Trending Anti-Aging Peptides

Abstract

The development of synthetic peptides for skin care dates to the 1980s. The cosmetic industry periodically launches new peptides, as they are promising and appealing active ingredients in the growing and innovative cosmetics market. In this study, trends in the use of peptides in anti-aging products were analyzed by comparing the composition of the products marketed in 2011 with products launched or reformulated in 2018. The scientific and marketing evidence for their application as active ingredients in anti-aging cosmetics was also compiled from products’ labels, suppliers’ technical data forms and online scientific databases. The use of peptides in anti-aging cosmetics increased by 7.2%, while the variety and the number of peptide combinations in products have increased by 88.5%. The most used peptides in antiaging cosmetic formulations are, in descending order, Palmitoyl Tetrapeptide-7, Palmitoyl Oligopeptide and Acetyl Hexapeptide-8. In 2011, the majority of peptides were obtained from synthesis, while in 2018, biotechnology processing was the dominant source. This study provides an overview of the market trends regarding the use of peptides in anti-aging products, providing meaningful data for scientists involved in the development of new peptides to identify opportunities for innovation in this area.

Truths and myths about marketed anti-aging skin products: a systematic review

“…However, the fastest results can be obtained by undergoing a cosmetic procedure. 21 This clarifies that the optimal results obtained from the use of anti-aging products, if they are effective are slow.…”

Neurocosmetics in Skincare—The Fascinating World of Skin–Brain Connection: A Review to Explore Ingredients, Commercial Products for Skin Aging, and Cosmetic Regulation

“…Progeline™ by LUCAS MEYER [300], a three-amino-acid biomimetic peptide (trifluoroacetyl tripeptide-2), was thus developed to improve wrinkles and sagging skin by modulating progerin [301,302]. More specifically, this active compound decreases progerin synthesis and accumulation, and inhibits metalloproteinases [297,303].…”

“…Several companies, such as PHARMASPECIAL ® , GALENA ® , BIOTEC ® , LIPOTEC ® , and SILAB ® , are investing in technologically innovative signal-and neurotransmitter-inhibitor peptides particularly indicated as anti-aging ingredients for the formulation of skincare products [110,303].…”

“…In this regard, however, it should be noted that the high efficacy compensates for the cost. In other words, for the formulation of cosmetic products, it is possible to employ these peptides in low amounts [303,343].…”

“…Topical peptides can be classified as signals, carriers, enzyme inhibitors, or neurotransmitter inhibitors [110,301,303,335,346].…”