Trends Analysis of Clinical Studies on Korean Medicine for Infertility

So, Min-Ji; Lee, Yoon Jae; Kim, Suhyun; Jang, Jun‐Bock; Deok-Sang, Hwang; Kim, Dong-Il

doi:10.15204/jkobgy.2017.30.1.042

Cited by 4 publications

(3 citation statements)

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“…Moreover, very few studies have been conducted to collect evidence of KM treatment effects on unexplained infertility. [ 15 ]…”

Section: Introductionmentioning

confidence: 99%

The effectiveness, safety, and economic evaluation of Korean medicine for unexplained infertile women

Kim

2017

Medicine

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Infertility is a condition in which a woman has not been pregnant despite having had normal intercourse for 1 year. The number of unexplained infertile females is increasing because of late marriage customs, as well as environmental and lifestyle habits. In Korea, infertile females have been treated with Korean medicine (KM). However, these effects have not been objectively confirmed through clinical trials. Therefore, this study was conducted to demonstrate the effectiveness of herbal medicine treatment in infertile patients and to demonstrate the economic feasibility through economical evaluation with assisted reproductive technology.This study is designed as a multicenter, single-arm clinical trial. All participants included will be from 3 Korean Medicine hospitals in Korea and will voluntarily sign an informed consent agreement. All recruited patients will conduct related surveys and tests, and be provided with treatment according to their menstrual cycle. Patients will take herbal medicines for 4 menstruation cycles and receive acupuncture and moxibustion treatment at 3 times (menstrual cycle day 3, 8, 14) during 4 menstruation cycles. They will also undergo an approximately 4 menstrual cycle treatment period, and 3 menstrual cycle observation period. If pregnant during the study, participants will take the herbal medicine for implantation for about 15 days. In this study, the primary outcome will be the clinical pregnancy rate, whereas the secondary outcome will include the implantation rate, ongoing pregnancy rate, and live birth rate.Ultimately, this study will provide clinical data regarding the effectiveness and safety of KM treatment for females with unexplained infertility and important evidence for establishing standard KM treatments for unexplained infertility. Moreover, we will identify the most cost-effective way to treat unexplained infertility.

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“…Moreover, very few studies have been conducted to collect evidence of KM treatment effects on unexplained infertility. [ 15 ]…”

Section: Introductionmentioning

confidence: 99%

The effectiveness, safety, and economic evaluation of Korean medicine for unexplained infertile women

Kim

2017

Medicine

Self Cite

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“…However, clinical trials have tested only the clinical efficacy and safety of single treatments and have ignored the complexities of KM interventions. 9 A recent multicenter observational study tested the effects of herbal medicines with acupuncture in women with unexplained infertility. 10 …”

Section: Introductionmentioning

confidence: 99%

Characteristics and Outcomes of Herbal Medicine for Female Infertility: A Retrospective Analysis of Data from a Korean Medicine Clinic During 2010–2020

Kim¹,

Lee²,

Kim³

et al. 2022

IJWH

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Purpose Few studies have assessed outcomes associated with the use of traditional medicine therapies to manage infertility in clinical practice. The aim of this study was to investigate the clinical characteristics of and infertility treatment effects among patients who visited a Korean medicine (KM) clinic to aid in achieving pregnancy. This study consisted of a 10-year analysis of patient records from a KM clinic. Methods A retrospective 10-year (2010–2020) chart analysis was performed using the medical records of infertile patients who visited a KM clinic in South Korea for fertility treatment (ICD-10, infertility symptoms: 59 codes). Results Of the 6194 patients who visited the clinic during the selected time frame, 1786 were female patients seeking fertility treatment to achieve pregnancy. Among the 1786 infertile women, 586 women succeeded in becoming pregnant (32.8%). Among the 586 patients who became pregnant, 476 women had received KM, 92 had been treated using KM and in vitro fertilization (IVF), and 18 had received KM and undergone intrauterine insemination (IUI). The live birth rates achieved with these treatments were 66.0%, 68.8%, and 66.7%, respectively. The most frequently prescribed medicines were Gamiboher-tang (Jiaweiwuxu-tang), Gamiguibi-tang (Jiaweiguipi-tang), and Gamidanggui-san (Jiaweidanggui-san). Additionally, the most frequent adjunct therapies administered to these patients were acupuncture and moxibustion. Conclusion Infertility therapies using KM may be a successful option to treat infertility when used alone or in addition to IVF and IUI. However, further pharmacological investigations and clinical trials are required to ensure the objectivity of the efficacy evaluation.

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“… 5 In most cases, a combination of KM and conventional treatments were recommended. 6 Several studies reported that complementary treatments increase the success rate of the In Vitro Fertilization(IVF) treatment, 7 , 8 and Korean medicine by itself provided before IVF increases the likelihood of a successful natural pregnancy, while it also relieves menstrual cramping and increases hematological parameter stability of patients. 9 , 10 …”

Section: Introductionmentioning

confidence: 99%

A qualitative study on the experience of acupuncture treatment in infertile women

Min

Lee

et al. 2021

Integrative Medicine Research

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Background This study aimed to record and analyze the experiences of infertile women who underwent acupuncture treatment. Methods This is a qualitative study in which in-depth interviews were conducted with women who underwent acupuncture as a treatment for infertility from the viewpoint of phenomenology, a method of understanding human behavior in the general human and social context, and grasping the nature of the experience in depth. The study participants were 12 women who had been receiving acupuncture treatment for infertility for more than 3 months. Results After analyzing the statements of the participants’ experiences, the main concerns regarding infertility were "embarrassed by unexpected infertility," "overwhelmed with negative feelings," "blocking and defense," “sex as a duty,” and “repeatition of expectations and failures.” Significant statements regarding acupuncture treatments were “body warmth,” “becoming a body,” “care of the mind,” “last trust and hope,” and “difficulties of waiting.” The experience with supporter was love-hate relationships, and the experience of the children’s meaning was expressed as “precious beings in life.” Conclusion The results of this study suggest that acupuncture treatment for infertility in women results in positive thinking through changes in the body as well as through increased hope. Participants experienced a feeling of warmth in their bodies, regular menstrual cycle, and reduced fatigue through acupuncture treatment, indicating a state of psychological stability.

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Trends Analysis of Clinical Studies on Korean Medicine for Infertility

Cited by 4 publications

References 0 publications

The effectiveness, safety, and economic evaluation of Korean medicine for unexplained infertile women

The effectiveness, safety, and economic evaluation of Korean medicine for unexplained infertile women

Characteristics and Outcomes of Herbal Medicine for Female Infertility: A Retrospective Analysis of Data from a Korean Medicine Clinic During 2010–2020

A qualitative study on the experience of acupuncture treatment in infertile women

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