Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD)

Swain, Subhashisa; Sarmanova, Aliya; Mallen, Christian; Kuo, Chien-Lin; Coupland, Carol; Doherty, Michael; Zhang, Weiya

doi:10.1016/j.joca.2020.03.004

Cited by 106 publications

(77 citation statements)

References 17 publications

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“…The data of the United Kingdom and the United States was more comprehensive and the pooled results showed that the incidence was 315 per 10,000 person-years (95% CI, 42–824) in the United Kingdom and 130 per 10,000 person-years (95% CI, 59–228) in the United States. We found that the incidence of knee OA increased with age and peaked at 70–79 years, which was consistent with the latest result of the study in the United Kingdom [15] . This may be an interesting topic, the prospective studies are warranted to validate it in future.…”

Section: Discussionsupporting

confidence: 91%

“…2020 [102] Japan 1,104 282 54; ≥20 22⋅9 661 KL≥2 2005 Cross-sectional No random Full text Swain S et al. 2020 [15] England 1,690,618 49,028 ≥20 NA NA ICD-10 codes 2017 Longitudinal NA Full text NO=numero. OA=osteoarthiritis.…”

Section: Resultsmentioning

confidence: 99%

“…2020 [109] England 93 3,575 15⋅0 45–64 All female K/L grade >2 (1988–1989)−2004 Swain S et al. 2020 [15] England 3,432 1,492,174 1⋅0 ≥20 NA CDI-10 2007 Prieto-Alhambra D et al. 2014 [16] Spain 96,222 3,266,826 4⋅5 ≥40 NA Doctor-diagnosed 2006–2010 Grotle M et al.…”

Section: Resultsmentioning

confidence: 99%

“…The criteria for study inclusion are as follows: an original study reporting the prevalence or incidence of knee OA; a study examining radiographical (femorotibial), symptomatic, or self-report knee OA; a cross-sectional or longitudinal observational study; a population-based study; on prevalence, a study collecting data from 2000 onwards; on incidence, a study collecting data from 1990 onwards. In addition, several studies reporting register primary care data [14] , [15] , [16] and claims data [17] were included, because those data were a close representation of the national population and had been validated [ 18 , 19 ]. Studies are excluded: examined individuals only with radiographically patellofemoral OA; diagnosed knee OA by MRI and ultrasonography; a hospital-based study; used sample sizes less than 150.…”

Section: Methodsmentioning

confidence: 99%

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Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies

et al. 2020

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Background Knee osteoarthritis (OA) is a major cause of disability in the elderly, however, there are few studies to estimate the global prevalence, incidence, and risk factors of knee OA. Methods For this study, we searched PUBMED, EMBASE and SCOPUS from inception to April 4, 2020, without language restriction. We identified eligible studies with information on the prevalence or incidence of knee OA in population-based observational studies and extracted data from published reports. We did random-effects meta-analysis to generate estimates. This study was registered with PROSPERO (CRD42020181035). Findings Out of 9570 records identified, 88 studies with 10,081,952 participants were eligible for this study. The pooled global prevalence of knee OA was 16⋅0% (95% CI, 14⋅3%-17⋅8%) in individuals aged 15 and over and was 22⋅9% (95% CI, 19⋅8%-26⋅1%) in individuals aged 40 and over. Correspondingly, there are around 654⋅1 (95% CI, 565⋅6–745⋅6) million individuals (40 years and older) with knee OA in 2020 worldwide. The pooled global incidence of knee OA was 203 per 10,000 person-years (95% CI, 106–331) in individuals aged 20 and over. Correspondingly, there are around annual 86⋅7 (95% CI, 45⋅3–141⋅3) million individuals (20 years and older) with incident knee OA in 2020 worldwide. The prevalence and incidence varied substantially between individual countries and increased with age. The ratios of prevalence and incidence in females and males were 1⋅69 (95% CI, 1⋅59–1⋅80, p <0⋅00) and 1⋅39 (95% CI, 1⋅24–1⋅56, p <0⋅00), respectively. Interpretation Our study provides the global prevalence (16⋅0% [95% CI, 14⋅3%-17⋅8%]) and incidence (203 per 10,000 person-years [95% CI, 106–331]) of knee OA. These findings can be used to better assess the global health burden of knee OA. Further prospective cohort studies are warranted to identify modifiable risk factors for providing effectively preventive strategies in the early stages of the disease. Funding This work was supported by grants from the (nos. 81772384 and 81572174).

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Section: Discussionsupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies

et al. 2020

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“…The UK Clinical Practice Research Datalink (CPRD) comprising data on nearly 17.5 million patients was used for a UK prevalence of osteoarthritis study (Swain et al, 2020). The standardised incidence of any OA in 2017 was 6.8 per 1000 person-years (95% CI 6.7 to 6.9) and prevalence was 10.7% (95% CI 10.7-10.8%).…”

Section: Epidemiology and Risk Factorsmentioning

confidence: 99%

Nursing people with osteoarthritis

Al-Omari

Hill

2020

Br J Nurs

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Incidence and Prevalence of Knee Osteoarthritis Using Codified and Narrative Data From Electronic Health Records: A Population‐Based Study

Arslan

Damen

Wilde

et al. 2022

Arthritis Care & Research

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Objective. To determine the incidence and prevalence of knee osteoarthritis (OA) using codified and narrative data from general practices throughout The Netherlands.Methods. This retrospective cohort study was conducted using the Integrated Primary Care Information database. Patients with codified knee OA were selected, and an algorithm was developed to identify patients with narratively diagnosed knee OA only. Point prevalence proportions and incidence rates among people age ≥30 years were assessed from 2008 to 2019. The association of comorbidities with codified knee OA was analyzed using multivariable logistic regression.Results. The positive predicted value of narratively diagnosed knee OA only was 94.0% (95% confidence interval [95% CI] 87.4-100%) and for codified knee OA 96.0% (95% CI 90.6-100%). Including narrative data in addition to codified data resulted in a prevalence 1.83-2.01 times higher (over the study years); prevalence increased from 5.8% to 11.8% between 2008 and 2019. The incidence rate was 1.93-2.28 times higher and increased from 9.98 per 1,000 person-years to 13.8 per 1,000 person-years between 2008 and 2019. Among patients with codified knee OA, 39.4% were previously diagnosed narratively with knee OA, on average ~3 years earlier. Comorbidities influenced the likelihood of being recorded with codified knee OA.Conclusion. Our study of a Dutch primary care database showed that current incidence and prevalence estimates based on codified data alone from electronic health records are underestimated. Narrative data can be incorporated in addition to codified data to identify knee OA patients more accurately.

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Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD)

Cited by 106 publications

References 17 publications

Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies

Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies

Nursing people with osteoarthritis

Incidence and Prevalence of Knee Osteoarthritis Using Codified and Narrative Data From Electronic Health Records: A Population‐Based Study

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