Trends in Structure-Odor Relationship

Abstract

A number of structure-odor relationships concerning odor intensity and odor quality are presented. The sets which were used, the statistical methods which were employed and the principal results of the studies are analyzed and discussed. An attempt was made to recognize principal trends in the field of structure-odor relationships.

The Correlation and Prediction of VOC Thresholds for Nasal Pungency, Eye Irritation and Odour in Humans

“…Odor thresholds -There have been a number of early correlations of odor thresholds with various properties of odorants [27][28][29][30] but none have been very good statistically, and none have led to any conclusions of mechanistic significance. Two later studies 8 related ODT values to properties of homologous series of odorants.…”

Trigeminal Chemosensation

“…Interestingly, all these descriptors are physicochemical parameters and do not involve the precise chemical structures of the compounds. Attempts have also been made to correlate olfactory potency (Anker and Jurs, 1990;Chastrette, 1997;Dravnieks, 1977;Egolf and Jurs, 1993;Hau and Connelll, 1998;Rossiter, 1996;Schnabel, Belitz, and von Ranson, 1988;Shvets and Dimoglo, 1998). For the most part these relationships are difficult to interpret either chemically or mechanistically (Abraham, 1996).…”

Studies on the quantitative relationship between the olfactory thresholds of pyrazine derivatives and their molecular structures

“…[10] Chastrette has reviewed these studies up to 1996. [11] Yamanaka showed that odour thresholds for several homologous series could be correlated with the odorant activity coefficient in water. [12] Abraham performed a model for odour thresholds for a series of 64 compounds, including esters, aldehydes, ketones, alcohols, carboxylic acids, aromatic hydrocarbons, terpenes and other volatile organic compounds (VOCs).…”