Results of a multicenter survey of diagnosis and treatment for bacterial meningitis in Japan

Sakata, Hiroshi; Sato, Yoshitake; Nonoyama, Masato; Haruta, T; Ouchi, Kazunobu; Yamaguchi, Satoru; Sunakawa, Keisuke

doi:10.1007/s10156-010-0064-6

Cited by 14 publications

(17 citation statements)

References 9 publications

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“…Male sex predominated in the patents in our study in accordance with the literature ( 1 , 2 , 4 – 8 , 10 , 12 , 13 , 18 ). Three of the four patients who died were male.…”

Section: Discussionsupporting

confidence: 92%

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Kliniğimizde 1992–2011 yılları arasında akut bakteriyel menenjit tanısıyla yatarak tedavi gören hastalarda erken komplikasyonlarla ilişkili etmenler

Bor

2020

Turk Pediatri Ars

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Aim: To evaluate factors associated with the development of early complications in acute bacterial meningitis. Material and Methods: In our study, 389 patients diagnosed with acute bacterial meningitis between January 1992 and January 2011 at Cerrahpaşa Medical Faculty were retrospectively analyzed to determine the risk factors for the development of early complications. Results: The causative agent was N. meningitidis in 17% of cases, S. pneumoniae in 13.6%, and H. influenzae type b in 6.4%. In 55.5% of cases, the causative agent could not be identified. The mortality rate was found as 1% and the early complication rate was 27.8%. The complications observed included septic shock and disseminated intravascular coagulation (33.3%), hydrocephalus (23.1%), subdural effusion (19.4%), and epilepsy (12%). Risk factors for early complications included being aged below two years (p<0.010), restlessness (p<0.010), rash (p<0.010), leukocytosis in complete blood count (p<0.010), and a cerebrospinal fluid glucose level of <45 mg/dL (p<0.010). Three of the four patients who died were male. The incidence of hydrocephalus was higher in patients who used ampicillin-cefotaxime and who did not receive steroid therapy before treatment (p<0.050). Conclusion: When acute bacterial meningitis is treated properly and adequately, recovery without sequela is possible. Knowing the risk factors for early complications will guide in the monitoring of patients and decrease morbidity and mortality rates.

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“…Male sex predominated in the patents in our study in accordance with the literature ( 1 , 2 , 4 – 8 , 10 , 12 , 13 , 18 ). Three of the four patients who died were male.…”

Section: Discussionsupporting

confidence: 92%

“…Most of our patients (67.4%) were aged below five years, similar to worldwide data ( 1 , 2 , 4 , 6 – 13 ). The frequency of complications was increased below the age of two years, and intensified between the ages of three months and five years.…”

Section: Discussionsupporting

confidence: 90%

Kliniğimizde 1992–2011 yılları arasında akut bakteriyel menenjit tanısıyla yatarak tedavi gören hastalarda erken komplikasyonlarla ilişkili etmenler

Bor

2020

Turk Pediatri Ars

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“…It is the commonest cause of bacterial meningitis in the USA and many countries worldwide (2,3). Despite effective antimicrobial therapy, pneumococcal meningitis remains highly lethal and has substantial long-term sequelae (4,5).…”

Section: Introductionmentioning

confidence: 99%

Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice

et al. 2012

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Streptococcus pneumoniae is the most common cause of severe bacterial meningitis in children, the elderly, and immunocompromised individuals. To identify virulence factors preferentially expressed during meningitis, we conducted niche-specific genome-wide in vivo transcriptomic analysis after intranasal infection of mice with serotype 4 or 6A pneumococci. The expression of 34 bacterial genes was substantially altered in brain tissue of mice infected with either of the 2 strains. Ten upregulated genes were common to both strains, 7 of which were evaluated for their role in the development of meningitis. One previously uncharacterized protein, α-glycerophosphate oxidase (GlpO), was cytotoxic for human brain microvascular endothelial cells (HBMECs) via generation of H 2 O 2 . A glpO deletion mutant was defective in adherence to HBMECs in vitro as well as in progression from the blood to the brain in vivo. Mutant bacteria also induced markedly reduced meningeal inflammation and brain pathology compared with wild type, despite similar levels of bacteremia. Immunization of mice with GlpO protected against invasive pneumococcal disease and provided additive protection when formulated with pneumolysin toxoid. Our results provide the basis of a strategy that can be adapted to identify genes that contribute to the development of meningitis caused by other pathogens.

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“…The reasons for the re-emergence of Hib are multifactorial and still controversial: (1) vaccine failure due to an early and short vaccination schedule without a booster, (2) vaccine failure due to combination vaccines that contain acellular pertussis, (3) reduction of herd immunity due to a decrease of natural boosting by asymptomatic colonization, and (4) the emergence of new clones [4].…”

Section: Introductionmentioning

confidence: 99%

“…In Japan, a country-wide surveillance study that was undertaken prior to the introduction of Hib immunization (2004)(2005)(2006)(2007) demonstrated that H. influenzae pathogens, including Hib, were the most frequently identified (63.5%) among meningitis cases in children [2].…”

Section: Introductionmentioning

confidence: 99%

Genotyping of Haemophilus influenzae type b in pre-vaccination era

Otsuka

Komiyama

Yoshida

et al. 2012

Journal of Infection and Chemotherapy

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Results of a multicenter survey of diagnosis and treatment for bacterial meningitis in Japan

Cited by 14 publications

References 9 publications

Kliniğimizde 1992–2011 yılları arasında akut bakteriyel menenjit tanısıyla yatarak tedavi gören hastalarda erken komplikasyonlarla ilişkili etmenler

Kliniğimizde 1992–2011 yılları arasında akut bakteriyel menenjit tanısıyla yatarak tedavi gören hastalarda erken komplikasyonlarla ilişkili etmenler

Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice

Genotyping of Haemophilus influenzae type b in pre-vaccination era

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