change of +109% (P = 0.002) and +78% (P = 0.036) was seen for cryoablation (CA) and radiofrequency ablation (RFA), respectively [2]. Shi et al reported an increase in TA from 8.1% in 2004 to 14.9% in 2016 using the retrospective Surveillance, Epidemiology, and End Results (SEER)-Medicare associated databases [3].…”