Trematosphones A and B, Two Unique Dimeric Structures from the Desert Plant Endophytic Fungus Trematosphaeria terricola

Abstract

Trematosphones A (1) and B (2), two unique dimers with novel structural features, were isolated from the special bioenvironmental desert plant endophytic fungus Trematosphaeria terricola. Their structures were assigned on the basis of spectroscopic approaches including NMR, calculated electronic circular dichroism data, and X-ray diffraction analysis. Possible biosynthetic pathways of these two compounds were proposed. Trematosphone A (1) exhibited protective activities against the corticosterone-induced damages in PC12.

Chaetomadrasins A and B, Two New Cytotoxic Cytochalasans from Desert Soil-Derived Fungus Chaetomium madrasense 375

“…In our continued discovery of bioactive natural products from the members of special fungi isolated from the desert and grasslands inhabiting the Northwest of China [16,17,18,19], two new cytochalasan derivatives, Chaetomadrasins A ( 1 ) and B ( 2 ), together with six related known compounds ( 3 – 8 ) (Figure 1), were isolated and identified from the ethyl acetate extract of a solid-state fermented culture of Chaetomium madrasense 375, which was collected from desert soil in Hotan city, Sinkiang province, People’s Republic of China. However, as far as we know, this is the first report on secondary metabolites from the fungi.…”

Structurally Uncommon Secondary Metabolites Derived from Endophytic Fungi

“…Compound 173 featured a 6/7/6/5-fused tetracyclic system with seven stereocenters and eight oxygen atoms forming groups such as carbonyl, ether, hydroxy, and methoxy, and it showed protective activity against corticosterone-induced damage in PC12 cells. Compound 174 possessed a highly axial symmetrical tricyclic structure with nine oxygen atoms and displayed no activity in the same assay [ 98 ]. Cytorhizins A–D ( 175 – 178 ) were obtained from Cytospora rhizophorae , and their structures represent a novel family of functionalized benzophenol derivatives with a cage-like scaffold that comprised a transannular benzophenol core and a highly oxygenated hemiterpene unit, and 6/6/5/6/7 or 6/6/5/6/8 fused ring systems.…”

Marine Natural Products: The Important Resource of Biological Insecticide

“…With the expansion and deepening of relevant research, most of the biological resources are covered to seek nature substances with versatile bioactivities. Special bioenvironmental including deep sea, arctic zones, and symbiotic environments can provide with vital sources for the discovery of secondary metabolites with novel structural features and diverse biological effects to drugs and agricultural chemicals [11–13] . Ocean is the most vast and biologically diverse environment on earth, exploitation of marine resources provides abundant material and energy for mankind [14–16] .…”