Tremella fuciformis enhances the neurite outgrowth of PC12 cells and restores trimethyltin-induced impairment of memory in rats via activation of CREB transcription and cholinergic systems

Fermented Saccharina japonica (Phaeophyta) improves neuritogenic activity and TMT-induced cognitive deficits in rats

“…Genetic and pharmacological studies have provided strong evidence that the CREB signaling pathway is necessary for learning and memory across species (Kogan et al 1997, Jackson andRamaswami 2003). The present study proved that the levels of CREB in the hippocampus were significantly different among the groups (Park et al 2012a(Park et al , 2012b. The present study demonstrated that the TMT treated group showed a reduction of approximately 40% of the CREB activity.…”

“…Exposure of the human population to many chemicals has generated concern about the potential neurotoxicity of new and exciting chemicals (Kaur et al 2013). Our previous studies already proved through experimental observations that TMT-induced neurodegenerative processes support the efficiency and sensitivity of this model for providing insights into the mechanisms of neuro-degeneration (Park et al 2011(Park et al , 2012b. TMT-induced neuronal damage particularly in the hippocampal formation resulted in behavioral alterations such as hyperactivity, impairment of learning and memory (Koczyk 1996, Guo et al 2004, epilepsy and spontaneous seizures (Geloso et al 2011).…”

“…central cholinergic systems or neurotrophic factors such as brain derived neurotrophic factor (BDNF) and cAMP response element binding protein (CREB) (Park et al 2012b).…”

Comparison of structural, antioxidant and immuno‐stimulating activities of polysaccharides from Tremella fuciformis in two different regions of China

“…The chemical structure of TPS backbone chain was mainly composed of a-(1?3) linked D-mannose with b-D-xylose and b-D-glucuronic acid in the side chains (Cho et al, 2006). In the past decades, TPS had received increasing attention due to its diverse pharmacological activities including enhancing humoral immunity, anti-tumour, antioxidant and anti-aging, and hypolipidaemic activities (Park et al, 2012;Wang et al, 2015). Additionally, other literature further indicated that TPS also had excellent moisture-preserving activity (Wang et al, 2015) and skin protection function (Wen et al, 2016), and might be useful for improving the cognitive function (Park et al, 2012).…”

An Integrative Approach to Enhancing Cognition and Executive Brain Function: A Personal Perspective

“…That is why medicinal mushrooms such as Cordyceps militaris (cordyceps), Ganoderma lucidum (reishi), and Tremella fuciformis (tremella) help accomplish this, as they benefit mitochondrial function. [8][9][10] These medicinal mushrooms also are high in natural phospholipids, which protect brain cell membranes. The leading mushroom is cordyceps, followed by reishi and tremella.…”