Trends in economic consequences of rheumatoid arthritis over two subsequent years

Verstappen, Suzanne M M; Jacobs, Johannes W. G.; Kruize, Aike A.; Ehrlich, J.C.; Albada‐Kuipers, G. A. Van; Verkleij, Harry; Buskens, Erik; Bijlsma, J. W. J.

doi:10.1093/rheumatology/kem018

Cited by 10 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The studies that adopted the incidence-based approach, focused on recent-onset patients and were primarily conducted in a European setting. [14][15][16][17][18][19][20][21] Cost components and measurement of direct or indirect costs also varied markedly due to the aims and data availability among studies. Twenty-seven studies reported both direct and indirect costs, while 36 studies and 9 studies reported direct and indirect costs only, respectively.…”

Section: Methodological Approachesmentioning

confidence: 99%

Economic burden of rheumatoid arthritis: a systematic review of literature in biologic era

et al. 2020

View full text Add to dashboard Cite

BackgroundThe past decades have seen rapid advances in the treatment of rheumatoid arthritis (RA). In particular, the introduction of biologic and targeted synthetic disease-modifying antirheumatic drugs have improved clinical outcomes and reconfigured traditional RA cost compositions.ObjectivesTo map the existing evidence concerning cost of illness of RA, as the treatment pathway evolves in the biologic era, and examine how costs have been measured and estimated, in order to assemble and appropriately interpret available data.MethodsSystematic review of studies that estimated the costs of patients with RA. Multiple electronic databases were searched to identify studies published between 2000 and 2019. The reported total costs and cost components were evaluated according to the study and population characteristics. The Cochran-Armitage test was used to determine statistically significant trends in increasing or decreasing proportions over time.ResultsOverall, 72 studies were included. Drug costs compromised the main component (up to 87%) of direct costs with an increasing trajectory over time, although not statistically significant. The proportion of costs for hospitalisation showed a statistically significant decrease chronologically (p=0.044). Indirect costs, primarily associated with absenteeism and work disability accounted for 39% to 86% of total costs. The reported indirect costs are highly sensitive to the approach to estimation.ConclusionsA decreasing trend in inpatient costs chronologically suggested a cost shift in other components of direct costs. Indirect costs still contributed a considerable proportion of total costs, with work disability being the main cost component. Economic analyses that do not incorporate or appropriately measure indirect costs will underestimate the full economic impact of RA.

show abstract

Section: Methodological Approachesmentioning

confidence: 99%

Economic burden of rheumatoid arthritis: a systematic review of literature in biologic era

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The addition of biological agents in treatment strategies for RA have improved the possibility of controlling disease activity5–10 and slowing the progression of joint damage 11. However, the prices of these drugs are high and several studies have proved that the use of these medications increases the overall (direct) healthcare costs of RA, despite savings in cost categories such as hospitalisation 312–14. On the other hand, it is known that the indirect costs of RA exceed direct healthcare costs.…”

mentioning

confidence: 99%

The effect of biological agents on work participation in rheumatoid arthritis patients: a systematic review

et al. 2011

View full text Add to dashboard Cite

This study reviewed the effect of biological agents on participation in paid work among patients with rheumatoid arthritis (RA). A systematic literature search was performed to identify published articles reporting the effect of biological agents on employment status, sick leave and/or presenteeism. The quality of included articles was assessed according to the guidelines as proposed by the Dutch Cochrane Centre. Narrative summaries were used to present the data separately for randomised controlled trials (RCTs) as well as controlled and uncontrolled cohort studies. 19 studies (six uncontrolled cohorts, seven controlled cohorts and six RCTs) were included, in which 11 259 patients were treated with biological agents. Employment status improved in four out of 13 studies, absence from work in all 10 studies and presenteeism in seven out of nine studies that reported this outcome. For absenteeism and presenteeism the statistical significance of change or difference was not always provided and results within studies were sometimes conflicting when using different time frames or alternative outcomes. The large heterogeneity in terms of population, design, analyses and most important in outcome measures limits interpretation of the data. RCTs as well as cohort studies showed positive results of biological agents on both absenteeism and presenteeism compared with other disease-modifying antirheumatic drugs (DMARD), continuing the failing DMARD, the general population or the situation before the start of biological agents. The effect on employment status was more conflicting, but 50% of studies that addressed patients with early methotrexate-naive RA showed a positive result on employment status.

show abstract

“…Frequency distribution of the patient's responses to selected knowledge and attitude items (patient's perspectives and awareness). literatures; Jorit et al [9] and Verstappen et al [10] who found that the majority of cases were females (86%) with a median age of (53) year. Housewives formed (64%) of the study sample, quite different from western countries, this obviously is due to the differences in cultural and environmental factors between our society and the western societies [4] [5].…”

Section: Discussionmentioning

confidence: 98%

Assessment of Knowledge and Attitude in a Sample of Patients with Rheumatoid Arthritis and Its Association with Disease Activity and Severity: A Cross-Sectional Study

Salman¹,

SAlnuaimi²,

Lateef³

et al. 2014

OJRA

View full text Add to dashboard Cite

Background: Rheumatoid arthritis (RA) is a chronic and disabling disease that has a major impact on the lives of patients. Objectives: To test the patients' knowledge about their disease, its treatment, its complications, and if this affects severity of the disease as measured by the disease activity index (DAS 28). Patients and Methods: A sample of 100 patients with RA who met the Criteria of American College of Rheumatology for RA agreed to participate in this study over the period September 2011-March 2012. Patients' data were obtained by personal interview. The questionnaire included demographic characteristics and the patients' knowledge about their disease. The disease activity was measured using standard (DAS28). Results: Thirty three percent of the patients didn't have an idea about their disease, 20% didn't know the reason for the investigations, 49% didn't know the treatment and 40% didn't know the side effects of their medications. Most patients had a high disease activity index, and there was a poor correlation between patients' educational level and the disease activity. Conclusions: Neither the educational level nor the frequency of hospital admissions had effects on the knowledge about this disease. As most patients had a high disease activity, a better knowledge may improve disease control and prevent complications.

show abstract

Trends in economic consequences of rheumatoid arthritis over two subsequent years

Cited by 10 publications

References 14 publications

Economic burden of rheumatoid arthritis: a systematic review of literature in biologic era

Economic burden of rheumatoid arthritis: a systematic review of literature in biologic era

The effect of biological agents on work participation in rheumatoid arthritis patients: a systematic review

Assessment of Knowledge and Attitude in a Sample of Patients with Rheumatoid Arthritis and Its Association with Disease Activity and Severity: A Cross-Sectional Study

Contact Info

Product

Resources

About