Trend of neonatal group B streptococcal infection during the last 15 years

Hoshina, Kiyoshi; Suzuki, Yoko; Nishida, Hiroshi; Kaneko, Kazuma; Matsuda, Seiji; Kobayashi, Masumi; Kadoi, Nobuaki

doi:10.1046/j.1442-200x.2002.01638.x

Cited by 27 publications

(21 citation statements)

References 7 publications

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“…The majority of erythromycin-and clindamycinresistant GBS were from serotype III, one of the most frequent serotype causing neonatal GBS disease (10,12,14,32). This result differs from previous studies (10)(11)(12)22) that identified serotype V to be associated with erythromycin resistance.…”

Section: Discussioncontrasting

confidence: 80%

Characterization of Group B Streptococcus Isolated from Women in Saitama City, Japan

et al. 2012

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SUMMARY: Streptococcus agalactiae (group B streptococcus; GBS) is a common cause of neonatal sepsis and meningitis. Intrapartum antibiotic prophylaxis is effective in reducing neonatal GBS disease. Penicillin is recommended for intrapartum antibiotic prophylaxis; however, other antibiotics are administered to pregnant women with penicillin allergy. Serotyping and antibiotic susceptibility testing were performed on 376 GBS isolates collected from vaginal swabs in Saitama City. Of the 376 isolates, 328 (87.2z) were obtained from obstetrics and gynecology clinics. Although approximately 80z of the isolates (299/376) were from women of reproductive age (age, 15-49 years), no definite information on their pregnancy status was obtained. The most frequent serotype was V (19.1z) followed by Ib (18.6z), III (16.2z), VI (14.9z), and Ia (14.6z). None of the isolates were resistant to penicillins and cephalosporins. Isolates that were resistant to erythromycin (12.8z), clindamycin (9.0z), ofloxacin (19.4z), levofloxacin (18.4z), and tetracycline (46.5z) were detected. There was a high prevalence of resistance to erythromycin (39.3z) and clindamycin (27.9z) in serotype III. In addition, almost all serotype Ib isolates were resistant to ofloxacin and levofloxacin (both, 91.4z). Pulsed-field gel electrophoresis analysis on certain GBS isolates (serotype Ib, III, and V) indicated that there was genetic diversity among the resistant isolates obtained from a limited area of Japan. In conclusion, present intrapartum antibiotic prophylaxis with penicillins would be effective in Japan; however, performing susceptibility testing before administering other antibiotics is important in order to ensure activity against the relevant isolate.

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Section: Discussioncontrasting

confidence: 80%

Characterization of Group B Streptococcus Isolated from Women in Saitama City, Japan

et al. 2012

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“…The light gray areas indicate the additive areas in which the concentrations of L-ficolin and serotype-specific IgG would achieve bactericidal indexes equivalent to those in the corresponding sera (i.e., between 50.4 and 62.5% for serotype III and between 55.0 and 67.9% for serotype V) and k, the FBC index, would be equal to 1. bactericidal index was high, however, and serum opsonized the bacteria effectively, independent of L-ficolin and serotype-specific IgG concentrations. This observation may help explain the discrepancy between the high rate of maternal colonization and the low incidence of early-onset disease associated with serotype VIII in Japan (10,16,23).…”

Section: Discussionmentioning

confidence: 95%

L-Ficolin and Capsular Polysaccharide-Specific IgG in Cord Serum Contribute Synergistically to Opsonophagocytic Killing of Serotype III and V Group B Streptococci

et al. 2012

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ABSTRACTGroup B streptococci (GBS;Streptococcus agalactiae) are the most common cause of neonatal sepsis and meningitis. Serotype-specific IgG antibody is known to protect neonates against GBS infections by promoting opsonophagocytosis. The L-ficolin-mediated lectin pathway of the complement is also a potential mechanism for opsonization of GBS, because L-ficolin activates the complement after binding to serotype Ib, III, V, VI, and VIII GBS. In the present study, we investigated how L-ficolin and serotype-specific IgG in cord sera contribute to opsonophagocytic killing of GBS. Neither L-ficolin nor serotype-specific IgG concentrations correlated with C3b deposition on serotype Ib and VI GBS, suggesting L-ficolin- and serotype-specific IgG-independent mechanisms of complement activation. The percentage of serotype VIII GBS killed was high regardless of the concentration of L-ficolin and IgG. In contrast, L-ficolin and serotype-specific IgG can each initiate C3b deposition on serotype III and V GBS and promote phagocytosis by polymorphonuclear leukocytes, but L-ficolin and serotype-specific IgG together promote opsonophagocytic killing to a greater extent than does either alonein vitro. This synergy was observed when serotype III-specific IgG concentrations were between 1 and 6 μg/ml and when serotype V-specific IgG concentrations were between 2 and 5 μg/ml. Concentrations of serotype III-specific IgG in cord blood above 7 μg/ml are considered protective for neonates colonized with GBS, but most neonates with IgG levels of less than 7 μg/ml do not develop GBS infections. The data presented here suggest that L-ficolin enhances opsonophagocytosis of serotype III and V GBS when serotype-specific IgG alone is suboptimal for protection.

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“…agalactiae was the most frequent pathogen for meningitis in infants and small children. Hoshina et al [8] conducted a questionnaire survey of infection by S. agalactiae in Japan, reporting that death or sequelae were noted in 22.6% of early-onset-type cases and 38.7% of delayed-onset-type cases. In this survey, the percentage of patients having sequelae at the end of treatment was high (30.4%) among patients with meningitis caused by this bacterium.…”

Section: Discussionmentioning

confidence: 99%

Results of a multicenter survey of diagnosis and treatment for bacterial meningitis in Japan

Sakata

Sato

Nonoyama

et al. 2010

Journal of Infection and Chemotherapy

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Trend of neonatal group B streptococcal infection during the last 15 years

Abstract: The number of GBS-infected cases has stopped increasing, but it is still necessary to carry out screenings of pregnant women for the purpose of decreasing the onset of the disease.

Cited by 27 publications

References 7 publications

Characterization of Group B Streptococcus Isolated from Women in Saitama City, Japan

Characterization of Group B Streptococcus Isolated from Women in Saitama City, Japan

L-Ficolin and Capsular Polysaccharide-Specific IgG in Cord Serum Contribute Synergistically to Opsonophagocytic Killing of Serotype III and V Group B Streptococci

Results of a multicenter survey of diagnosis and treatment for bacterial meningitis in Japan

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