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We show local Hölder continuity of quasiminimizers of functionals with nonstandard (Musielak-Orlicz) growth. Compared with previous results, we cover more general minimizing functionals and need fewer assumptions. We prove Harnack's inequality and a Morrey type estimate for quasiminimizers. Combining this with Ekeland's variational principle, we obtain local Hölder continuity for ω-minimizers.

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Brazilin, isolated from the methanol extract of the heart wood of Caesalpinia sappan, sensitizes cancer cells to apoptosis. Glioblastoma multiforme (GBM), which accounts for most cases of central nervous system malignancy, has a very poor prognosis and lacks effective therapeutic interventions. We, therefore, investigated the effects of different concentrations of and different periods of exposure to brazilin on cell proliferation and apoptosis in the glioma U87 cell line. Cell proliferation was investigated by MTT assays and growth curve analysis, apoptosis was assessed by FACS analysis and western blot studies. Brazilin showed dose-dependent inhibition of cell proliferation and induction of apoptosis in glioma cells. It also increased the ratio of cleaved poly-(ADP)-ribose polymerase and decreased the expression of caspase-3 and caspase-7.

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