Trends in prevalence and characteristics of post-neonatal cerebral palsy cases: A European registry-based study

Ehlinger, Virginie; Klapouszczak, Dana; Delobel, M.; Hollódy, Katalin; Sellier, Élodie; Cruz, Javier de la; Alberge, C.; Génolini, Christophe; Arnaud, Catherine

doi:10.1016/j.ridd.2013.02.016

Cited by 36 publications

(74 citation statements)

References 33 publications

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“…29,30 We found that CCS survivors with CND, have a greater percentage of intellectual disability and autism but a lower rate of epilepsy compared with children with CP in the literature, 31,32 including less epilepsy and visual impairment than children described in the European Registry with postnatally acquired CP. 33 The frequency of permanent hearing impairment among those with CND and those without was similar in our study; this may have been associated to ototoxicity as previously reported. 6 …”

Section: Prediction Of Cndsupporting

confidence: 88%

“…33 The majority of our patients presented with spasticity, the most common motor disorder type of CP. 34 Unilateral distribution was the most common presentation, contrasting with the literature where bilateral spastic CP is most prevalent.…”

Section: Prediction Of Cndmentioning

confidence: 87%

“…[46][47][48] Preoperative plasma lactate levels and age at surgery are modifiable variables that could potentially lead to a reduction in CND the same way other advances have affected specific prevalence rates of CP. 29,33 Specific in utero and perioperative neuroprotective strategies to achieve these goals should be further investigated. 49,50 The strengths of this study include the high proportion of children assessed at 4.…”

Section: Figurementioning

confidence: 99%

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Chronic Neuromotor Disability After Complex Cardiac Surgery in Early Life

Ricci¹,

Andersen

Joffe

et al. 2015

Pediatrics

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BACKGROUND AND OBJECTIVES: Little is known about chronic neuromotor disability (CND) including cerebral palsy and motor impairments after acquired brain injury in children surviving early complex cardiac surgery (CCS). We sought to determine the frequency and presentation of CND in this population while exploring potentially modifiable acute care predictors.METHODS: This prospective follow-up study included 549 children after CCS requiring cardiopulmonary bypass at #6 weeks of age. Groups included those with only 1 CCS, mostly biventricular CHD, and those with .1 CCS, predominantly single ventricle defects. At 4.5 years of age, 420 (94.6%) children received multidisciplinary assessment. Frequency of CND is given as percentage of assessed survivors. Predictors of CND were analyzed using multiple logistic regression analysis.RESULTS: CND occurred in 6% (95% confidence interval [CI] 3.7%-8.2%) of 4.5-year survivors; for 1 CCS, 4.2% (CI 2.3%-6.1%) and .1, 9.8% (CI 7%-12.6%). CND presentation showed: hemiparesis, 72%; spasticity, 80%; ambulation, 72%; intellectual disability, 44%; autism, 16%; epilepsy, 12%; permanent vision and hearing impairment, 12% and 8%, respectively. Overall, 32% of presumed causative events happened before first CCS. Independent odds ratio for CND are age (days) at first CCS, 1.08 (CI 1.04-1.12; P , .001); highest plasma lactate before first CCS (mmol/L), 1.13 (CI 1.03-1.23; P = 0.008); and .1 CCS, 3.57 (CI 1.48-8.9; P = .005).CONCLUSIONS: CND is not uncommon among CCS survivors. The frequency of associated disabilities characterized in this study informs pediatricians caring for this vulnerable population. Shortening the waiting period and reducing preoperative plasma lactate levels at first CCS may assist in reducing the frequency of CND. WHAT'S KNOWN ON THIS SUBJECT:Neurodevelopmental outcomes after cardiac surgery in early life provide critical information for understanding and improving care. Studies show these children are at risk for arterial ischemic stroke and acquired brain injury; further characterization of motor impairment is needed. WHAT THIS STUDY ADDS:This study focuses on the presence of chronic neuromotor disabilities including cerebral palsy and motor impairments after acquired brain injury in children surviving early complex cardiac surgery, providing information on the frequency, characteristics, and predictors that may assist in prevention.

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Section: Prediction Of Cndsupporting

confidence: 88%

Section: Prediction Of Cndmentioning

confidence: 87%

Section: Figurementioning

confidence: 99%

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Chronic Neuromotor Disability After Complex Cardiac Surgery in Early Life

Ricci¹,

Andersen

Joffe

et al. 2015

Pediatrics

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“…Regarding the characteristics of this sample, the prevalence of male gender, a non-preventable risk factor for PC, coincides with that published in the reports known in the medical literature 3,25,26 . Most of the patients had GMFCS V, coming from a referral center that serves patients with greater severity and comorbidity.…”

Section: Discussionsupporting

confidence: 86%

Morbimortalidad asociada al estado nutricional y vía de alimentación en niños con parálisis cerebral

Figueroa

Rojas²,

Barja

2017

Rev. chil. pediatr.

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“…Eleven articles reported CP prevalence within specific birth years [28,144–153] 6 studies were the first to report CP prevalence data within their respective countries [19,21,22,154–156] and 3 studies reported on regional prevalence [157–159]. Other articles addressed prevalence of comorbidities [160–166], CP registry logistics [167,168], and prevalence of term/post natal [169,170] and preterm births [171]. Surprisingly, traditional CP registries accounted for a relatively small percentage of the prevalence articles retrieved from the search (n=9).…”

Section: Resultsmentioning

confidence: 99%

Systematic Review of Cerebral Palsy Registries/Surveillance Groups: Relationships between Registry Characteristics and Knowledge Dissemination

Hurley

Sukal-Moulton

Gaebler‐Spira

et al. 2015

Int J Phys Med Rehabil

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The aims of this study were to provide a comprehensive summary of the body of research disseminated by Cerebral Palsy (CP) registries and surveillance programs from January 2009 through May 2014 in order to describe the influence their results have on our overall understanding of CP. Secondly, registries/surveillance programs and the work they produced were evaluated and grouped using standardized definitions and classification systems.MethodA systematic review search in PubMed, CINAH and Embase for original articles published from 1 January 2009 to 20 May 2014 originating from or supported by population based CP registries and surveillance programs or population based national registries including CP were included. Articles were grouped by 2009 World CP Registry Congress aim, registry/surveillance program classification, geographical region, and the International Classification of Function, Disability and Health (ICF) domain. Registry variables were assessed using the ICF-CY classification.ResultsLiterature searches returned 177 articles meeting inclusion criteria. The majority (69%) of registry/surveillance program productivity was related to contributions as a Resource for CP Research. Prevention (23%) and Surveillance (22%) articles were other areas of achievement, but fewer articles were published in the areas of Planning (17%) and Raising the Profile of CP (2%). There was a range of registry/surveillance program classifications contributing to this productivity, and representation from multiple areas of the globe, although most of the articles originated in Europe, Australia, and Canada. The domains of the ICF that were primarily covered included body structures and function at the early stages of life. Encouragingly, a variety of CP registry/surveillance program initiatives included additional ICF domains of participation and environmental and personal factors.InterpretationCP registries and surveillance programs, including novel non-traditional ones, have significantly contributed to the understanding of how CP affects individuals, families and society. Moving forward, the global CP registry/surveillance program community should continue to strive for uniformity in CP definitions, variables collected and consistency with international initiatives like the ICF so that databases can be consolidated for research use. Adaptation to new technologies can improve access, reduce cost and facilitate information transfer between registrants, researchers and registries/surveillance programs. Finally, increased efforts in documenting variables of individuals with CP into adulthood should be made in order to expand our understanding of CP across the lifespan.

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Trends in prevalence and characteristics of post-neonatal cerebral palsy cases: A European registry-based study

Cited by 36 publications

References 33 publications

Chronic Neuromotor Disability After Complex Cardiac Surgery in Early Life

Chronic Neuromotor Disability After Complex Cardiac Surgery in Early Life

Morbimortalidad asociada al estado nutricional y vía de alimentación en niños con parálisis cerebral

Systematic Review of Cerebral Palsy Registries/Surveillance Groups: Relationships between Registry Characteristics and Knowledge Dissemination

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