Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies

Abstract

Background Knee osteoarthritis (OA) is a major cause of disability in the elderly, however, there are few studies to estimate the global prevalence, incidence, and risk factors of knee OA. Methods For this study, we searched PUBMED, EMBASE and SCOPUS from inception to April 4, 2020, without language restriction. We identified eligible studies with information on the prevalence or incidence of knee OA in population-based observational studies and extracted data from published reports. We did random-effects meta-analysis to generate estimates. This study was registered with PROSPERO (CRD42020181035). Findings Out of 9570 records identified, 88 studies with 10,081,952 participants were eligible for this study. The pooled global prevalence of knee OA was 16⋅0% (95% CI, 14⋅3%-17⋅8%) in individuals aged 15 and over and was 22⋅9% (95% CI, 19⋅8%-26⋅1%) in individuals aged 40 and over. Correspondingly, there are around 654⋅1 (95% CI, 565⋅6–745⋅6) million individuals (40 years and older) with knee OA in 2020 worldwide. The pooled global incidence of knee OA was 203 per 10,000 person-years (95% CI, 106–331) in individuals aged 20 and over. Correspondingly, there are around annual 86⋅7 (95% CI, 45⋅3–141⋅3) million individuals (20 years and older) with incident knee OA in 2020 worldwide. The prevalence and incidence varied substantially between individual countries and increased with age. The ratios of prevalence and incidence in females and males were 1⋅69 (95% CI, 1⋅59–1⋅80, p <0⋅00) and 1⋅39 (95% CI, 1⋅24–1⋅56, p <0⋅00), respectively. Interpretation Our study provides the global prevalence (16⋅0% [95% CI, 14⋅3%-17⋅8%]) and incidence (203 per 10,000 person-years [95% CI, 106–331]) of knee OA. These findings can be used to better assess the global health burden of knee OA. Further prospective cohort studies are warranted to identify modifiable risk factors for providing effectively preventive strategies in the early stages of the disease. Funding This work was supported by grants from the (nos. 81772384 and 81572174).

Gender differences in osteoarthritis of knee: An Indian perspective

“…Cui et al . [ 1 ] in their meta-analysis on global incidence and prevalence of KOA in women is 1.69 (CI 95%, 1.59–1.80, P < 0.00) and 1.39 (CI 95%, 1.24–1.56, P < 0.00) times as much in males, respectively.…”

“…The literature shows a higher prevalence and incidence of KOA in women with evidence in abundance. [ 1 2 ] The gender bias is noted not only in presentation of several diseases but also in access to treatment facilities in several countries including both developed and developing countries. The cultural factors, socioeconomic status, availability of health-care facilities and geographic factors may have an impact on the prevalence of gender bias in KOA not only in India but also in the Western world too.…”

Biomarkers of Joint Damage in Osteoarthritis: Current Status and Future Directions

“…According to the Global Burden of Disease (GBD) 2017 studies, the prevalence of knee OA is positively correlated with increased age, and radiographic knee OA is more prevalent compared to systematic knee OA [3]. The population-based studies have shown that the global prevalence of knee OA was 16.0% in individuals over 15 years of age and 22.9% in individuals over 40 years of age [4]. According to a National Health Interview Survey, approximately 14 million people are affected by systematic knee OA in the United States [5].…”

Can Ultrasound Therapy Be an Environmental-Friendly Alternative to Non-Steroidal Anti-Inflammatory Drugs in Knee Osteoarthritis Treatment?

“…The prevalence of knee OA increased significantly over the last decades and continues to rise [ 4 ]. For knee OA, in 2020, the global prevalence was 16.0% (95% confidence interval (CI), 14.3–17.8%) and global incidence was 203 per 10,000 person-years (95% CI, 106–331) [ 5 ]. However, an ideal treatment for knee OA does not exist at this time [ 6 ].…”