Tremor reduction and quality of life after deep brain stimulation for multiple sclerosis–associated tremor

Zakaria, Rasheed; Vajramani, Giresh; Westmoreland, Leanne; Fletcher, Nick; Eldridge, Paul; Alusi, Sundus; Osman-Farah, Jibril

doi:10.1007/s00701-013-1848-0

Cited by 16 publications

(10 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The short-lived nature of the response is seen in other studies of surgical treatments of MS tremor (67). Improvement in quality of life measures following thalamic stimulation, including improvement in ability to feed oneself, has been demonstrated in selected cases (68). …”

Section: Treatments For Cerebellar Disease In Msmentioning

confidence: 99%

Cerebellar Dysfunction in Multiple Sclerosis

Wilkins

2017

Front. Neurol.

View full text Add to dashboard Cite

Multiple sclerosis (MS) commonly affects the cerebellum causing acute and chronic symptoms. Cerebellar signs contribute significantly to clinical disability, and symptoms such as tremor, ataxia, and dysarthria are particularly difficult to treat. Increasing knowledge concerning the pathophysiology of cerebellar disease in MS from human postmortem studies, experimental models, and clinical trials has raised the hope that cerebellar symptoms will be better treated in the future.

show abstract

Section: Treatments For Cerebellar Disease In Msmentioning

confidence: 99%

Cerebellar Dysfunction in Multiple Sclerosis

Wilkins

2017

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…After removing duplicates, the initial search yielded 623 articles. After applying the inclusion criteria, a final capture of 81 articles 8,9,12,[73][74][75][76][77][78][79][80][81][82][83][84][85][86][87][88][89][90][91][92] was used for data extraction (Figure 1).…”

Section: Search Resultsmentioning

confidence: 99%

Upper Limb Intention Tremor in Multiple Sclerosis

McCreary¹,

Rogers²,

Forwell³

2018

International Journal of MS Care

View full text Add to dashboard Cite

Background: To present the current knowledge on the characteristics, assessment, and treatment of upper limb intention tremor to inform and improve future intervention studies in patients with multiple sclerosis (MS), we conducted a literature review for articles on upper limb intention tremor in patients with MS. Methods: Two reviewers conducted searches in PubMed, Web of Science, and MEDLINE (Ovid). Relevant articles, sorted on inclusion criteria, were examined for descriptions and assessments of upper limb intention tremor, and intervention studies were evaluated based on treatment type. Results: Eight descriptive studies were found reporting on the incidence and severity of tremor, impairments, and lesion load. Ten studies focused on measurement of tremor using various assessments. Intervention studies included eight articles using a diverse set of noninvasive techniques mainly showing transient reduction in tremor amplitude and temporary increase in function. Eighteen studies on pharmacologic interventions were found, with most displaying positive outcomes and mediation of tremor; others showed little to no benefit. Surgical interventions included 17 studies on thalamotomy and 20 on deep brain stimulation. Most studies showed tremor improvement after surgery; however, most sample sizes were small, and interventions were highly invasive, with potential adverse effects resulting from surgery. Conclusions: The literature on upper limb intention tremor in MS is relatively sparse. More studies are required to determine mechanism of action and to provide more suitable and sustainable interventions to decrease upper limb intention tremor and improve quality of life of individuals with MS.

show abstract

“…Ninety‐eight papers were initially identified in the database searches and an additional 10 found by searching bibliographies and with expert consultation. After removing papers that were unrelated to the study question, duplicate results, papers without comparisons for outcomes, and multiple papers based on the same patient cohort, the final number of studies included in the meta‐analysis was 13. The total number of patients included across all manuscripts was 261, 129 received DBS, and 132 received medical management.…”

Section: Resultsmentioning

confidence: 99%

Deep Brain Stimulation for Multiple Sclerosis Tremor: A Meta-Analysis

Brandmeir

Murray

Cheyuo

et al. 2020

Neuromodulation: Technology at the Neural Interface

View full text Add to dashboard Cite

Objectives To examine the effect of deep brain stimulation (DBS) on multiple sclerosis (MS)‐tremor, as measured by a normalized scale of tremor severity, with a meta‐analysis of the published literature. Methods Medline and EBSCO Host (January, 1998 to June, 2018) were systematically reviewed with librarian guidance, using the keywords “Deep brain stimulation” and “multiple sclerosis.” Bibliographies and experts in the field were also consulted to identify missed articles. All therapeutic studies on DBS for MS‐tremor, reported in the English language, within the study period were included. Papers that reported outcomes without a measure of central tendency and/or distribution were excluded. The papers were read in their entirety and graded for risk of bias according to the American Academy of Neurology (AAN) standards. To maximize statistical power, papers using different stimulation targets were grouped together. Outcomes were reported with the Fahn‐Tolosa‐Marin scale (FTM), the Bain‐Finchley scale (CRS) and 3‐ and 4‐point tremor severity scales and normalized with a Hedges g. Results The search produced 13 studies suitable for meta‐analysis. The random‐effects meta‐analysis showed that DBS improved the Hedges standardized mean tremor score by 2.86 (95%CI 2.03–3.70, p < .00001). Heterogeneity was high, with an I2 of 84%, suggesting that random effects model is more appropriate. Adverse event rates varied from 8% to 50%. Conclusions This meta‐analysis provides level III evidence that DBS may improve MS‐related tremor as measured by standardized tremor severity scales.

show abstract

Tremor reduction and quality of life after deep brain stimulation for multiple sclerosis–associated tremor

Cited by 16 publications

References 34 publications

Cerebellar Dysfunction in Multiple Sclerosis

Cerebellar Dysfunction in Multiple Sclerosis

Upper Limb Intention Tremor in Multiple Sclerosis

Deep Brain Stimulation for Multiple Sclerosis Tremor: A Meta-Analysis

Contact Info

Product

Resources

About