Trends and differences in tuberculosis incidences and clustering among natives in Denmark, Sweden and Finland: comparison of native incidences and molecular epidemiology among three low-incidence countries

Pedersen, Maria; Lillebæk, Troels; Andersen, Aase Bengaard; Soini, Hanna; Haanperä, Marjo; Groenheit, Ramona; Jonsson, Jerker; Svensson, Erik

doi:10.1016/j.cmi.2017.10.005

Cited by 6 publications

(6 citation statements)

References 13 publications

(13 reference statements)

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“…These results are encouraging in terms of the National TB control program. However, Finland and Sweden have observed a more rapid decline in TB incidence among their native populations 31 . More than 6% of cases in Denmark interrupted TB treatment, this group of patients potentially pose a risk of disease progression at the individual level leading to continuous transmission in the society.…”

Section: Discussionmentioning

confidence: 99%

Predictors for Pulmonary Tuberculosis Treatment Outcome in Denmark 2009–2014

Holden

Lillebæk

Seersholm

et al. 2019

Sci Rep

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Monitoring of tuberculosis (TB) treatment outcome is essential to ensure an effective TB control program. In this nationwide retrospective cohort study from Denmark we present TB treatment outcome rates and risk factors associated with an unfavourable outcome. All patients notified with pulmonary TB from 2009 through 2014 were included. Logistic regression analyses were used to identify risk factors for unfavourable outcome. In total, 1681 pulmonary TB cases were included. TB treatment success rates increased during the study period. In 2014, the treatment success rate reached 85% for new culture positive cases whereas 7% cases interrupted treatment. The mortality decreased during the study period from 12.3% to 4.1%. Several risk factors associated with unfavourable outcome were identified in a multivariable model: male (OR: 2.56), Greenlandic origin (OR: 1.80), abuse of alcohol (OR: 2.90), history of mental disorder (OR: 2.46), and anaemia at time of treatment initiation (OR: 1.92). In a TB low incidence setting such as the Danish, it is important to maintain focus on preventing an unfavourable TB outcome. Patient management and treatment can be optimized by taking into consideration risk factors such as those identified in the present study.

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Section: Discussionmentioning

confidence: 99%

Predictors for Pulmonary Tuberculosis Treatment Outcome in Denmark 2009–2014

Holden

Lillebæk

Seersholm

et al. 2019

Sci Rep

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“…in the Nordic countries (Denmark, Sweden and Finland) in the periods 2012-2013 and 2014-2015. [20] It is lower than that found in Germany, Finland and the Netherlands, all countries with low TB incidence and effective control programs. [21–23]…”

Section: Discussionmentioning

confidence: 96%

Genetic patterns, sublineages and dynamics of tuberculosis transmission in Cuba, a low burden country

Martinez-Rodriguez,

Herrera-Avila,

Goza-Valdes

et al. 2024

Preprint

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Context: In Cuba, a country with a low incidence of tuberculosis (TB), there is no information on the dynamics of transmission of the disease for two decades. Aims: Determine the genetic patterns and sublineages of Mycobacterium tuberculosis complex (MTBC) isolates circulating in 2009 and their relationship with the epidemiological data of the patients. Settings and Design: A retrospective descriptive study was carried out in Cuba with 178 MTBC isolates. Methods and Material: Spoligotyping and mycobacterial interspersed repetitive unit variable number tandem repeat (MIRU-VNTR) typing with 24 loci were performed. Statistical analysis used: Nonparametric methods, analysis of variance and homogeneity test, using the statistical package Statgraphics Plus version 2.1 were used. Results: Spoligotyping produced 39 spoligotypes. The S, Beijing, LAM and Haarlem sublineages prevailed. The clustering rate was 75.84% and the Hunter-Gaston discriminatory index (HGDI): 0.8734. MIRU-VNTR typing with 24 loci defined 154 genetic patterns: six grouped 30 isolates and 148 showed unique patterns. The clustering rate was 14.60% and the HGDI: 0.9926. There was a predominance of sublineages by region: S, Beijing and LAM in the West, Center and East, respectively. Conclusions: The dynamics of TB transmission in Cuba in 2009 is reported, inferring that this occurs in a limited manner and belonging to risk groups does not favor transmission. It serves to evaluate a megaproject of the Global Fund to reduce the transmission of TB in this country. The population genetic structure of MTBC resembles that of an Ibero-American country, with the exception of the high frequency of the Beijing and S sublineages.

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“…In spite of this effort, it was not possible to identify source cases to all children with TB disease, which is a shortcoming that needs to be addressed by relevant authorities in the years to come. It is worrying that Denmark compared with other Scandinavian countries seems to have a larger degree of recent TB transmission and less effective TB prevention and control as remarked in a recently published study (20). Earlier identification of adults with TB disease may prevent transmission or allow for preventive treatment before progression to disease (21).…”

Section: Source Case and Contact Investigationmentioning

confidence: 99%