Trend of incidence, subsite distribution and staging of colorectal neoplasms in the 15-year experience of a specialised cancer registry

Leòn, Maurizio Ponz de; Marino, Massimiliano; Benatti, Piero; Rossi, Giuseppina; Menigatti, Mirco; Pedroni, Monica; Gregorio, Carmela Di; Losi, Lorena; Borghi, Francesca; Scarselli, A; Ponti, Giovanni; Roncari, Barbara; Zangardi, G.; Abbati, G.; Ascari, E; Roncucci, Luca

doi:10.1093/annonc/mdh224

Cited by 55 publications

(58 citation statements)

References 31 publications

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“…CRC has a tendency to increase with advancing age along with fairly rare incidence below 40 years of age, especially in western world (Ponz de Leon et al, 2004). This increasing trend with age is seen in this study as well.…”

Section: Discussionsupporting

confidence: 82%

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Patients' Profile, Clinical Presentations and Histopathological Features of Colo-rectal Cancer in Al Hassa Region, Saudi Arabia

Amin¹,

Suleman²,

Taissan³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background: Patients' demographics, presenting clinical and histopathological features for colo-rectal cancer (CRC) are important factors for patients' outcome and disease prognosis. This study aimed to describe the pattern of CRC in terms of patients' demographics, main presenting symptoms and histopathological features in Al Hassa region of Saudi Arabia. Subjects and Methods: A retrospective hospital records-based study which included reviewing of patients' records diagnosed with CRC at three general hospitals in Al Hassa region, Saudi Arabia. A compilation form was designed to collect information regarding socio-demographics, age at diagnosis; referral sites and the main presentations at CRC diagnosis. sites and the main presentations at CRC diagnosis. Histopathological reports were reviewed to delineate the main cytopathologic features, prominent cytological characteristics, the presence of predisposing pathology, and disease stage. Results: Of the 142 cases with CRC, 15.5% and 33.1% were affected before 40 and 50 years of age respectively. Emergency rooms were main referral sites for CRC cases (31.0%). Right colon was affected in 16.9% while left colonic lesions accounted for 62.7%. Intestinal obstruction was the main presentations (41.5%), and 26.1% presented with symptoms indicating distant metastastic lesions. Adenocarcinoma was the predominant pathological lesions (86.6%). Metastastic CRC was diagnosed in 62.7%. Duke's staging showed that 22.5% and 40.1% of lesions were classified into C and D categories respectively. Conclusion: Saudi patients with CRC present late with distant metastasis, and advanced disease stage. A sizeable proportion of patients developed the lesions at relatively young age. Screening recommendations should be enacted and revised in response to current change with younger age of affection.

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Section: Discussionsupporting

confidence: 82%

“…An increased number of young patients with advanced CRC are reported in various studies across the world. Changes in type of CRC and subsite distribution are other global phenomena (Ponz de Leon et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Patients' Profile, Clinical Presentations and Histopathological Features of Colo-rectal Cancer in Al Hassa Region, Saudi Arabia

Amin¹,

Suleman²,

Taissan³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…4 The results obtained in the present cohort provide support for the hypothesis that the incidence rate of colorectal cancer among subjects at long term following BPD is not substantially different from that observed in the general population.…”

supporting

confidence: 80%

Colorectal cancer after biliopancreatic diversion for obesity

2007

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“…No nosso estudo , a população avaliada tinha entre 61 a 80 anos, sendo a idade média 61,8 anos, semelhante ao encontrado na literatura 22,23 , mostrando prevalência da doença em pessoas acima de 50 anos. O adenocarcinoma foi significativamente mais freqüen-te no cólon descendente (95 % dos casos), semelhante ao relatado anteriormente 22 .…”

Section: Discussionunclassified

Expressão das proteínas p53 e Cox-2 em adenocarcinoma intestinal e mucosa adjacente

Felin

Rocha

Felin

et al. 2008

Rev bras. colo-proctol.

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INTRODUÇÃOO carcinoma de intestino é um dos tumores malignos mais comuns no ocidente, correspondendo a terceira causa de morte por câncer 1 . Mais de 80% desses tumores são esporádicos, sendo que os fatores ambientais e dietéticos parecem ser variáveis de grande valor no desenvolvimento desta neoplasia. A histó-ria familiar para o câncer intestinal é observada em até 25% dos casos, e algumas situações como presença de adenomas, constituem risco de desenvolver adenocarcinoma intestinal 2,3,4 .O diagnóstico do câncer colorretal pode ser suspeitado pela história clínica de enterorragia ou sangue oculto nas fezes, dor abdominal, emagrecimento, e confirmado pela endoscopia baixa seguida de biópsia e anatomopatológico 1 . Existem fatores prognósticos para o câncer colônico que estão diretamente relacionados ao sistema pTNM de estadiamento 5 . São estes: infiltração do tumor na gordura pericólica, graduação histológica, obstrução, perfuração, aderência do tumor a órgãos e estruturas adjacentes, invasão angiolinfática e classificação de Dukes e Astler-Coller 3,4,6 . O prognóstico em casos de doença avançada é ruim, e mais

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Trend of incidence, subsite distribution and staging of colorectal neoplasms in the 15-year experience of a specialised cancer registry

Abstract: Our study indicates an increase of tumour incidence in all colonic segments more than a shift to the right colon. TNM staging tended to improve with an appreciable increase of localised lesions. These findings could be consequent to a more extensive use of colonoscopy.

Cited by 55 publications

References 31 publications

Patients' Profile, Clinical Presentations and Histopathological Features of Colo-rectal Cancer in Al Hassa Region, Saudi Arabia

Patients' Profile, Clinical Presentations and Histopathological Features of Colo-rectal Cancer in Al Hassa Region, Saudi Arabia

Colorectal cancer after biliopancreatic diversion for obesity

Expressão das proteínas p53 e Cox-2 em adenocarcinoma intestinal e mucosa adjacente

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