Trends in H2S-Donors Chemistry and Their Effects in Cardiovascular Diseases

Corvino, Angela; Frecentese, Francesco; Magli, Elisa; Perissutti, Elisa; Santagada, Vincenzo; Scognamiglio, Antonia; Caliendo, Giuseppe; Fiorino, Ferdinando; Severino, Beatrice

doi:10.3390/antiox10030429

Cited by 42 publications

(49 citation statements)

References 189 publications

(259 reference statements)

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“…The involvement of H 2 S in the cardiovascular system is due to its role as a blood pressure and heart rate regulator, an activator of angiogenesis, and a basal vasorelaxant agent. Furthermore, it has been proven that antioxidation, the inhibition of cell apoptosis, pro-angiogenesis, the anti-inflammatory effect, and the regulation of ion channels represent the mechanisms of action that lead to cardioprotective activity [ 95 ].…”

Section: H 2 S Donors and Diseasesmentioning

confidence: 99%

“…Therefore, forerunners for H 2 S endogenous synthesis, H 2 S donors, and natural plant-derivative compounds may serve as strategies to prevent hypertension and kidney disease [ 94 ]. Corvino et al recently reported a survey of currently available H 2 S donors and their effects on cardiovascular disease; these H 2 S donors have been described as the basis of the mechanism that triggers the release of H 2 S and underline their possible use as favorable drugs in the treatment of cardiovascular diseases [ 95 ].…”

Section: Introductionmentioning

confidence: 99%

“…H 2 S donors, then, could represent a potential therapeutic opportunity for the treatment of COVID-19 [ 103 ]. The alteration of H 2 S levels in COVID-19 represent further evidence of the need to regulate the homeostasis of this gasotransmitter, considering that the alteration of H 2 S levels has an important role in several diseases [ 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 ].…”

Section: Introductionmentioning

confidence: 99%

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H2S Donors and Their Use in Medicinal Chemistry

Magli¹,

Perissutti²,

Santagada³

et al. 2021

Biomolecules

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Hydrogen sulfide (H2S) is a ubiquitous gaseous signaling molecule that has an important role in many physiological and pathological processes in mammalian tissues, with the same importance as two others endogenous gasotransmitters such as NO (nitric oxide) and CO (carbon monoxide). Endogenous H2S is involved in a broad gamut of processes in mammalian tissues including inflammation, vascular tone, hypertension, gastric mucosal integrity, neuromodulation, and defense mechanisms against viral infections as well as SARS-CoV-2 infection. These results suggest that the modulation of H2S levels has a potential therapeutic value. Consequently, synthetic H2S-releasing agents represent not only important research tools, but also potent therapeutic agents. This review has been designed in order to summarize the currently available H2S donors; furthermore, herein we discuss their preparation, the H2S-releasing mechanisms, and their -biological applications.

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Section: H 2 S Donors and Diseasesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

H2S Donors and Their Use in Medicinal Chemistry

Magli¹,

Perissutti²,

Santagada³

et al. 2021

Biomolecules

Self Cite

View full text Add to dashboard Cite

show abstract

“…Other naturally occurring H 2 S donors such as garlic-derived compounds or isothiocyanates present in vegetables also demonstrated cardioprotective effects [ 176 ]. Allicin, a garlic-derived H 2 S donor, is known for lowering arterial blood pressure, among other cardiovascular protection systems [ 177 ].…”

Section: H 2 S On Cardiovascular Diseasementioning

confidence: 99%

The Impact of H2S on Obesity-Associated Metabolic Disturbances

Comas

Moreno-Navarrete

2021

Antioxidants

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Over the last several decades, hydrogen sulfide (H2S) has gained attention as a new signaling molecule, with extensive physiological and pathophysiological roles in human disorders affecting vascular biology, immune functions, cellular survival, metabolism, longevity, development, and stress resistance. Apart from its known functions in oxidative stress and inflammation, new evidence has emerged revealing that H2S carries out physiological functions by targeting proteins, enzymes, and transcription factors through a post-translational modification known as persulfidation. This review article provides a critical overview of the current state of the literature addressing the role of H2S in obesity-associated metabolic disturbances, with particular emphasis on its mechanisms of action in obesity, diabetes, non-alcoholic fatty liver disease (NAFLD), and cardiovascular diseases.

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“…Exogenously added and endogenously produced hydrogen sulfide (H 2 S) influences many physiological and pathologic processes, including oxidative stress, by reacting with reactive oxygen species [ 16 , 17 ]. Organoselenium compounds have been known to serve as multifunctional agents.…”

Section: Introductionmentioning

confidence: 99%

EPR Study of KO2 as a Source of Superoxide and •BMPO-OH/OOH Radical That Cleaves Plasmid DNA and Detects Radical Interaction with H2S and Se-Derivatives

et al. 2021

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Superoxide radical anion (O2•−) and its derivatives regulate numerous physiological and pathological processes, which are extensively studied. The aim of our work was to utilize KO2 as a source of O2•− and the electron paramagnetic resonance (EPR) spin trapping 5-tert-butoxycarbonyl-5-methyl-1-pyrroline N-oxide (BMPO) technique for the preparation of •BMPO-OOH and/or •BMPO-OH radicals in water solution without DMSO. The method distinguishes the interactions of various compounds with •BMPO-OOH and/or •BMPO-OH radicals over time. Here, we show that the addition of a buffered BMPO-HCl mixture to powdered KO2 formed relatively stable •BMPO-OOH and •BMPO-OH radicals and H2O2, where the •BMPO-OOH/OH ratio depended on the pH. At a final pH of ~6.5–8.0, the concentration of •BMPO-OOH radicals was ≥20 times higher than that of •BMPO-OH, whereas at pH 9.0–10.0, the •BMPO-OH radicals prevailed. The •BMPO-OOH/OH radicals effectively cleaved the plasmid DNA. H2S decreased the concentration of •BMPO-OOH/OH radicals, whereas the selenium derivatives 1-methyl-4-(3-(phenylselanyl) propyl) piperazine and 1-methyl-4-(4-(phenylselanyl) butyl) piperazine increased the proportion of •BMPO-OH over the •BMPO-OOH radicals. In conclusion, the presented approach of using KO2 as a source of O2•−/H2O2 and EPR spin trap BMPO for the preparation of •BMPO-OOH/OH radicals in a physiological solution could be useful to study the biological effects of radicals and their interactions with compounds.

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Trends in H2S-Donors Chemistry and Their Effects in Cardiovascular Diseases

Cited by 42 publications

References 189 publications

H2S Donors and Their Use in Medicinal Chemistry

H2S Donors and Their Use in Medicinal Chemistry

The Impact of H2S on Obesity-Associated Metabolic Disturbances

EPR Study of KO2 as a Source of Superoxide and •BMPO-OH/OOH Radical That Cleaves Plasmid DNA and Detects Radical Interaction with H2S and Se-Derivatives

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