Tuberculosis Transmission in Danish Children: A Nationwide Register-based Study

Nordholm, Anne Christine; Holm, Line Lindebo; Svensson, Erik; Andersen, Peter Henrik; Johansen, Işik Somuncu

doi:10.1097/inf.0000000000002139

Cited by 8 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The occurrence of TB in young children is a well‐known marker of ongoing transmission of the infection in a society. National register studies of TB in children <15 years from Denmark and Switzerland reported median ages of five years . The results of the Danish study imply a gap in early detection of TB transmitted to small children.…”

Section: Discussionmentioning

confidence: 83%

Foreign background and older age of children were associated with infection in Swedish tuberculosis contacts

2020

View full text Add to dashboard Cite

Aim We present our results using interferon‐gamma release assays in any child <18 years or tuberculin skin tests in Bacille Calmette‐Guérin unvaccinated children for tuberculosis contact investigation in Stockholm, Sweden. Methods During 2000—2019, we investigated 892 children with a median age of seven years. We explored associations between TB infection and characteristics such as closeness to contact, age, sex, BCG status and foreign origin. Results The overall rates were for TB infection 10.2% (n = 91) and for TB disease 1.1% (n = 10). In addition to infectiousness of index case and closeness of contact, foreign background, male sex and increasing age were independently associated with infection. In foreign‐born children, the rates of tuberculosis infection and disease were 18.7% and 3.9%, respectively. In 18/46 (39%) infected foreign‐born children, a baseline negative tuberculosis test supported a diagnosis of recent infection. Conclusion Foreign background, older age and male sex were associated with infection. In a significant proportion of infected children, a previous negative test made recent infection likely.

show abstract

Section: Discussionmentioning

confidence: 83%