Parallel comparison of R.E.N.A.L., PADUA, and C‐index scoring systems in predicting outcomes after partial nephrectomy: A systematic review and meta‐analysis

Sun, Jiale; Zhang, Zhiyu; Zhang, Haoyang; Zhou, Qi; Xu, Jiangnan; Ling, Zhixin; Ouyang, Jun

doi:10.1002/cam4.4047

Cited by 7 publications

(1 citation statement)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By contrast, the C-Index score is simple in parameters, but complex in calculation. More importantly, it regards the kidney as an approximate ellipsoid, ignoring the irregularity of tumor ( 24 ). The DAP score is a synthesis and simplification of R.E.N.A.L.…”

Section: Discussionmentioning

confidence: 99%

A morphology-based nephrometry score to predict pathological upstaging to T3 renal cell carcinoma

et al. 2022

View full text Add to dashboard Cite

Background: Patients with clinical T1-2 renal cell carcinoma (RCC) upstaging to pathological T3 showed worse survival prognosis than those without upstaging. We aimed to develop and validate a morphologybased nephrometry scoring system for predicting pathological upstaging to T3 of RCC. Methods:We retrospectively reviewed 200 patients with clinical T1-2 RCC who underwent surgical treatment. The nephrometry scores were measured through preoperative computed tomography images.The risk factors of pathological upstaging were identified by logistic regression models. The predictive accuracy of a novel morphology-based nephrometry scoring system (M-Index), was compared with R.E.N.A.L (radius, exophytic/endophytic, nearness, anterior/posterior, location), PADUA (preoperative aspects and dimensions used for an anatomic classification), DAP (diameter, axial, polar) and C-Index scores. Results:The upstaging rate of the population was 17% (34 out of 200 patients). The upstaging and non-upstaging groups were comparable in terms of age, gender ratio, body mass index, tumor laterality, and pathological type, while the upstaging group tended to have large tumor diameter, irregular tumor morphology, inner tumor location, and short polar and axial distance. Large tumor diameter refers to larger than 5 cm, while irregular tumor morphology refers to not regular shapes such as round, oval, or lobular. Univariate and multivariate logistic regression analyses showed that tumor morphology [odds ratio (OR)3.26, 95% confidence interval (CI): 1.79-5.97] and tumor rim location (OR 2.95, 95% CI: 1.16-7.46) were independent risk factors for pathological upstaging. The receiver operating characteristic curve and decision curve analysis (DCA) demonstrated the novel M-Index based on tumor morphology and rim location outperformed R.E.N.A.L, PADUA, DAP, and C-Index in the prediction of pathological upstaging (area under curve 0.756 vs. 0.728 vs. 0.641 vs. 0.661 vs. 0.743).Conclusions: Consisting of fewer non-complex parameters, the M-Index is an intuitive and practical tool with satisfactory predictive power for pathological upstaging to T3 in RCC patients undergoing surgery.

show abstract