The Impact of H2S on Obesity-Associated Metabolic Disturbances

Comas, Ferran; Moreno-Navarrete, José María

doi:10.3390/antiox10050633

Cited by 21 publications

(13 citation statements)

References 195 publications

(238 reference statements)

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“…H 2 S increases glucose absorption in skeletal muscle, improves insulin sensitivity and modulates circadian clock genes in myocytes. The hypothalamic CBS (cystathionin-β-synthase)/H 2 S pathway reduces obesity [ 54 ] and improves insulin sensitivity through brain–adipose interactions. Most studies have shown that plasmatic H 2 S levels are lower in diabetic patients [ 50 , 55 ].…”

Section: Resultsmentioning

confidence: 99%

Recent Advances in Molecular Research on Hydrogen Sulfide (H2S) Role in Diabetes Mellitus (DM)—A Systematic Review

Munteanu

Rotariu

Turnea

et al. 2022

IJMS

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Abundant experimental data suggest that hydrogen sulfide (H2S) is related to the pathophysiology of Diabetes Mellitus (DM). Multiple molecular mechanisms, including receptors, membrane ion channels, signalingmolecules, enzymes, and transcription factors, are known to be responsible for the H2S biological actions; however, H2S is not fully documented as a gaseous signaling molecule interfering with DM and vascular-linked pathology. In recent decades, multiple approaches regarding therapeutic exploitation of H2S have been identified, either based on H2S exogenous apport or on its modulated endogenous biosynthesis. This paper aims to synthesize and systematize, as comprehensively as possible, the recent literature-related data regarding the therapeutic/rehabilitative role of H2S in DM. This review was conducted following the “Preferred reporting items for systematic reviews and meta-analyses” (PRISMA) methodology, interrogating five international medically renowned databases by specific keyword combinations/“syntaxes” used contextually, over the last five years (2017–2021). The respective search/filtered and selection methodology we applied has identified, in the first step, 212 articles. After deploying the next specific quest steps, 51 unique published papers qualified for minute analysis resulted. To these bibliographic resources obtained through the PRISMA methodology, in order to have the best available information coverage, we added 86 papers that were freely found by a direct internet search. Finally, we selected for a connected meta-analysis eight relevant reports that included 1237 human subjects elicited from clinical trial registration platforms. Numerous H2S releasing/stimulating compounds have been produced, some being used in experimental models. However, very few of them were further advanced in clinical studies, indicating that the development of H2S as a therapeutic agent is still at the beginning.

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Section: Resultsmentioning

confidence: 99%

Recent Advances in Molecular Research on Hydrogen Sulfide (H2S) Role in Diabetes Mellitus (DM)—A Systematic Review

Munteanu

Rotariu

Turnea

et al. 2022

IJMS

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“…The latter can react with H 2 S forming protein persulfides. However, in the obesity a decreased synthesis of H 2 S means an oxidizing environment in which protein sulfenic acids are oxidized to sulfonic acid leading to protein inactivation [ 162 ]. This hypothesis seems to be confirmed by a recent study that determined protein persulfidation in various tissues of mice under dietary restriction (DR) [ 163 ].…”

Section: Reactive Sulfur Species In Diseasesmentioning

confidence: 99%

Reactive sulfur species and their significance in health and disease

et al. 2022

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Reactive sulfur species (RSS) have been recognized in the last two decades as very important molecules in redox regulation. They are involved in metabolic processes and in this way they are responsible for maintenance of health. This review summarizes current information about the essential biological RSS, including H2S, low molecular weight persulfides, protein persulfides as well as organic and inorganic polysulfides, their synthesis, catabolism and chemical reactivity. Moreover, the role of RSS disturbances in various pathologies including vascular diseases, chronic kidney diseases, diabetes mellitus type 2, neurological diseases, obesity, chronic obstructive pulmonary disease and in the most current problem of COVID-19 is presented. The significance of RSS in aging is also mentioned. Finally, the possibilities of using the precursors of various forms of RSS for therapeutic purposes are discussed.

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“…У регуляції функціонального стану нирок важливу роль відіграє гідроген сульфід (Н 2 S), який впливає на ниркову гемодинаміку, проявляє протизапальні, протифібротичні та протиапоптичні властивості [13]. При ожирінні порушується ендогенна продукція Н 2 S, але роль цих метаболічних змін є дискутабельною [4]. Зокрема, отримані суперечливі дані щодо впливу донорів Н 2 S на масу тіла лабораторних тварин за умов високожирової дієти [7,21].…”

Section: вступunclassified

The effect of modulators of hydrogen sulfide metabolism on morphological changes in kidneys of rats with high-calorie diet-induced obesity

Blazhchenko¹,

Заічко²

2022

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. Obesity is one of the factors in the development of chronic kidney disease. Hydrogen sulfide (H2S) plays an important role in regulating the functional state of the kidneys, and its endogenous production is disrupted in obesity. The search for effective and safe correctors of H2S metabolism in the kidneys in obesity is relevant. The aim of the study was to establish the effect of potential modulators of H2S metabolism on biochemical and morphological changes in the kidneys of rats with high-calorie-diet-induced obesity (DIO). The experiments were performed on 60 white male laboratory rats in accordance with the principles of bioethics (Strasbourg, 1986; Kyiv, 2001). DIO was modeled using a high-calorie high-fat diet (39.5% fat per calorie). Metabolic correction was performed with H2S metabolism modulators (zinc sulfate, sodium thiosulfate, lipoic acid, taurine). Control rats received a standard diet (10.5% fat per calorie). Somatometric parameters, H2S level, morphological changes of kidney tissue were determined. Statistical processing was performed in the package IBM Statistics SPSS 26, differences were assessed in the Kruskel-Wallis test at a significance level of p<0.05. It was found that the development of DIO was accompanied by a decrease in the concentration of H2S in the kidneys (1.9 times, p<0.001), characteristic morphological changes in renal tissue with damage of the glomerular and tubular apparatus, severe inflammatory reaction of the parenchyma, endothelial damage and vascular structure. All metabolic correctors increased the level of H2S in the kidneys and inhibited the progression of nephropathy under the conditions of DIO. Zinc sulfate and lipoic acid were the most effective in preserving the structural elements of the renal parenchyma, while sodium thiosulfate and taurine were less effective.

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The Impact of H2S on Obesity-Associated Metabolic Disturbances

Cited by 21 publications

References 195 publications

Recent Advances in Molecular Research on Hydrogen Sulfide (H2S) Role in Diabetes Mellitus (DM)—A Systematic Review

Recent Advances in Molecular Research on Hydrogen Sulfide (H2S) Role in Diabetes Mellitus (DM)—A Systematic Review

Reactive sulfur species and their significance in health and disease

The effect of modulators of hydrogen sulfide metabolism on morphological changes in kidneys of rats with high-calorie diet-induced obesity

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