Trends in 3D bioprinting for esophageal tissue repair and reconstruction

Farhat, Wissam; Chatelain, François; Marret, Auriane; Faivre, Lionel; Arakélian, Lousineh; Cattan, Pierre; Fuchs, Alexandra

doi:10.1016/j.biomaterials.2020.120465

Cited by 26 publications

(22 citation statements)

References 240 publications

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“…Herein, we provide novel elastic MXene microfibers of the designed morphologies at a microscale through microfluidic technology for actual joint motion monitoring, as shown in Scheme S1. Super stretchable as well as tough hydrogels usually consist of a single or multiple gel network from double and even more polymer chains, which are both chemically (representatively through a covalent bond) and physically (representatively through intermolecular interactions) cross-linked. , Because of their sufficient water content and great biocompatibilities, superelastic hydrogels have been applied in diverse fields, including sensors, , wound healing, , drug delivery, , tissue/cartilage replacement, , etc. Although with many progresses, reports on the modification and manufacture of the structure and surface morphology of superelastic gels are still lacking.…”

Section: Introductionmentioning

confidence: 99%

Elastic MXene Hydrogel Microfiber-Derived Electronic Skin for Joint Monitoring

Guo

Zhang

et al. 2021

ACS Appl. Mater. Interfaces

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Effective and timely joint monitoring has been a significantly vital research direction in human healthcare. As an emerging technology, flexible electronics provides more possibilities and applicabilities for practical sensing and signal transmission. Here, we provide novel elastic MXene microfibers of controllable morphologies at a microscale through microfluidic technology for actual joint motion monitoring. Double-network hydrogels including covalently cross-linking polyacrylamide and ionically cross-linking alginate were chosen for superelasticity. For the improvement of the electrical conductivity of superelastic hydrogel microfibers, MXene was selected to mix with them. By introducing the cross-linker to the outer channel, microfibers with controllable diameters along with high electrical conductivities and tensile properties could be fabricated successfully. The practical value of the synthesized microfibers in joint movement sensing has been demonstrated by acting as the element of new motion sensors. Based on these features, it is believed that these elastic MXene hydrogel microfibers have high potential for rapid sensing and diagnosis of joint diseases.

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Section: Introductionmentioning

confidence: 99%

Elastic MXene Hydrogel Microfiber-Derived Electronic Skin for Joint Monitoring

Guo

Zhang

et al. 2021

ACS Appl. Mater. Interfaces

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“…Relevant research has shown that the urethra prepared by 3D bioprinting can simulate the mechanical properties and structure of human urethral tissue, which provides a new therapeutic strategy for the field of urology (Zhang et al, 2017;Agung et al, 2021). Various esophageal diseases, such as esophageal stenosis, cancer, atresia, etc., although the clinical treatment has a certain effect, may lead to many complications (Farhat et al, 2021). 3D bioprinting enables the creation of substitutes that mimic the original esophageal structure and intrinsic composition for esophageal defect repair (Takeoka et al, 2019;Nam et al, 2020).…”

Section: D Bioprinted Heart Valves Urethra and Esophagusmentioning

confidence: 99%

3D Bioprinted Scaffolds for Tissue Repair and Regeneration

et al. 2022

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Three-dimensional (3D) printing technology has emerged as a revolutionary manufacturing strategy that could realize rapid prototyping and customization. It has revolutionized the manufacturing process in the fields of electronics, energy, bioengineering and sensing. Based on digital model files, powdered metal, plastic and other materials were used to construct the required objects by printing layer by layer. In addition, 3D printing possesses remarkable advantages in realizing controllable compositions and complex structures, which could further produce 3D objects with anisotropic functions. In recent years, 3D bioprinting technology has been applied to manufacture functional tissue engineering scaffolds with its ability to assemble complicated construction under precise control, which has attracted great attention. Bioprinting creates 3D scaffolds by depositing and assembling biological and/or non-biological materials with an established tissue. Compared with traditional technology, it can create a structure tailored to the patient according to the medical images. This conception of 3D bioprinting draws on 3D printing technology, which could be utilized to produce personalized implants, thereby opening up a new way for bio-manufacturing methods. As a promising tool, 3D bioprinting can create complex and delicate biomimetic 3D structures, simulating extracellular matrix and preparing high precision multifunctional scaffolds with uniform cell distribution for tissue repair and regeneration. It can also be flexibly combined with other technologies such as electrospinning and thermally induced phase separation, suitable for tissue repair and regeneration. This article reviews the relevant research and progress of 3D bioprinting in tissue repair and regeneration in recent years. Firstly, we will introduce the physical, chemical and biological characteristics of biological scaffolds prepared by 3D bioprinting from several aspects. Secondly, the significant effects of 3D bioprinting on nerves, skin, blood vessels, bones and cartilage injury and regeneration are further expounded. Finally, some views on the clinical challenges and future opportunities of 3D bioprinting are put forward.

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“…The muscularis propria is a multi-layer structure with an inner ring and an outer longitudinal shape, called the circular muscle and the longitudinal muscle. The cells mainly include mucosal epithelial cells (ECs) and smooth muscle cells (SMCs) ( Peirlinck et al, 2018 ; Blank et al, 2019 ; Farhat et al, 2021 ) ( Figure 1 ). Therefore, as an ideal esophageal tissue engineering scaffold and a bionic multi-layer structure of the esophagus, it is endowed with corresponding supporting functions for different parts.…”

Section: Introductionmentioning

confidence: 99%

Development and Prospect of Esophageal Tissue Engineering

Fang

et al. 2022

Front. Bioeng. Biotechnol.

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Currently, patients with esophageal cancer, especially advanced patients, usually use autologous tissue for esophageal alternative therapy. However, an alternative therapy is often accompanied by serious complications such as ischemia and leakage, which seriously affect the prognosis of patients. Tissue engineering has been widely studied as one of the ideal methods for the treatment of esophageal cancer. In view of the complex multi-layer structure of the natural esophagus, how to use the tissue engineering method to design the scaffold with structure and function matching with the natural tissue is the principle that the tissue engineering method must follow. This article will analyze and summarize the construction methods, with or without cells, and repair effects of single-layer scaffold and multi-layer scaffold. Especially in the repair of full-thickness and circumferential esophageal defects, the flexible design method and the binding force between the layers of the scaffold are very important. In short, esophageal tissue engineering technology has broad prospects and plays a more and more important role in the treatment of esophageal diseases.

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Trends in 3D bioprinting for esophageal tissue repair and reconstruction

Cited by 26 publications

References 240 publications

Elastic MXene Hydrogel Microfiber-Derived Electronic Skin for Joint Monitoring

Elastic MXene Hydrogel Microfiber-Derived Electronic Skin for Joint Monitoring

3D Bioprinted Scaffolds for Tissue Repair and Regeneration

Development and Prospect of Esophageal Tissue Engineering

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