Trends in maternal age and the relationship between advanced age and adverse pregnancy outcomes: a population-based register study in Wuhan, China, 2010–2017

Cao, Jie; Xu, Wei; Liu, Y.; Zhang, B.; Zhang, Y.; Yu, Tao; Huang, Tao; Zou, Yuliang; Zhang, B.

doi:10.1016/j.puhe.2022.02.015

Cited by 24 publications

(14 citation statements)

References 38 publications

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“…In the US, National Vital Statistics System data revealed that the average paternal age at birth was 30.9 in 2015 (29), which was older than the mean paternal age at conception in our study (P = 0.0236). The average maternal age at conception in China in 2017 was 29.7 (30), which was also older than our research data (P <0.0001). Additionally, except for one proband (P36) who was the outcome of medically assisted reproduction, the remaining 50 pedigrees (98.04%) with de novo mutations were spontaneous conception.…”

Section: The Parental Age At Conception In De Novo Mutationscontrasting

confidence: 76%

Comparing Clinical and Genetic Characteristics of De Novo and Inherited COL1A1/COL1A2 Variants in a Large Chinese Cohort of Osteogenesis Imperfecta

Mei

Zhang

2022

Front. Endocrinol.

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PurposeNearly 85%-90% of osteogenesis imperfecta (OI) cases are caused by autosome dominant mutations of COL1A1 and COL1A2 genes, of which de novo mutations cover a large proportion, whereas their characteristics remain to be elucidated. This study aims to compare the differences in clinical and genetic characteristics of de novo and inherited COL1A1/COL1A2 mutations of OI, assess the average paternal and maternal age at conception in de novo mutations, and research the rate of nonpenetrance in inherited mutations.Materials and MethodsA retrospective comparison between de novo and inherited mutations was performed among 135 OI probands with COL1A1/COL1A2 mutations. Mutational analyses of all probands and their family members were completed by Sanger sequencing. A new clinical scoring system was developed to assess the clinical severity of OI quantitatively.ResultsA total of 51 probands (37.78%) with de novo mutations and 84 probands (62.22%) with inherited mutations were grouped by the results of the parental gene verification. The proportion of clinical type III (P<0.001) and clinical scores (P<0.001) were significantly higher in de novo mutations. Missense mutations covered a slightly higher proportion of de novo COL1A1 mutations (46.34%) compared with inherited COL1A1 mutations (33.33%), however, lacking a significant difference (P=0.1923). The mean BMD Z/T-score at the lumbar spine in de novo mutations was -2.3 ± 1.5, lower than inherited mutations (-1.7 ± 1.8), but lacking statistical significance (P=0.0742). There was no significant difference between the two groups in OI-related phenotypes (like fracture frequency, blue sclera, and hearing loss) and biochemical indexes. In de novo mutations, the average paternal and maternal age at conception was 29.2 (P<0.05) and 26.8 (P<0.0001), respectively, which were significantly younger than the average gestational age of the population. Additionally, 98.04% of pedigrees (50/51) with de novo mutations were spontaneous conception. The rate of nonpenetrance of parents with pathogenic variants in the inherited mutation group was 25.64% (20/78).ConclusionsOur data revealed that the proportion of clinical type III and clinical scores were significantly higher in de novo mutations than in inherited mutations, demonstrating that de novo mutations are more damaging because they have not undergone purifying selection.

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Section: The Parental Age At Conception In De Novo Mutationscontrasting

confidence: 76%

Comparing Clinical and Genetic Characteristics of De Novo and Inherited COL1A1/COL1A2 Variants in a Large Chinese Cohort of Osteogenesis Imperfecta

Mei

Zhang

2022

Front. Endocrinol.

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“…Studies also indicate that the risk for antenatal depression increases among women aged 30 years and older [ 5 , 6 ]. Due to the transition from the “one-child policy” to “two-child policy” in China in 2015, the average maternal age of the first pregnancy increased from 26.6 in 2010 to 27.0 in 2017 [ 7 ], and pregnancy at advanced age (30 years old or above) in Chinese women is common and continues to rise [ 8 ]. However, studies focusing on antenatal depression among Chinese women, particularly those with advanced maternal age are limited [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

The mediation role of psychological capital between family relationship and antenatal depressive symptoms among women with advanced maternal age: a cross sectional study

Zeng

Li²,

Yang³

2022

BMC Pregnancy Childbirth

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Background Due to changes in family policy in China, pregnancy at advanced age (30 years old or above) is prevalent. Advanced maternal age is known to be related to a variety of negative health outcomes, including antenatal depression. Family relationship quality might be an important factor for antenatal depressive symptoms among Chinese women with advanced maternal age. However, the underlying mechanisms in which family relationship quality can affect antenatal depressive symptoms among this population and how positive psychological capital (PsyCap) intervenes in this impact are not clear. Objectives To describe the prevalence and demographic characteristics of antenatal depressive symptoms among Chinese pregnant women with advanced maternal age, and to explore the mediation effect of PsyCap in the associations between family relationship quality and antenatal depressive symptoms. Methods We conducted a cross-sectional survey at a tertiary hospital in China. A total of 192 women with maternal age of 30 years or older completed the questionnaires. Data on antenatal depressive symptoms, PsyCap, family relationship quality and demographic characteristics were collected. The multiple mediation models in SPSS’s PROCESS macro were used to test whether PsyCap mediated the relationship between family relationship quality and antenatal depressive symptoms. Results Approximately 28.6% of participants had antenatal depressive symptoms and 6.8% reported poor family relationship quality. Participants with higher education (p = .02) and better family relationship quality (p = .00) were less likely to have antenatal depressive symptoms. PsyCap collectively (β = 1.14, p < .05), or more specifically resilience (β = 0.61, p < .05) significantly mediated the relationship between poor family relationship quality and antenatal depressive symptoms. Discussion The relationship between family relationship quality and antenatal depressive symptoms can be mediated by PsyCap collectively or via resilience specifically. It is important to screen antenatal depressive symptoms among pregnant women with advanced age, especially those who have poor family relationship quality. Counseling and psychotherapy initiatives for resilience-enhancing training for pregnant women at advanced age may provide a promising target to break the link between poor family relationship quality and antenatal depressive symptoms.

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“…Regarding fetal complications, the latest study conducted by Cao J. et al in China documented associations between advanced maternal age and risk for fetal chromosomal abnormalities, perinatal mortality, low birthweight babies, and preterm delivery [ 6 ]. Khalil et al performed a cohort study in 2013 and reported a higher risk of premature babies among women with advanced maternal ages, i.e., 35 years and above (OR 1.46, 95% CI 1.27–1.69) [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…The latest study conducted by Cao J. et al in China on the prevalence of fetomaternal complication among women of advanced ages documented associations between advanced maternal age and the risk for fetal chromosomal abnormalities, perinatal mortality, low birth weight babies, preterm delivery, and decreased fecundity [ 6 ]. Other factors contributing to its prevalence are beliefs, norms, and illiteracy, which are the main determinants that limit contraceptive use [ 5 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Other factors contributing to its prevalence are beliefs, norms, and illiteracy, which are the main determinants that limit contraceptive use [ 5 , 10 ]. HP is a burden to health care as well as to families’ economical systems [ 6 , 9 ]. It has been reported from relevant studies that most women of HP had Lower Segment Caesarean Section (LSCS) because of malpresentatmion, placenta previa, and abruptio placentae [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Fetomaternal Complications in Women of High Parity with Women of Low Parity among Saudi Women

et al. 2022

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High parity is associated with the risk of fetomaternal complications such as gestational diabetes mellitus, hypertensive disorders, maternal anemia, preterm labor, miscarriage, postpartum hemorrhage, and perinatal and preterm mortality. The objective of the study was to compare fetomaternal complications in women of high parity with women of low parity. This involved a cohort study on a sample size of 500 women who had singleton births. Data were collected from the Maternity and Child Hospital, Ha’il, Kingdom of Saudi Arabia. Participants were classified into two groups according to parity, i.e., women of low parity and women of high parity. Socio-demographic data and pregnancy complications, such as gestational diabetes, hypertension, preeclampsia, intrauterine growth restriction, etc., were retrieved from participants’ files. Participants were followed in the postnatal ward until their discharge. The results revealed that women of high parity mostly (49%) were married before 20 years of age, less educated, obese, and were of un-booked cases. Premature babies and fetal mortality are significantly high (0.000) in this group. There is a significant difference between the two groups with respect to maternal anemia, gestational diabetes mellitus, joint pain, perineal tear, miscarriage, postpartum hemorrhage, preeclampsia, vaginal tear, and cesarean section. Determinants responsible for high parity should be identified via evidence-based medicine. Public health education programs targeting couples, weight control, nutrition, and contraception would be a cost-effective strategy for reducing the risk of possible fetomaternal complications.

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Trends in maternal age and the relationship between advanced age and adverse pregnancy outcomes: a population-based register study in Wuhan, China, 2010–2017

Cited by 24 publications

References 38 publications

Comparing Clinical and Genetic Characteristics of De Novo and Inherited COL1A1/COL1A2 Variants in a Large Chinese Cohort of Osteogenesis Imperfecta

Comparing Clinical and Genetic Characteristics of De Novo and Inherited COL1A1/COL1A2 Variants in a Large Chinese Cohort of Osteogenesis Imperfecta

The mediation role of psychological capital between family relationship and antenatal depressive symptoms among women with advanced maternal age: a cross sectional study

Comparison of Fetomaternal Complications in Women of High Parity with Women of Low Parity among Saudi Women

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