Trends in prevalence of pre-existing diabetes and perinatal outcomes: a large, population-based study in Catalonia, Spain, 2006–2015

Gortazar, Lucía; Goday, Albert; Roux, Juana A. Flores‐Le; Sarsanedas, Eugènia; Payá, Antonio Soriano; Mañé, Laura; Pedro‐Botet, Juan; Benaiges, David

doi:10.1136/bmjdrc-2020-001254

Cited by 14 publications

(17 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of these, 743,762 (97.8%) had singleton pregnancies. Data on singleton pregnancies, regarding prevalence and trends in perinatal outcomes of women with GDM, pre-existing diabetes and without diabetes, have been published elsewhere [ 3 , 4 ].…”

Section: Resultsmentioning

confidence: 99%

“…The effect of twin gestations, glycaemic status and the interaction of both conditions on adverse perinatal outcomes are shown in Table 2 . Data on prevalence of diabetes and rates of perinatal outcomes in women according to their glycaemic status in singleton pregnancies have been published elsewhere [ 3 , 4 ].…”

Section: Resultsmentioning

confidence: 99%

“…Diabetes mellitus (DM) is the most frequent metabolic complication of pregnancy. Pre-existing diabetes and gestational diabetes mellitus (GDM) affect around 0.3–0.6% and 2–10% of pregnancies, respectively, in Europe [ 1 , 2 , 3 , 4 , 5 ], and there is evidence that the prevalence of diabetes in pregnancy is rising worldwide [ 6 , 7 , 8 ]. Women with GDM and pre-existing diabetes are at increased risk of adverse maternal and neonatal outcomes including congenital malformations, caesarean section, pre-eclampsia, macrosomia and neonatal hypoglycaemia [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Trends in Prevalence of Diabetes among Twin Pregnancies and Perinatal Outcomes in Catalonia between 2006 and 2015: The DIAGESTCAT Study

Gortazar

Roux

Benaiges

et al. 2021

JCM

Self Cite

View full text Add to dashboard Cite

The aims of our study were to evaluate the trends in the prevalence of diabetes among twin pregnancies in Catalonia, Spain between 2006 and 2015, to assess the influence of diabetes on perinatal outcomes of twin gestations and to ascertain the interaction between twin pregnancies and glycaemic status. A population-based study was conducted using the Spanish Minimum Basic Data Set. Cases of gestational diabetes mellitus (GDM) and pre-existing diabetes were identified using ICD-9-CM codes. Data from 743,762 singleton and 15,956 twin deliveries between 2006 and 2015 in Catalonia was analysed. Among twin pregnancies, 1088 (6.82%) were diagnosed with GDM and 83 (0.52%) had pre-existing diabetes. The prevalence of GDM among twin pregnancies increased from 6.01% in 2006 to 8.48% in 2015 (p < 0.001) and the prevalence of pre-existing diabetes remained stable (from 0.46% to 0.27%, p = 0.416). The risk of pre-eclampsia was higher in pre-existing diabetes (15.66%, p = 0.015) and GDM (11.39%, p < 0.001) than in normoglycaemic twin pregnancies (7.55%). Pre-existing diabetes increased the risk of prematurity (69.62% vs. 51.84%, p = 0.002) and large-for-gestational-age (LGA) infants (20.9% vs. 11.6%, p = 0.001) in twin gestations. An attenuating effect on several adverse perinatal outcomes was found between twin pregnancies and the presence of GDM and pre-existing diabetes. As a result, unlike in singleton pregnancies, diabetes did not increase the risk of all perinatal outcomes in twins and the effect of pre-existing diabetes on pre-eclampsia and LGA appeared to be attenuated. In conclusion, prevalence of GDM among twin pregnancies increased over the study period. Diabetes was associated with a higher risk of pre-eclampsia, prematurity and LGA in twin gestations. However, the impact of both, pre-existing diabetes and GDM, on twin pregnancy outcomes was attenuated when compared with its impact on singleton gestations.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Trends in Prevalence of Diabetes among Twin Pregnancies and Perinatal Outcomes in Catalonia between 2006 and 2015: The DIAGESTCAT Study

Gortazar

Roux

Benaiges

et al. 2021

JCM

Self Cite

View full text Add to dashboard Cite

show abstract

“…LGA infants were more frequently described in DM1 patients [18,19]. Another large population-based study in Catalonia [20] found a more prevalent LGA in infants of DM1 mothers. However, no relationship was found with the number of macrosomic fetuses, in line with the literature [21]: the error in the estimation of the fetal weight (10%-15%) increases as the gestational age advances, as the fetal weight increases [21].…”

Section: Discussionmentioning

confidence: 99%

Perinatal and neonatal outcomes of pregestational diabetes mellitus: a retrospective study

Capobianco

Gulotta

Tupponi

et al. 2021

Preprint

View full text Add to dashboard Cite

BackgroundThe aim of the study was to evaluate maternal-foetal and neonatal clinical outcomes in a group of patients with pregestational diabetes mellitus (PGDM) such as diabetes mellitus type 1 (DM1), diabetes mellitus type 2 (DM2), and maturity onset diabetes of the young (MODY).MethodsOverall, 174 pregnant women, nulliparous and multiparous, with single pregnancy were enrolled. The selected patients were divided into two groups: PGDM (42 with DM1, 14 with DM2, and 2 with MODY); 116 patients with a negative pathological history of diabetes mellitus were the control.ResultsWe reported an incidence of preterm delivery of 55.2% in the PGDM group, of 59.5% in the DM1 group, and 42.9% in the DM2 group VS. 6% in the controls. Foetal growth disorders, such as intrauterine growth retardation, small for gestational age, and foetal macrosomia were found in 19% and 3.6% in the case and in the control group, respectively. A relationship between DM2 and gestational hypertension was found.Conclusionspatients with PGDM are at increased risk of perinatal and neonatal complications in comparison with pregnant women without PGDM.

show abstract

“…This resistance occurs due to the production of hyperglycemic hormones and enzymes that degrade insulin, coming from the placenta. During GD, physiological changes, such as immune dysfunction and the promotion of inflammatory factors, make pregnant women even more vulnerable to viral respiratory infections, such as SARS-CoV-2 [6] [7]. For these reasons and due to the restriction of data related to DMG and the involvement by COVID-19, the importance of raising information about these two conditions is evident.…”

Section: Introductionmentioning

confidence: 99%

COVID-19 and Gestational Diabetes: A Systematic Review

Miola¹,

Santos²,

Zanuso³

et al. 2020

JDM

View full text Add to dashboard Cite

In March 2020, the World Health Organization declared a pandemic state in response to the number of infected and killed by COVID-19. Gestational diabetes (GD) is characterized by physiological changes making pregnant women even more vulnerable to viral respiratory infections, such as SARS-CoV-2. For these reasons and due to the restriction of data related to DMG and the involvement by COVID-19, the importance of raising information about these two conditions is evident. Therefore, this study aimed to perform a literature review about the complications of COVID-19 in patients with GD. MEDLINE-PubMed, EMBASE, and Scielo databases were searched and followed the PRISMA guidelines. Only four studies were included in the systematic review. The complications and mortality are more significant in pregnant women with diabetes since hyperglycemia promotes immune changes in the inflammatory state and worsens insulin resistance. The imbalance in the immune response favors the development of infections, the most likely being viral respiratory infections. On the other hand, other studies show insufficient recent evidence to indicate that pregnant women are more susceptible to infection with severe acute coronavirus respiratory syndrome. There are divergences between studies concerning complications related to COVID-19 in patients with GD. In view of this scenario and from the information obtained, it is noted that the literature is scarce regarding the worsening of COVID-19 in patients with GD. Therefore, it is necessary to continue research on these mechanisms that may justify their correlation.

show abstract

Trends in prevalence of pre-existing diabetes and perinatal outcomes: a large, population-based study in Catalonia, Spain, 2006–2015

Cited by 14 publications

References 42 publications

Trends in Prevalence of Diabetes among Twin Pregnancies and Perinatal Outcomes in Catalonia between 2006 and 2015: The DIAGESTCAT Study

Trends in Prevalence of Diabetes among Twin Pregnancies and Perinatal Outcomes in Catalonia between 2006 and 2015: The DIAGESTCAT Study

Perinatal and neonatal outcomes of pregestational diabetes mellitus: a retrospective study

COVID-19 and Gestational Diabetes: A Systematic Review

Contact Info

Product

Resources

About